Artigo de periodico

Postmenopausal hormone replacement therapy increases plasmatic thromboxane beta2 (2005)

• Authors:
  • Oliveira, Rute Loreto Sampaio de
  • Aldrighi, José Mendes
  • Gebara, Otávio E.
  • Rocha, Tania Rubia Flores da
  • D'Amico, Elbio Antonio
  • Rosano, Giuseppe M. C.
  • Ramires, José Antonio F.
• USP affiliated authors: ALDRIGHI, JOSE MENDES - FSP ; RAMIRES, JOSE ANTONIO FRANCHINI - FM
• Unidades: FSP; FM
• DOI: 10.1016/j.ijcard.2004.10.009
• Subjects: MENOPAUSA; TERAPIA DA REPOSIÇÃO HORMONAL (EFEITOS ADVERSOS); TROMBOXANOS (SANGUE); MOLÉCULAS DE ADESÃO CELULAR; ATIVAÇÃO DE PLAQUETAS; MULHERES
• Language: Inglês
• Abstract: Objective: This study shows the effect of hormone replacement therapy (HRT), using oral estrogen exclusively or in combination with progestin, on platelet activation in healthy menopaused women. Background:Recent evidence from studies of postmenopausal HRT in healthy women demonstrated a short-time increased risk of coronary heart disease. Platelet activation, which generates vasoconstrictory thromboxane A2 (TxA2), has been related to the risk of cardiovascular diseases.Methods: By means of a placebo-controlled study twenty-seven postmenopausal patients were continuously orally administered estrogen in combination with progestin or estrogen exclusively for an 8-week period. Platelet activation was evaluated by flow cytometric P-selectin expression and by enzyme immunoassay plasmatic TxA2 (TxB2) concentrations.Results: P-selectin binding index changed from 6.3±3.6 to 7.0±3 in the placebo group (n=10); from 5.9+2.2 to 7.9±3.3 in the E+P group (n=8) and from 6.4+2.7 to 7.1±1.9 in the E group (n=9). Plasma concentrations of TxB2 before and after intervention, changed from 1.2+1.2 to 1.5+1.4 (pg/well) in the placebo group; significantly (p=0.005) in the E+P group (n=8), from 0.9+0.3 to 6.1+6.5 (pg/well), and from 1.3+1.5 to 0.8+0.4 (pg/well) in the E group (n=8; mean+standard deviation, basal×therapy, p<0.05).Conclusions: Healthy menopaused women who were administered estradiol in association with norethisterone continuously had an increase of plasmaticthromboxane, possibly determined by platelet activation, which indicates a higher short-term thrombotic risk. P-selectin expression analyses failed to demonstrate the impact of HRT on platelets
• Imprenta:
  • Publisher place: Amsterdam
  • Date published: 2005
• Source:
  • Título: International Journal of Cardiology
  • ISSN: 0167-5273
  • Volume/Número/Paginação/Ano: v. 99, n. 3, p. 449-454, 2005

Informações sobre o DOI: 10.1016/j.ijcard.2004.10.009 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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• ABNT

  OLIVEIRA, Rute Loreto Sampaio de et al. Postmenopausal hormone replacement therapy increases plasmatic thromboxane beta2. International Journal of Cardiology, v. 99, n. 3, p. 449-454, 2005Tradução . . Disponível em: https://doi.org/10.1016/j.ijcard.2004.10.009. Acesso em: 18 nov. 2024.

• APA

  Oliveira, R. L. S. de, Aldrighi, J. M., Gebara, O. E., Rocha, T. R. F. da, D'Amico, E. A., Rosano, G. M. C., & Ramires, J. A. F. (2005). Postmenopausal hormone replacement therapy increases plasmatic thromboxane beta2. International Journal of Cardiology, 99( 3), 449-454. doi:10.1016/j.ijcard.2004.10.009

• NLM

  Oliveira RLS de, Aldrighi JM, Gebara OE, Rocha TRF da, D'Amico EA, Rosano GMC, Ramires JAF. Postmenopausal hormone replacement therapy increases plasmatic thromboxane beta2 [Internet]. International Journal of Cardiology. 2005 ; 99( 3): 449-454.[citado 2024 nov. 18 ] Available from: https://doi.org/10.1016/j.ijcard.2004.10.009

• Vancouver

  Oliveira RLS de, Aldrighi JM, Gebara OE, Rocha TRF da, D'Amico EA, Rosano GMC, Ramires JAF. Postmenopausal hormone replacement therapy increases plasmatic thromboxane beta2 [Internet]. International Journal of Cardiology. 2005 ; 99( 3): 449-454.[citado 2024 nov. 18 ] Available from: https://doi.org/10.1016/j.ijcard.2004.10.009

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