Dipeptidyl peptidase IV inhibition delays onset of hypertension in spontaneously hypertensive rats. (2010)
- USP affiliated authors: ROSSONI, LUCIANA VENTURINI - ICB
- Unidades: ICB
- Subjects: FISIOLOGIA
- Language: Inglês
- Abstract: OBJETIVOS: Renal sodium homeostasis is one of the major determinants for blood pressure levels. We have previously found that dipeptidyl peptidase IV (DPPIV) inhibitors reduce proximal tubule (PT) NHE3-mediated sodium reabsorption and cause a trend towards reduction of blood pressure in normotensive rats. The present study aimed to assess the effect of the specific DPPIV inhibitor sitagliptin on blood pressure and renal function in young pre-hypertensive (5-week-old) and adult spontaneously hypertensive rats (SHR) (14-week-old). MÉTODO E RESULTADOS: Sitagliptin (40 mg/kg/day) was given by oral gavage to young (Y-SHR + IDPPIV) and adult (A-SHR + IDPPIV) SHR for eight days. Kidney function was assessed daily and compared with age-matched vehicle-treated SHR (Y-SHR and A-SHR)and with normotensive Wistar Kyoto rats (Y-WKY and A-WKY). Arterial blood pressure was measured in these animals at the end of the experimental protocol. Additionally, NHE3 function and expression in microvilli membrane vesicles(MMV)were assessed in young animals.Mean arterial blood pressure of Y-SHR + IDPPIV was significantly lower than Y-SHR (104 ± 3 vs. 123 ± 5 mmHg, P<0.01), and was similar to Y-WKY (94 ± 4 mmHg, P>0.05). Compared to Y-SHR, Y-SHR + IDPPIV exhibited enhanced cumulative urinary flow and sodium excretion and decreased NHE3 activity and expression in PT MMV. In the A-SHR, sitagliptin treatment had no significant effect on either renal function or arterial blood pressure. CONCLUSÃO: Our data suggest that DPPIV inhibition attenuates blood pressure rising in young pre-hypertensive SHR partially by inhibiting PT NHE3 activity.
- Título do periódico: Resumos
- Conference title: Reunião Anual da Federação de Sociedades de Biologia Experimental
ABNTPACHECO, B. P.; CRAJOINAS, R. O.; COUTO, G. K.; et al. Dipeptidyl peptidase IV inhibition delays onset of hypertension in spontaneously hypertensive rats. Anais.. São Paulo: FeSBE, 2010.
APAPacheco, B. P., Crajoinas, R. O., Couto, G. K., Davel, A. P., Lessa, L. M., Rossoni, L. V., & Girardi, A. C. C. (2010). Dipeptidyl peptidase IV inhibition delays onset of hypertension in spontaneously hypertensive rats. In Resumos. São Paulo: FeSBE.
NLMPacheco BP, Crajoinas RO, Couto GK, Davel AP, Lessa LM, Rossoni LV, Girardi ACC. Dipeptidyl peptidase IV inhibition delays onset of hypertension in spontaneously hypertensive rats. Resumos. 2010 ;
VancouverPacheco BP, Crajoinas RO, Couto GK, Davel AP, Lessa LM, Rossoni LV, Girardi ACC. Dipeptidyl peptidase IV inhibition delays onset of hypertension in spontaneously hypertensive rats. Resumos. 2010 ;
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