Dipeptidyl peptidase IV inhibition delays onset of hypertension in spontaneously hypertensive rats. (2010)
- Authors:
- Autor USP: ROSSONI, LUCIANA VENTURINI - ICB
- Unidade: ICB
- Assunto: FISIOLOGIA
- Language: Inglês
- Abstract: OBJETIVOS: Renal sodium homeostasis is one of the major determinants for blood pressure levels. We have previously found that dipeptidyl peptidase IV (DPPIV) inhibitors reduce proximal tubule (PT) NHE3-mediated sodium reabsorption and cause a trend towards reduction of blood pressure in normotensive rats. The present study aimed to assess the effect of the specific DPPIV inhibitor sitagliptin on blood pressure and renal function in young pre-hypertensive (5-week-old) and adult spontaneously hypertensive rats (SHR) (14-week-old). MÉTODO E RESULTADOS: Sitagliptin (40 mg/kg/day) was given by oral gavage to young (Y-SHR + IDPPIV) and adult (A-SHR + IDPPIV) SHR for eight days. Kidney function was assessed daily and compared with age-matched vehicle-treated SHR (Y-SHR and A-SHR)and with normotensive Wistar Kyoto rats (Y-WKY and A-WKY). Arterial blood pressure was measured in these animals at the end of the experimental protocol. Additionally, NHE3 function and expression in microvilli membrane vesicles(MMV)were assessed in young animals.Mean arterial blood pressure of Y-SHR + IDPPIV was significantly lower than Y-SHR (104 ± 3 vs. 123 ± 5 mmHg, P<0.01), and was similar to Y-WKY (94 ± 4 mmHg, P>0.05). Compared to Y-SHR, Y-SHR + IDPPIV exhibited enhanced cumulative urinary flow and sodium excretion and decreased NHE3 activity and expression in PT MMV. In the A-SHR, sitagliptin treatment had no significant effect on either renal function or arterial blood pressure. CONCLUSÃO: Our data suggest that DPPIV inhibition attenuates blood pressure rising in young pre-hypertensive SHR partially by inhibiting PT NHE3 activity.
- Imprenta:
- Source:
- Título: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental
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ABNT
PACHECO, B. P. et al. Dipeptidyl peptidase IV inhibition delays onset of hypertension in spontaneously hypertensive rats. 2010, Anais.. São Paulo: FeSBE, 2010. . Acesso em: 12 fev. 2026. -
APA
Pacheco, B. P., Crajoinas, R. O., Couto, G. K., Davel, A. P., Lessa, L. M., Rossoni, L. V., & Girardi, A. C. C. (2010). Dipeptidyl peptidase IV inhibition delays onset of hypertension in spontaneously hypertensive rats. In Resumos. São Paulo: FeSBE. -
NLM
Pacheco BP, Crajoinas RO, Couto GK, Davel AP, Lessa LM, Rossoni LV, Girardi ACC. Dipeptidyl peptidase IV inhibition delays onset of hypertension in spontaneously hypertensive rats. Resumos. 2010 ;[citado 2026 fev. 12 ] -
Vancouver
Pacheco BP, Crajoinas RO, Couto GK, Davel AP, Lessa LM, Rossoni LV, Girardi ACC. Dipeptidyl peptidase IV inhibition delays onset of hypertension in spontaneously hypertensive rats. Resumos. 2010 ;[citado 2026 fev. 12 ] - Long-term ouabain treatment impairs vascular function in resistance arteries
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