Artigo de periodico

Acute administration of 17 beta-estradiol improves endothelium-dependent vasodilation in postmenopausal women (2005)

• Authors:
  • Lima, Sônia Maria Rolim Rosa
  • Aldrighi, José Mendes
  • Consolim-Colombo, Fernanda Marciano
  • Mansur, Antonio de Padua
  • Rubira, Marcelo Custódio
  • Krieger, Eduardo Moacyr
  • Ramires, José Antônio Franchini
• USP affiliated authors: RAMIRES, JOSE ANTONIO FRANCHINI - FM ; ALDRIGHI, JOSE MENDES - FSP ; KRIEGER, EDUARDO MOACYR - FM
• Unidades: FM; FSP
• DOI: 10.1016/j.maturitas.2004.05.010
• Subjects: MENOPAUSA; MULHERES; ESTEROIDES (APLICAÇÕES TERAPÊUTICAS); HIPERTENSÃO; FLUXO SANGUÍNEO REGIONAL; ENDOTÉLIO VASCULAR; ACETILCOLINA
• Language: Inglês
• Abstract: Objectives: Estrogen's effect on endothelial function in postmenopausal women with mild hypertension but no other cardiovascular risk factors remains unclear. This study investigated the effect of an acutely administered therapeutic/low dose of 17 beta-estradiol on vasodilation in this patient population. Methods: Forearm blood flow (FBF) was measured in seven white, hypertensive (blood pressure 144 ± 8/93 ± 5 mmHg), postmenopausal (mean age: 54.4 ± 5 years) women at baseline and during the intra-brachial infusion of increasing doses of acetylcholine (ACh; 0.75, 5, and 15 ug/100 mL tissue/min) and sodium nitroprusside (NP; 1, 2, and 4 ug/100 mL tissue/min). These measurements were obtained both before and after the sublingual administration of 17 beta-estradiol. Eight normotensive women (blood pressure 115 ± 8/76 ± 5 mmHg) with otherwise similar characteristics served as controls (mean age: 55.8 ± 5 years). Exclusion criteria included medications or any condition that could alter endothelial function. Results: Before estradiol administration, FBF values at baseline and after all doses of ACh and NP were similar between groups. Acutely administered 17 beta-estradiol significantly improved the FBF response to ACh in both the normotensive (maximal response: 17.6 ± 5 versus 22.5 ± 7 mL/min/100 mL) and hypertensive (11 ± 4 versus 16 ± 6; 12 ± 4 versus 17 ± 5 and 14 ± 3 versus 20 ± 7 mL/min/100 mL) groups. It also altered the NP dose-response curve in the bothgroups. Conclusion: 17 beta-estradiol improved vasodilatory responses in mildly hypertensive postmenopausal women without other risk factors for cardiovascular disease
• Imprenta:
  • Publisher place: Ireland
  • Date published: 2005
• Source:
  • Título do periódico: Maturita
  • ISSN: 0378-5122
  • Volume/Número/Paginação/Ano: v.50, p. 266–274, 2005

Informações sobre o DOI: 10.1016/j.maturitas.2004.05.010 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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• ABNT

  LIMA, Sônia Maria Rolim Rosa; ALDRIGHI, José Mendes; CONSOLIM-COLOMBO, Fernanda Marciano; et al. Acute administration of 17 beta-estradiol improves endothelium-dependent vasodilation in postmenopausal women. Maturita, Ireland, v. 50, p. 266–274, 2005. Disponível em: < https://ac.els-cdn.com/S0378512204001823/1-s2.0-S0378512204001823-main.pdf?_tid=78a5a530-30f6-4fa5-b990-5d9735527e63&acdnat=1530644662_1ac8df5ad948308ad47311036677795a > DOI: 10.1016/j.maturitas.2004.05.010.

• APA

  Lima, S. M. R. R., Aldrighi, J. M., Consolim-Colombo, F. M., Mansur, A. de P., Rubira, M. C., Krieger, E. M., & Ramires, J. A. F. (2005). Acute administration of 17 beta-estradiol improves endothelium-dependent vasodilation in postmenopausal women. Maturita, 50, 266–274. doi:10.1016/j.maturitas.2004.05.010

• NLM

  Lima SMRR, Aldrighi JM, Consolim-Colombo FM, Mansur A de P, Rubira MC, Krieger EM, Ramires JAF. Acute administration of 17 beta-estradiol improves endothelium-dependent vasodilation in postmenopausal women [Internet]. Maturita. 2005 ;50 266–274.Available from: https://ac.els-cdn.com/S0378512204001823/1-s2.0-S0378512204001823-main.pdf?_tid=78a5a530-30f6-4fa5-b990-5d9735527e63&acdnat=1530644662_1ac8df5ad948308ad47311036677795a

• Vancouver

  Lima SMRR, Aldrighi JM, Consolim-Colombo FM, Mansur A de P, Rubira MC, Krieger EM, Ramires JAF. Acute administration of 17 beta-estradiol improves endothelium-dependent vasodilation in postmenopausal women [Internet]. Maturita. 2005 ;50 266–274.Available from: https://ac.els-cdn.com/S0378512204001823/1-s2.0-S0378512204001823-main.pdf?_tid=78a5a530-30f6-4fa5-b990-5d9735527e63&acdnat=1530644662_1ac8df5ad948308ad47311036677795a

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