Characterization of Hepatitis B virus (HBV) genotypes in patients from Rondônia, Brazil (2010)
- Authors:
- Autor USP: CARRILHO, FLAIR JOSÉ - FM
- Unidade: FM
- DOI: 10.1186/1743-422x-7-315
- Subjects: HEPATITE B (VIROLOGIA); GENÓTIPOS; REAÇÃO EM CADEIA POR POLIMERASE; RONDÔNIA
- Language: Inglês
- Abstract: Background: Hepatitis B virus (HBV) can be classified into nine genotypes (A-I) defined by sequence divergence of more than 8% based on the complete genome. This study aims to identify the genotypic distribution of HBV in 40 HBsAg-positive patients from Rondônia, Brazil. A fragment of 1306 bp partially comprising surface and polymerase overlapping genes was amplified by PCR. Amplified DNA was purified and sequenced. Amplified DNA was purified and sequenced on an ABI PRISM® 377 Automatic Sequencer (Applied Biosystems, Foster City, CA, USA). The obtained sequences were aligned with reference sequences obtained from the GenBank using Clustal X software and then edited with Se-Al software. Phylogenetic analyses were conducted by the Markov Chain Monte Carlo (MCMC) approach using BEAST v.1.5.3. Results: The subgenotypes distribution was A1 (37.1%), D3 (22.8%), F2a (20.0%), D4 (17.1%) and D2 (2.8%). Conclusions: These results for the first HBV genotypic characterization in Rondônia state are consistent with other studies in Brazil, showing the presence of several HBV genotypes that reflects the mixed origin of the population, involving descendants from Native Americans, Europeans, and Africans
- Imprenta:
- Source:
- Título do periódico: Virology Journal
- ISSN: 1743-422X
- Volume/Número/Paginação/Ano: v. 7, n. 315, (on-line), 2010
- Este periódico é de acesso aberto
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: gold
- Licença: cc-by
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ABNT
SANTOS, Alcione Oliveira et al. Characterization of Hepatitis B virus (HBV) genotypes in patients from Rondônia, Brazil. Virology Journal, v. 7, n. 315, 2010Tradução . . Disponível em: https://doi.org/10.1186/1743-422x-7-315. Acesso em: 19 abr. 2024. -
APA
Santos, A. O., Alvarado-Mora, M. V., Botelho, L., Vieira, D. S., Pinho, J. R. R., Carrilho, F. J., et al. (2010). Characterization of Hepatitis B virus (HBV) genotypes in patients from Rondônia, Brazil. Virology Journal, 7( 315). doi:10.1186/1743-422x-7-315 -
NLM
Santos AO, Alvarado-Mora MV, Botelho L, Vieira DS, Pinho JRR, Carrilho FJ, Honda ER, Salcedo JM. Characterization of Hepatitis B virus (HBV) genotypes in patients from Rondônia, Brazil [Internet]. Virology Journal. 2010 ; 7( 315):[citado 2024 abr. 19 ] Available from: https://doi.org/10.1186/1743-422x-7-315 -
Vancouver
Santos AO, Alvarado-Mora MV, Botelho L, Vieira DS, Pinho JRR, Carrilho FJ, Honda ER, Salcedo JM. Characterization of Hepatitis B virus (HBV) genotypes in patients from Rondônia, Brazil [Internet]. Virology Journal. 2010 ; 7( 315):[citado 2024 abr. 19 ] Available from: https://doi.org/10.1186/1743-422x-7-315 - Ultra-sonografia na doença hepática gordurosa não alcoólica (DHGNA)em pacientes portadores de obesidade mórbida
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Informações sobre o DOI: 10.1186/1743-422x-7-315 (Fonte: oaDOI API)
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