Acute administration of 17 beta-estradiol improves endothelium-dependent vasodilation in postmenopausal women (2005)
- Authors:
- USP affiliated authors: RAMIRES, JOSE ANTONIO FRANCHINI - FM ; ALDRIGHI, JOSE MENDES - FSP ; KRIEGER, EDUARDO MOACYR - FM
- Unidades: FM; FSP
- DOI: 10.1016/j.maturitas.2004.05.010
- Subjects: MENOPAUSA; MULHERES; ESTEROIDES (APLICAÇÕES TERAPÊUTICAS); HIPERTENSÃO; FLUXO SANGUÍNEO REGIONAL; ENDOTÉLIO VASCULAR; ACETILCOLINA
- Language: Inglês
- Abstract: Objectives: Estrogen's effect on endothelial function in postmenopausal women with mild hypertension but no other cardiovascular risk factors remains unclear. This study investigated the effect of an acutely administered therapeutic/low dose of 17 beta-estradiol on vasodilation in this patient population. Methods: Forearm blood flow (FBF) was measured in seven white, hypertensive (blood pressure 144 ± 8/93 ± 5 mmHg), postmenopausal (mean age: 54.4 ± 5 years) women at baseline and during the intra-brachial infusion of increasing doses of acetylcholine (ACh; 0.75, 5, and 15 ug/100 mL tissue/min) and sodium nitroprusside (NP; 1, 2, and 4 ug/100 mL tissue/min). These measurements were obtained both before and after the sublingual administration of 17 beta-estradiol. Eight normotensive women (blood pressure 115 ± 8/76 ± 5 mmHg) with otherwise similar characteristics served as controls (mean age: 55.8 ± 5 years). Exclusion criteria included medications or any condition that could alter endothelial function. Results: Before estradiol administration, FBF values at baseline and after all doses of ACh and NP were similar between groups. Acutely administered 17 beta-estradiol significantly improved the FBF response to ACh in both the normotensive (maximal response: 17.6 ± 5 versus 22.5 ± 7 mL/min/100 mL) and hypertensive (11 ± 4 versus 16 ± 6; 12 ± 4 versus 17 ± 5 and 14 ± 3 versus 20 ± 7 mL/min/100 mL) groups. It also altered the NP dose-response curve in the bothgroups. Conclusion: 17 beta-estradiol improved vasodilatory responses in mildly hypertensive postmenopausal women without other risk factors for cardiovascular disease
- Imprenta:
- Source:
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ABNT
LIMA, Sônia Maria Rolim Rosa et al. Acute administration of 17 beta-estradiol improves endothelium-dependent vasodilation in postmenopausal women. Maturita, v. 50, p. 266–274, 2005Tradução . . Disponível em: https://doi.org/10.1016/j.maturitas.2004.05.010. Acesso em: 20 abr. 2024. -
APA
Lima, S. M. R. R., Aldrighi, J. M., Consolim-Colombo, F. M., Mansur, A. de P., Rubira, M. C., Krieger, E. M., & Ramires, J. A. F. (2005). Acute administration of 17 beta-estradiol improves endothelium-dependent vasodilation in postmenopausal women. Maturita, 50, 266–274. doi:10.1016/j.maturitas.2004.05.010 -
NLM
Lima SMRR, Aldrighi JM, Consolim-Colombo FM, Mansur A de P, Rubira MC, Krieger EM, Ramires JAF. Acute administration of 17 beta-estradiol improves endothelium-dependent vasodilation in postmenopausal women [Internet]. Maturita. 2005 ;50 266–274.[citado 2024 abr. 20 ] Available from: https://doi.org/10.1016/j.maturitas.2004.05.010 -
Vancouver
Lima SMRR, Aldrighi JM, Consolim-Colombo FM, Mansur A de P, Rubira MC, Krieger EM, Ramires JAF. Acute administration of 17 beta-estradiol improves endothelium-dependent vasodilation in postmenopausal women [Internet]. Maturita. 2005 ;50 266–274.[citado 2024 abr. 20 ] Available from: https://doi.org/10.1016/j.maturitas.2004.05.010 - Acute administration of 17 'beta'-estradiol potentiated both endothelium-dependent and-independent vasodilation in normotensive and hypertensive menopausal women
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Informações sobre o DOI: 10.1016/j.maturitas.2004.05.010 (Fonte: oaDOI API)
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