Color vision impairment is associated with cognitive deficits in Duchenne Muscular Dystrophy patients (2010)
- Authors:
- USP affiliated authors: COSTA, MARCELO FERNANDES DA - IP ; VENTURA, DORA SELMA FIX - IP
- Unidade: IP
- Subjects: PERCEPÇÃO DE COR; PERCEPÇÃO VISUAL; CÓRTEX VISUAL
- Language: Inglês
- Abstract: Methods:20 DMD patients with age ranging from 11 to 26 years were tested. Color vision was evaluated using the Cambridge Color Test (CCT) using the Trivector protocol to measure discrimination thresholds in the protan, deutan and tritan color confusion axis (0.1977, 0.4689 u\2019v\2019 coordinates of the CIE 1976 color space). Cognitive performance was assessed using tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB), including working memory examination (Spatial Span, SSP), spatial short term memory (Spatial Recognition Memory, SRM), short and long term visual memory (Pattern Recognition Memory, PRM), and perception and memory for complex stimuli presented simultaneously or after short interval (Delayed Matching to Sample, DMS). The participants had intellectual scores in the normal range according to the Wechsler Intelligence Scale or the Raven Matrices Test. Results:11 out of 20 patients had losses in the protan axis. These patients performed significantly worse on DMS scores in trials in which the sample and the choice patterns were shown simultaneously. Patients with protan losses, which in addition, had deutan losses (n=7) showed the same result and significantly lower scores on PRM delayed recall (main effects ANOVA, p<0.05). Conclusions:visual perception was impaired in DMD patients with protan or deutan defects. Long term visual memory deficit was associated with combined (protan/deutan) defects. Color vision impairment in DMD may reflect selective parvocellular dysfunction since it is restricted to the red-green axis. In agreement with this, the visual memory losses detected were for detailed shapes with chromatic information, which are processed in ventral stream sites and receive parvocellular input, but not for stimuli which activate mainly the magnocellular pathway (SSP and SRM).There seems to be, therefore, an association between impairment in visual perception/visual memory performance and damage in parvocellular pathways, but not in magno pathways. Further analysis should clarify if these associations are found in non DMD individuals
- Imprenta:
- Publisher: Association for Research in Vision and Ophthalmology
- Publisher place: Lauderdale, Florida
- Date published: 2010
- Source:
- Título: Anais
- Conference titles: Annual Meeting of the Association for Research in Vision and Ophthalmology
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ABNT
ZACHI, E. C et al. Color vision impairment is associated with cognitive deficits in Duchenne Muscular Dystrophy patients. 2010, Anais.. Lauderdale, Florida: Association for Research in Vision and Ophthalmology, 2010. Disponível em: http://abstracts.iovs.org/cgi/content/abstract/51/5/6302?maxtoshow=&hits=10&RESULTFORMAT=&author1=Costa%2C+MF&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT. Acesso em: 25 jan. 2026. -
APA
Zachi, E. C., Costa, M. F. da, Taub, A., & Ventura, D. S. F. (2010). Color vision impairment is associated with cognitive deficits in Duchenne Muscular Dystrophy patients. In Anais. Lauderdale, Florida: Association for Research in Vision and Ophthalmology. Recuperado de http://abstracts.iovs.org/cgi/content/abstract/51/5/6302?maxtoshow=&hits=10&RESULTFORMAT=&author1=Costa%2C+MF&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT -
NLM
Zachi EC, Costa MF da, Taub A, Ventura DSF. Color vision impairment is associated with cognitive deficits in Duchenne Muscular Dystrophy patients [Internet]. Anais. 2010 ;[citado 2026 jan. 25 ] Available from: http://abstracts.iovs.org/cgi/content/abstract/51/5/6302?maxtoshow=&hits=10&RESULTFORMAT=&author1=Costa%2C+MF&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT -
Vancouver
Zachi EC, Costa MF da, Taub A, Ventura DSF. Color vision impairment is associated with cognitive deficits in Duchenne Muscular Dystrophy patients [Internet]. Anais. 2010 ;[citado 2026 jan. 25 ] Available from: http://abstracts.iovs.org/cgi/content/abstract/51/5/6302?maxtoshow=&hits=10&RESULTFORMAT=&author1=Costa%2C+MF&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT - Genetic analysis of color vision defects in Duchenne Muscular Dystrophy and leber's hereditary optic neuropathy
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