Quantification of propofol in smallvolumes of plasma using high-performance liquid chromatography with fluorescence detection: therapeutic drug monitoring of one patient (2007)
- Authors:
- USP affiliated authors: CARMONA, MARIA JOSE CARVALHO - FM ; AULER JUNIOR, JOSE OTAVIO COSTA - FM ; SANTOS, SILVIA REGINA CAVANI JORGE - FCF
- Unidades: FM; FCF
- Subjects: CROMATOGRAFIA LÍQUIDA; ELETROQUÍMICA
- Language: Inglês
- Abstract: A liquid chromatographic method with fluorescence detection for determination of propofol in small volumes of plasma has been adapted to the conditions of the laboratory using a C18 column. Peaks were eluted at 21 min propofol and at 12 min thymol (internal standard) using a binary mobile phase at flow rate 0.8 mL/min. The method validated presents 0.05 mg/L sensitivity, 0.1 - 10 mg/L linearity, ('r POT. 2' 0.9977), systematic error of 8.2 and 7.0% (intra- and interday accuracy), intra- and interday precision (CV %: 8.4% and 8.8%). Recovery 93.9%, good stability and robustness were reported. The analytical method was validated by the quantification of propofol in arterial plasma ('C IND. Max':3.3 mg/L 'CIND. Min': 0.2mg/L) of one patient received 1570 mg infusion of propofol in the perioperative period of surgery of myocardial revascularization. Depth of anaesthesia expressed as bispectral index (BIS) was 36 (32-40) in that period up to the '4 IND. Th', and an adequate hypnosis was obtained until the end of surgery
- Imprenta:
- Publisher place: Buenos Aires
- Date published: 2007
- Source:
- Título: Latin American Journal of Pharmacy = Acta Farmacéutica Bonaerense
- ISSN: 0326-2383
- Volume/Número/Paginação/Ano: v.26, n.5, p.748-754, 2007
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ABNT
SILVA FILHO, Carlos Roberto da et al. Quantification of propofol in smallvolumes of plasma using high-performance liquid chromatography with fluorescence detection: therapeutic drug monitoring of one patient. Latin American Journal of Pharmacy = Acta Farmacéutica Bonaerense, v. 26, n. 5, p. 748-754, 2007Tradução . . Acesso em: 05 mar. 2026. -
APA
Silva Filho, C. R. da, Kondo, R. T. O., Chignalia, A. Z., López, K. J. V., Pereira, V. A., Carmona, M. J. C., et al. (2007). Quantification of propofol in smallvolumes of plasma using high-performance liquid chromatography with fluorescence detection: therapeutic drug monitoring of one patient. Latin American Journal of Pharmacy = Acta Farmacéutica Bonaerense, 26( 5), 748-754. -
NLM
Silva Filho CR da, Kondo RTO, Chignalia AZ, López KJV, Pereira VA, Carmona MJC, Auler Júnior JOC, Santos SRCJ. Quantification of propofol in smallvolumes of plasma using high-performance liquid chromatography with fluorescence detection: therapeutic drug monitoring of one patient. Latin American Journal of Pharmacy = Acta Farmacéutica Bonaerense. 2007 ;26( 5): 748-754.[citado 2026 mar. 05 ] -
Vancouver
Silva Filho CR da, Kondo RTO, Chignalia AZ, López KJV, Pereira VA, Carmona MJC, Auler Júnior JOC, Santos SRCJ. Quantification of propofol in smallvolumes of plasma using high-performance liquid chromatography with fluorescence detection: therapeutic drug monitoring of one patient. Latin American Journal of Pharmacy = Acta Farmacéutica Bonaerense. 2007 ;26( 5): 748-754.[citado 2026 mar. 05 ] - Micrométodo para quantificação de cefuroxima em plasma através da cromatografia líquida de alta eficiência: Aplicação na profilaxia de pacientes submetidos à cirurgia cardíaca
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- Influência da circulação extracorpórea sobre as concentrações plasmáticas de Atenolol
- Alteração da resposta farmacodinâmica do propofol na cirurgia de revascularização do miocárdio com circulação extra-corpórea
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