Contrast sensitivity to achromatic spatial drifting gratings in asymptomatic carriers of the MtDNA 11778 mutation Leber's Hereditary Optic Neuropathy (LHON) (2010)
- Authors:
- USP affiliated authors: COSTA, MARCELO FERNANDES DA - IP ; VENTURA, DORA SELMA FIX - IP
- Unidade: IP
- Subjects: DEFICIÊNCIA VISUAL; RETINA; NEUROFTALMOLOGIA
- Language: Inglês
- Abstract: Purpose:To determine contrast sensitivities in LHON carriers for drifting gratings of spatial frequencies and velocities presented in parameter combinations designed to activate selectively either the magno- or the parvocellular pathways. Methods:Thirty LHON carriers (20 women) and 32 age-matched controls (17 women), with best-corrected 20/20 Snellen VA or better were tested monocularly in a darkened room. Contrast sensitivity to drifting spatial frequency gratings of functions was measured with the computerized software PSYCHO for Windows v 2.36 (CRS Ltd., Cambridge, England), with a VSG 2/4 graphic board and a Sony FD Trinitron monitor. Gratings of .5 and 9 cpd were drifted upward at temporal frequencies of .5, 7.5, and 15c/sec. Factorial ANOVA was run considering group and gender effects. Results:Average contrast sensitivity in carriers was uniformly lower for all conditions, compared to controls for .5 cpd (1.5 c/sec, p=.004; 7.5 c/sec, p= .033; 15c/sec, p<.001) and 10 cpd (1.5 c/sec, p<.001; 7.5 c/sec, p=.001; 15c/sec, p<.001). Gender difference was significant for 0.5 cpd (7.5 c/sec, p=.037; 15c/sec, p<.042). Comparing the proportion of LHON carriers with lower values than control’s percentile 5% for contrast sensitivity a statistical higher number of carriers with results below this value was measured for 7.5 (p= .004) and 15 c/sec (p= .001). Conclusions:Recent evidence from several studies has shown that clinically asymptomatic LHON carriers present losses in several visual functions. In the present study, losses in contrast sensitivity to a drifting grating were found. The magnocellular activating stimulus (grating with high temporal frequency and low spatial frequency) was associated with losses with short magnitude from those found for the parvocellular activating stimulus (grating with low temporal frequency and high spatial frequency. These results are complementary to those previously reported for stationary conditions showing amagnocellular impairment in addition to a stronger parvocellular damage
- Imprenta:
- Publisher: Association for Research in Vision and Ophthalmology
- Publisher place: Lauderdale, Florida
- Date published: 2010
- Source:
- Título: Anais
- Conference titles: Annual Meeting of the Association for Research in Vision and Ophthalmology
-
ABNT
COSTA, Marcelo Fernandes da et al. Contrast sensitivity to achromatic spatial drifting gratings in asymptomatic carriers of the MtDNA 11778 mutation Leber's Hereditary Optic Neuropathy (LHON). 2010, Anais.. Lauderdale, Florida: Association for Research in Vision and Ophthalmology, 2010. Disponível em: http://abstracts.iovs.org/cgi/content/abstract/51/5/997?maxtoshow=&hits=10&RESULTFORMAT=1&author1=Costa%2C+MF&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&fdate=2/1/2010&resourcetype=HWCIT,HWELTR. Acesso em: 28 dez. 2025. -
APA
Costa, M. F. da, Gualtieri, M., Oliveira, A. G. F., Moreira, S. M. C. F., Sadun, F., Berezovsky, A., et al. (2010). Contrast sensitivity to achromatic spatial drifting gratings in asymptomatic carriers of the MtDNA 11778 mutation Leber's Hereditary Optic Neuropathy (LHON). In Anais. Lauderdale, Florida: Association for Research in Vision and Ophthalmology. Recuperado de http://abstracts.iovs.org/cgi/content/abstract/51/5/997?maxtoshow=&hits=10&RESULTFORMAT=1&author1=Costa%2C+MF&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&fdate=2/1/2010&resourcetype=HWCIT,HWELTR -
NLM
Costa MF da, Gualtieri M, Oliveira AGF, Moreira SMCF, Sadun F, Berezovsky A, Salomão SR, Carelli V, Sadun A, Ventura DSF. Contrast sensitivity to achromatic spatial drifting gratings in asymptomatic carriers of the MtDNA 11778 mutation Leber's Hereditary Optic Neuropathy (LHON) [Internet]. Anais. 2010 ;[citado 2025 dez. 28 ] Available from: http://abstracts.iovs.org/cgi/content/abstract/51/5/997?maxtoshow=&hits=10&RESULTFORMAT=1&author1=Costa%2C+MF&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&fdate=2/1/2010&resourcetype=HWCIT,HWELTR -
Vancouver
Costa MF da, Gualtieri M, Oliveira AGF, Moreira SMCF, Sadun F, Berezovsky A, Salomão SR, Carelli V, Sadun A, Ventura DSF. Contrast sensitivity to achromatic spatial drifting gratings in asymptomatic carriers of the MtDNA 11778 mutation Leber's Hereditary Optic Neuropathy (LHON) [Internet]. Anais. 2010 ;[citado 2025 dez. 28 ] Available from: http://abstracts.iovs.org/cgi/content/abstract/51/5/997?maxtoshow=&hits=10&RESULTFORMAT=1&author1=Costa%2C+MF&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&fdate=2/1/2010&resourcetype=HWCIT,HWELTR - Maturation of Binocular, Monocular Grating Acuity and of the Visual Interocular Difference in the First 2 Years of Life
- Absence of binocular summation, eye dominance, and learning effects in color discrimination
- Evaluation of Effect of Fetal Growth Restriction (FGR) on visual acuity development in fulterm brazilian newborns: prelimanary results using Preferential-Looking (PL) and Sweep Vep (sVEP)
- The parallel visual pathways P30 in Parkinson\2019s disease
- Color vision impairment in type 2 diabetes assessed by the D-15d test and the Cambridge Colour Test Claudia Feitosa-Santana
- Visual losses in early-onset and late-onset Parkinson’s disease
- Irreversible color vision losses in patients with chronic mercury vapor intoxication
- Estudo Visão de cores em bebês
- Early infancy development of discrimination in protan, deutan and tritan color confusion axes using 2-AFC version of the Cambridge Colour Test
- Chromatic discrimination losses in multiple sclerosis patients with and without optic neuritis using the Cambridge Colour Test
Download do texto completo
| Tipo | Nome | Link | |
|---|---|---|---|
 |
CMar-036.pdf |
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
