Vitamin D receptor gene polymorphism and bone mineral density in hypercalciuric calcium-stone-forming patients (2002)
- Autor USP: MARTINI, LIGIA ARAUJO - FSP
- Unidade: FSP
- Subjects: CÁLCIO (URINA); CÁLCULOS URINÁRIOS; OSTEOPATIAS METABÓLICAS; DENSITOMETRIA ÓSSEA; VITAMINA D; POLIMORFISMO (GENÉTICA)
- Language: Inglês
- Abstract: Reduced bone mineral density (BMD) and an increased risk of vertebral fracture have been reported in calcium-stone-forming (CSF) patients presenting with idiopathic hypercalciuria. We investigated the association between BsmI vitamin D receptor (VDR) polymorphism and BMD in 68 hypercalciuric CSF patients (35 males and 33 premenopausal females, mean age ± SD = 39 ± 10 years). BMD was measured at lumbar spine (L2-L4) and femur neck sites using dual energy X-ray absorptiometry. A 72-hour dietary record and a 24-hour urine sample were obtained from each patient to determine calcium intake and excretion. The allelic frequency found for the sample as a whole was 16 percent BB, 44 percent Bb and 40 percent bb. Mean BMD values did not significantly differ among BB, Bb and bb patients at L2-L4 (1.162 ± 0.10, 1.133 ± 0.11 and 1.194 ± 0.19 g/cm2, mean ± SD, respectively) or at neck sites (0.920 ± 0.11, 0.931 ± 0.15 and 0.982 ± 0.15 g/cm2, respectively). Calcium intake and excretion were also not significantly different among the three genotypes. Patients were then divided into two groups, normal BMD, T-score -1 (n = 34) and low BMD, T-score <-1 (n = 34), to further evaluate the allele influence on previous bone loss. Despite a trend for a higher mean BMD at spine or neck sites for patients with one or two b alleles when compared to BB patients, the difference did not reach statistical significance. The distribution of BB, Bb and bb genotypes in the low-bone-mass group (15,47 and 38 percent, respectively) was similar to that in the normal-bone-mass group (18, 41 and 14 percent, respectively). These data suggest that BsmI VDR polymorphism does not play an important role in the bone loss seen in hypercalciuric CSF patients
ABNTHEILBERG, Ita Pfeferman; TEIXEIRA, Sergio Henrique; MARTINI, Lígia Araújo; BOIM, Mirian Aparecida. Vitamin D receptor gene polymorphism and bone mineral density in hypercalciuric calcium-stone-forming patients. Nephron, Basel, v. 90, n. 1, p. 51-57, 2002.
APAHeilberg, I. P., Teixeira, S. H., Martini, L. A., & Boim, M. A. (2002). Vitamin D receptor gene polymorphism and bone mineral density in hypercalciuric calcium-stone-forming patients. Nephron, 90( 1), 51-57.
NLMHeilberg IP, Teixeira SH, Martini LA, Boim MA. Vitamin D receptor gene polymorphism and bone mineral density in hypercalciuric calcium-stone-forming patients. Nephron. 2002 ; 90( 1): 51-57.
VancouverHeilberg IP, Teixeira SH, Martini LA, Boim MA. Vitamin D receptor gene polymorphism and bone mineral density in hypercalciuric calcium-stone-forming patients. Nephron. 2002 ; 90( 1): 51-57.
- Intervenção nutricional em mulheres com osteoporose: comparação entre adequação dietética e suplementação
- Risk factors for osteoporotic fractures in Brazilian men and women: the BRAZilian Osteoporosis Study (BRAZOS)
- Densidade mineral óssea, composição corporal e ingestão alimentar de adolescentes modelos de passarela
- Isoflavones and soya foods intakes in Brazilian population: data from the BRAZOS study
- Nutrient intakes related to bone mineral density in Brazilian men and women: the BRAZilian Osteoporosis Study (BRAZOS)
- Consumo alimentar e composição corporal de mulheres com elevada densidade óssea
- Vitamina D e doenças crônicas não transmissíveis
- Vitamina D na interação entre osso e tecido adiposo em adolescentes: osteocalcina, relação adiponectina / leptina e perfil lipídico
- Uso das recomendações nutricionais nas diferentes fases da vida da mulher
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas