Effect of a combined oral contraceptive containing 20ug ethinyl estradiol and 75 ug gestodene on hemostatic parameters

Effect of a combined oral contraceptive containing 20ug ethinyl estradiol and 75 ug gestodene on hemostatic parameters (2006)

Authors:
Autor USP: ALDRIGHI, JOSE MENDES - FSP
Unidade: FSP
DOI: 10.1080/09513590500430328
Subjects: DISPOSITIVOS ANTICONCEPCIONAIS FEMININOS; HEMOSTASIA; TROMBOEMBOLISMO; RISCO
Language: Inglês
Abstract: The effects of a combined oral contraceptive (COC) containing 20 ug ethinyl estradiol (EE) and 75 ug gestodene (GSD) on prothrombin activity (PA), activated partial thromboplastin time (APTT), thrombin time (TT), platelet number, fibrinogen, antithrombin III (ATIII), protein C, protein S and D-dimer were evaluated over 6 months in 23 young, healthy women. Laboratory assessments were performed prior to initiation of COC use (pretreatment) and after 3 and 6 months of use. Results showed no significant changes in fibrinogen, protein C, ATIII or D-dimer during COC use, compared with pretreatment values. The increase in platelet count, decreases in protein S level, PA and APTT, and the prolongation of TT were significant. In conclusion, the use of a COC containing 20 ug EE and 75 ug GSD did not cause any significant changes in the hemostatic parameters studied that could be suggestive of a higher prothrombotic risk. Further studies with a larger sample size are necessary in order to obtain conclusive data
Imprenta:
- Publisher place: Carnforth
- Date published: 2006
Source:
- Título do periódico: Gynecological Endocrinology
- ISSN: 0951-3590
- Volume/Número/Paginação/Ano: v. 22, n. 1, p. 1-4, 2006

Informações sobre o DOI: 10.1080/09513590500430328 (Fonte: oaDOI API)

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ABNT

ALDRIGHI, José Mendes et al. Effect of a combined oral contraceptive containing 20ug ethinyl estradiol and 75 ug gestodene on hemostatic parameters. Gynecological Endocrinology, v. 22, n. 1, p. 1-4, 2006Tradução . . Disponível em: https://doi.org/10.1080/09513590500430328. Acesso em: 19 set. 2024.
APA

Aldrighi, J. M., Campos, L. S. C. de, Gebara, O. C. E., Petta, C. A., & Bahamondes, L. (2006). Effect of a combined oral contraceptive containing 20ug ethinyl estradiol and 75 ug gestodene on hemostatic parameters. Gynecological Endocrinology, 22( 1), 1-4. doi:10.1080/09513590500430328
NLM

Aldrighi JM, Campos LSC de, Gebara OCE, Petta CA, Bahamondes L. Effect of a combined oral contraceptive containing 20ug ethinyl estradiol and 75 ug gestodene on hemostatic parameters [Internet]. Gynecological Endocrinology. 2006 ; 22( 1): 1-4.[citado 2024 set. 19 ] Available from: https://doi.org/10.1080/09513590500430328
Vancouver

Aldrighi JM, Campos LSC de, Gebara OCE, Petta CA, Bahamondes L. Effect of a combined oral contraceptive containing 20ug ethinyl estradiol and 75 ug gestodene on hemostatic parameters [Internet]. Gynecological Endocrinology. 2006 ; 22( 1): 1-4.[citado 2024 set. 19 ] Available from: https://doi.org/10.1080/09513590500430328