Artigo de periodico

Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia (2008)

• Authors:
  • Cardoso, Maria Regina Alves
  • Nascimento-Carvalho, Cristiana M
  • Ferrero, Fernando
  • Berezin, Eitan N
  • Ruvinsky, Raul
  • Camargos, Paulo A M
  • Sant'Anna, Clemax Couto
  • Brandileone, Maria Cristina de Cunto
  • March, Maria de Fátima P
  • Feris-Iglesias, Jesus
  • Maggi, Ruben S
  • Benguigui, Yehuda
• Autor USP: CARDOSO, MARIA REGINA ALVES - FSP
• Unidade: FSP
• DOI: 10.1136/adc.2006.111625
• Subjects: STREPTOCOCCUS (RESISTÊNCIA); PNEUMONIA (QUIMIOTERAPIA); RESISTÊNCIA MICROBIANA ÀS DROGAS
• Language: Inglês
• Abstract: Objective: To determine whether the presence of in vitro penicillin-resistant Streptococcus pneumoniae increases the risk of clinical failure in children hospitalised with severe pneumonia and treated with penicillin/ampicillin. Design: Multicentre, prospective, observational study. Setting: 12 tertiary-care centres in three countries in Latin America. Patients: 240 children aged 3-59 months, hospitalised with severe pneumonia and known in vitro susceptibility of S pneumoniae. Intervention: Patients were treated with intravenous penicillin/ampicillin after collection of blood and, when possible, pleural fluid for culture. The minimal inhibitory concentration (MIC) test was used to determine penicillin susceptibility of the pneumococcal strains isolated. Children were continuously monitored until discharge. Main outcome measures: The primary outcome was treatment failure (using clinical criteria). Results: Overall treatment failure was 21%. After allowing for different potential confounders, there was no evidence of association between treatment failure and in vitro resistance of S pneumoniae to penicillin according to the Clinical Laboratory Standards Institute (CLSI)/National Committee for Clinical Laboratory Standards (NCCLS) interpretative standards (adjRR = 1.03; 95%CI: 0.49-1.90 for resistant S pneumoniae). Conclusions: Intravenous penicillin/ampicillin remains the drug of choice for treating penicillin-resistant pneumococcal pneumonia in areas wherethe MIC does not exceed 2 [mu]g/ml
• Imprenta:
  • Publisher place: London
  • Date published: 2008
• Source:
  • Título: Archives of Disease in Childhood
  • ISSN: 0003-9888
  • Volume/Número/Paginação/Ano: v. 93, n. 3, p. 221-225, March 2008

Informações sobre o DOI: 10.1136/adc.2006.111625 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo é de acesso aberto
• URL de acesso aberto
• Cor do Acesso Aberto: green
• Licença: other-oa

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How to cite

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• ABNT

  CARDOSO, Maria Regina Alves et al. Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia. Archives of Disease in Childhood, v. 93, n. 3, p. 221-225, 2008Tradução . . Disponível em: https://doi.org/10.1136/adc.2006.111625. Acesso em: 27 dez. 2025.

• APA

  Cardoso, M. R. A., Nascimento-Carvalho, C. M., Ferrero, F., Berezin, E. N., Ruvinsky, R., Camargos, P. A. M., et al. (2008). Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia. Archives of Disease in Childhood, 93( 3), 221-225. doi:10.1136/adc.2006.111625

• NLM

  Cardoso MRA, Nascimento-Carvalho CM, Ferrero F, Berezin EN, Ruvinsky R, Camargos PAM, Sant'Anna CC, Brandileone MC de C, March M de FP, Feris-Iglesias J, Maggi RS, Benguigui Y. Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia [Internet]. Archives of Disease in Childhood. 2008 ; 93( 3): 221-225.[citado 2025 dez. 27 ] Available from: https://doi.org/10.1136/adc.2006.111625

• Vancouver

  Cardoso MRA, Nascimento-Carvalho CM, Ferrero F, Berezin EN, Ruvinsky R, Camargos PAM, Sant'Anna CC, Brandileone MC de C, March M de FP, Feris-Iglesias J, Maggi RS, Benguigui Y. Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia [Internet]. Archives of Disease in Childhood. 2008 ; 93( 3): 221-225.[citado 2025 dez. 27 ] Available from: https://doi.org/10.1136/adc.2006.111625

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