Artigo de periodico

Exercise training delays cardiac dysfunction and prevents calcium handling (2008)

• Authors:
  • Medeiros, Alessandra
  • Rolim, Natale P.L.
  • Oliveira, Rodrigo S. F.
  • Rosa, Kaleizu T
  • Mattos, Katt Coelho
  • Casarini, Dulce E.
  • Irigoyen, Maria C.
  • Krieger, Eduardo M.
  • Krieger, José Eduardo
  • Negrão, C. E.
  • Brum, Patrícia Chakur
• USP affiliated authors: MATTOS, KATT COELHO - EEFE ; KRIEGER, EDUARDO MOACYR - FM ; KRIEGER, JOSE EDUARDO - FM ; NEGRÃO, CARLOS EDUARDO - EEFE ; BRUM, PATRICIA CHAKUR - EEFE
• Unidades: EEFE; FM
• Subjects: CARDIOLOGIA; EXERCÍCIO FÍSICO; FISIOLOGIA DO EXERCÍCIO
• Language: Inglês
• Abstract: Exercise training (ET) is a coadjuvant therapy in preventive cardiology. It delays cardiac dysfunction and exercise intolerance in heart failure (HF); however, the molecular mechanisms underlying its cardioprotection are poorly understood. We tested the hypothesis that ET would prevent Ca2+ handling abnormalities and ventricular dysfunction in sympathetic hyperactivity-induced HF mice. A cohort of male wild-type (WT) and congenic ´alfa IND.2A´/´alfa IND.2C´-adrenoceptor knockout (´alfa IND.2A´/´alfa IND.2C´ARKO) mice with C57BL6/J genetic background (3-5 mo of age) were randomly assigned into untrained and exercise-trained groups. ET consisted of 8-wk swimming session, 60 min, 5 days/wk. Fractional shortening (FS) was assessed by two-dimensional guided M-mode echocardiography. The protein expression of ryanodine receptor (RyR), ´phospho-Ser POT.2809´-RyR, sarcoplasmic reticulum ´Ca POT.2+´ ATPase (SERCA2), ´Na POT.+´/´Ca POT.2+´ exchanger (NCX), phospholamban (PLN), 'phospho-Ser POT 16´-PLN, and 'phospho-Thr POT.17´-PLN were analyzed by Western blotting. At 3 mo of age, no significant difference in FS and exercise tolerance was observed between WT and ´alfa IND.2A´/´alfa IND.2C´ARKO mice. At 5 mo, when cardiac dysfunction is associated with lung edema and increased plasma norepinephrine levels, ´alfa IND.2A´/´alfa IND.2C ARKO mice presented reduced FS paralleled by decreased SERCA2 (26%) and NCX (34%). Conversely, ´alfa IND.2A´/´alfaIND.2C´ARKO mice displayed increased phospho-Ser16-PLN (76%) and phospho-Ser POT.2809´-RyR (49%). ET in ´alfa IND.2A´/´alfa IND.2C´ARKO mice prevented exercise intolerance, ventricular dysfunction, and decreased plasma norepinephrine. ET significantly increased the expression of SERCA2 (58%) and ´phospho-Ser POT. 16'-PLN (30%) while it restored the expression of ´phospho-Ser POT.2809´-RyR to WT levels. Collectively, we provide evidence that improved net balance of ´Ca POT.2+´ handling proteins paralleled by a decreased sympathetic activity on ET are, at least in part, compensatory mechanisms against deteriorating ventricular function in HF
• Imprenta:
  • Publisher place: Dordrecht
  • Date published: 2008
• Source:
  • Título: Journal of Applied Physiology
  • Volume/Número/Paginação/Ano: v. 104, 103-109, 2008


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How to cite

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• ABNT

  MEDEIROS, Alessandra et al. Exercise training delays cardiac dysfunction and prevents calcium handling. Journal of Applied Physiology, v. 104, 2008Tradução . . Disponível em: http://jap.physiology.org/cgi/content/abstract/104/1/103. Acesso em: 02 out. 2024.

• APA

  Medeiros, A., Rolim, N. P. L., Oliveira, R. S. F., Rosa, K. T., Mattos, K. C., Casarini, D. E., et al. (2008). Exercise training delays cardiac dysfunction and prevents calcium handling. Journal of Applied Physiology, 104. Recuperado de http://jap.physiology.org/cgi/content/abstract/104/1/103

• NLM

  Medeiros A, Rolim NPL, Oliveira RSF, Rosa KT, Mattos KC, Casarini DE, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Brum PC. Exercise training delays cardiac dysfunction and prevents calcium handling [Internet]. Journal of Applied Physiology. 2008 ; 104[citado 2024 out. 02 ] Available from: http://jap.physiology.org/cgi/content/abstract/104/1/103

• Vancouver

  Medeiros A, Rolim NPL, Oliveira RSF, Rosa KT, Mattos KC, Casarini DE, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Brum PC. Exercise training delays cardiac dysfunction and prevents calcium handling [Internet]. Journal of Applied Physiology. 2008 ; 104[citado 2024 out. 02 ] Available from: http://jap.physiology.org/cgi/content/abstract/104/1/103

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