Relationship between ethanol and sucrose self-administration and schedule-induced polydipsia (2008)
- Authors:
- Autor USP: SILVA, MARIA TERESA DE ARAUJO - IP
- Unidade: IP
- DOI: 10.1016/j.pbb.2008.04.019
- Subjects: DROGAS DE ABUSO; DISTÚRBIOS DO COMPORTAMENTO; VÍCIO
- Language: Inglês
- Abstract: Studies have suggested a relationship between drug abuse and compulsive behaviors. The present experiments investigated the relationship between schedule-induced polydipsia (SIP) and self-administration (SA) of ethanol and sucrose. SIP served as a model of compulsive behavior, and oral self-administration on a progressive-ratio (PR) schedule of reinforcement assessed the reinforcing value of either a 10% ethanol solution or an isocaloric sucrose solution. Rats first were exposed to PR sessions in which break points were the dependent variable and then switched to SIP sessions, with number of licks as the dependent variable. Results showed a positive relationship between PR and SIP for sucrose but not for ethanol: higher and lower PRs for sucrose were associated with higher and lower SIP levels. The order of the sessions then was reversed, such that SIP sessions were run before PR sessions. An opposite relationship was observed in which high and low SIP animals exhibited low and high PR break points, respectively. The relationship between SIP and SA was dependent on the reinforcing value of the substance and on prior SIP exposure. These results may reflect a common dopaminergic substrate and suggest that prior experience in coping with stress may reduce vulnerability to substance abuse behavior
- Imprenta:
- Source:
- Título do periódico: Pharmacology, Biochemistry and Behavior
- Volume/Número/Paginação/Ano: v. 90, n. 4, p. 586-589, 2008
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
-
ABNT
TOSCANO, Claudia Tavares et al. Relationship between ethanol and sucrose self-administration and schedule-induced polydipsia. Pharmacology, Biochemistry and Behavior, v. 90, n. 4, p. 586-589, 2008Tradução . . Disponível em: https://doi.org/10.1016/j.pbb.2008.04.019. Acesso em: 24 abr. 2024. -
APA
Toscano, C. T., Kameyama, M., Mijares, M. G., Silva, M. T. A., & Santarém, E. M. M. (2008). Relationship between ethanol and sucrose self-administration and schedule-induced polydipsia. Pharmacology, Biochemistry and Behavior, 90( 4), 586-589. doi:10.1016/j.pbb.2008.04.019 -
NLM
Toscano CT, Kameyama M, Mijares MG, Silva MTA, Santarém EMM. Relationship between ethanol and sucrose self-administration and schedule-induced polydipsia [Internet]. Pharmacology, Biochemistry and Behavior. 2008 ; 90( 4): 586-589.[citado 2024 abr. 24 ] Available from: https://doi.org/10.1016/j.pbb.2008.04.019 -
Vancouver
Toscano CT, Kameyama M, Mijares MG, Silva MTA, Santarém EMM. Relationship between ethanol and sucrose self-administration and schedule-induced polydipsia [Internet]. Pharmacology, Biochemistry and Behavior. 2008 ; 90( 4): 586-589.[citado 2024 abr. 24 ] Available from: https://doi.org/10.1016/j.pbb.2008.04.019 - Estimulação transcraniana por corrente contínua em córtex pré-frontal melhora o funcionamento da memória operacional
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Informações sobre o DOI: 10.1016/j.pbb.2008.04.019 (Fonte: oaDOI API)
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