Artigo de periodico

Low nanomolar concentration of mercury chloride increases vascular reactivity to phenylephrine and local angiotensin production in rats (2008)

• Authors:
  • Wiggers, Giulia Alessandra - Universidade Federal do Espírito Santo (UFES)
  • Stefanon, Ivanita - Universidade Federal do Espírito Santo (UFES)
  • Padilha, Alessandra Simão Padilha - Universidade Federal do Espírito Santo (UFES)
  • Peçanha, Franck Maciel - Universidade Federal do Espírito Santo (UFES)
  • Vassallo, Dalton Valentim - Universidade Federal do Espírito Santo (UFES)
  • Oliveira, E. M.
• Autor USP: OLIVEIRA, EDILAMAR MENEZES DE - EEFE
• Unidade: EEFE
• DOI: 10.1016/j.cbpc.2007.10.003
• Subjects: FISIOLOGIA; MERCÚRIO (ELEMENTO QUÍMICO); ENDOTÉLIO; ÓXIDO NÍTRICO
• Language: Inglês
• Abstract: Exposure to mercury at nanomolar level affects cardiac function but its effects on vascular reactivity have yet to be investigated. Pressor responses to phenylephrine (PHE) were investigated in perfused rat tail arteries before and after treatment with 6 nM Hg´Cl IND. 2´ during 1 h, in the presence (E+) and absence (E?) of endothelium, after L-NAME (´10 POT. -4´) M, indomethacin (´10 POT.-5´) M, enalaprilate (´1 mü´M), tempol (´1 mü´M) and deferoxamine (´300 mü´M) treatments. Hg´Cl IND. 2´ increased sensitivity (p IND. 2´) without modifying the maximum response (Emax) to PHE, but the ´p IND. 2´ increase was abolished after endothelial damage. L-NAME treatment increased ´p IND. 2´ and Emax. However, in the presence of ´ Hg IND. 2´ , this increase was smaller, and it did not modify Emax. After indomethacin treatment, the increase of ´p IND. 2´ induced by Hg´Cl IND. 2´ was maintained. Enalaprilate, tempol and deferoxamine reversed the increase of ´p IND. 2´ evoked by Hg´Cl IND. 2´ . Hg´Cl IND. 2´ increased the angiotensin converting enzyme (ACE) activity explaining the result obtained with enalaprilate. Results suggest that at nanomolar concentrations Hg ´Cl IND. 2´ increase the vascular reactivity to PHE. This response is endothelium mediated and involves the reduction of NO bioavailability and the action of reactive oxygen species. The local ACE participates in mercury actions and depends on the angiotensin II generation
• Imprenta:
  • Publisher place: Oxford
  • Date published: 2008
• Source:
  • Título do periódico: Comparative Biochemistry and Physiology (CBP). Part C: Toxicology and Pharmacology
  • Volume/Número/Paginação/Ano: v. 147, n. 2,p. 252-260, mar. 2008

Informações sobre o DOI: 10.1016/j.cbpc.2007.10.003 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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• ABNT

  WIGGERS, Giulia Alessandra; STEFANON, Ivanita; PADILHA, Alessandra Simão Padilha; et al. Low nanomolar concentration of mercury chloride increases vascular reactivity to phenylephrine and local angiotensin production in rats. Comparative Biochemistry and Physiology (CBP). Part C: Toxicology and Pharmacology, Oxford, v. 147, n. 2, p. 252-260, 2008. Disponível em: < http://www.sciencedirect.com/science/journal/15320456 > DOI: 10.1016/j.cbpc.2007.10.003.

• APA

  Wiggers, G. A., Stefanon, I., Padilha, A. S. P., Peçanha, F. M., Vassallo, D. V., & Oliveira, E. M. (2008). Low nanomolar concentration of mercury chloride increases vascular reactivity to phenylephrine and local angiotensin production in rats. Comparative Biochemistry and Physiology (CBP). Part C: Toxicology and Pharmacology, 147( 2), 252-260. doi:10.1016/j.cbpc.2007.10.003

• NLM

  Wiggers GA, Stefanon I, Padilha ASP, Peçanha FM, Vassallo DV, Oliveira EM. Low nanomolar concentration of mercury chloride increases vascular reactivity to phenylephrine and local angiotensin production in rats [Internet]. Comparative Biochemistry and Physiology (CBP). Part C: Toxicology and Pharmacology. 2008 ; 147( 2): 252-260.Available from: http://www.sciencedirect.com/science/journal/15320456

• Vancouver

  Wiggers GA, Stefanon I, Padilha ASP, Peçanha FM, Vassallo DV, Oliveira EM. Low nanomolar concentration of mercury chloride increases vascular reactivity to phenylephrine and local angiotensin production in rats [Internet]. Comparative Biochemistry and Physiology (CBP). Part C: Toxicology and Pharmacology. 2008 ; 147( 2): 252-260.Available from: http://www.sciencedirect.com/science/journal/15320456

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