Effects of soy germ isoflavones and hormone therapy on nitric oxide derivatives, low-density lipoprotein oxidation, and vascular reactivity in hypercholesterolemic postmenopausal women (2006)
- Authors:
- USP affiliated authors: ALDRIGHI, JOSE MENDES - FSP ; ABDALLA, DULCINEIA SAES PARRA - FCF
- Unidades: FSP; FCF
- DOI: 10.1097/01.gme.0000248703.22581.8a
- Subjects: MENOPAUSA; HIPERCOLESTEROLEMIA; FLAVONÓIDES (APLICAÇÕES TERAPÊUTICAS); SOJA; ÓXIDO NÍTRICO (SANGUE); METABOLISMO ENERGÉTICO; LIPOPROTEÍNAS LDL; TERAPIA DA REPOSIÇÃO HORMONAL
- Language: Inglês
- Abstract: Objective: To evaluate the effects of soy germ isoflavones and hormone therapy on vascular reactivity, the formation of nitric oxide derivatives, and lipid peroxidation in hypercholesterolemic postmenopausal women.Design: Women were treated with soy germ, 17[beta]-estradiol or 17[beta]-estradiol + noretisterone acetate for 3 months after taking placebo for 1 month. The plasma concentrations of nitrite + nitrate and S-nitrosothiols were evaluated by gaseous phase chemiluminescence; nitrotyrosine, electronegative low-density lipoprotein, and estradiol levels were determined by enzyme-linked immunosorbent assay; cholesterol oxides and isoflavones were determined by gas chromatography and high-performance liquid chromatography, respectively. Vascular reactivity was analyzed by high-resolution ultrasonography. Results: Soy germ isoflavones and hormone therapy induced a decrease in nitrite + nitrate, electronegative low-density lipoprotein, and cholesterol oxides, as well as an increase in S-nitrosothiols. Soy germ isoflavones lowered electronegative low-density lipoprotein, and cholesterol oxides more efficiently than did hormone therapy. Only soy isoflavones inhibited nitrotyrosine formation. A significant improvement of vascular reactivity was only seen in women treated with 17[beta]-estradiol. Conclusions: The soy germ isoflavones and 17[beta]-estradiol, alone or associated with noretisterone acetate, in the doses and forms used here, have similar effects on thebioavailability of nitric oxide. Soy germ treatment inhibited lipid peroxidation more effectively than hormone therapy
- Imprenta:
- Source:
- Título do periódico: Menopause - The Journal of the North American Menopause Society
- ISSN: 1072-3714
- Volume/Número/Paginação/Ano: v. 13, n. 6, p. 942-950, 2006
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
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ABNT
PEREIRA, Isabela Rosier Olimpio et al. Effects of soy germ isoflavones and hormone therapy on nitric oxide derivatives, low-density lipoprotein oxidation, and vascular reactivity in hypercholesterolemic postmenopausal women. Menopause - The Journal of the North American Menopause Society, v. 13, n. 6, p. 942-950, 2006Tradução . . Disponível em: https://doi.org/10.1097/01.gme.0000248703.22581.8a. Acesso em: 23 abr. 2024. -
APA
Pereira, I. R. O., Faludi, A. A., Aldrighi, J. M., Bertolami, M. C., Saleh, M. H., Silva, R. A., et al. (2006). Effects of soy germ isoflavones and hormone therapy on nitric oxide derivatives, low-density lipoprotein oxidation, and vascular reactivity in hypercholesterolemic postmenopausal women. Menopause - The Journal of the North American Menopause Society, 13( 6), 942-950. doi:10.1097/01.gme.0000248703.22581.8a -
NLM
Pereira IRO, Faludi AA, Aldrighi JM, Bertolami MC, Saleh MH, Silva RA, Nakamura Y, Campos MF, Novaes N, Abdalla DSP. Effects of soy germ isoflavones and hormone therapy on nitric oxide derivatives, low-density lipoprotein oxidation, and vascular reactivity in hypercholesterolemic postmenopausal women [Internet]. Menopause - The Journal of the North American Menopause Society. 2006 ; 13( 6): 942-950.[citado 2024 abr. 23 ] Available from: https://doi.org/10.1097/01.gme.0000248703.22581.8a -
Vancouver
Pereira IRO, Faludi AA, Aldrighi JM, Bertolami MC, Saleh MH, Silva RA, Nakamura Y, Campos MF, Novaes N, Abdalla DSP. Effects of soy germ isoflavones and hormone therapy on nitric oxide derivatives, low-density lipoprotein oxidation, and vascular reactivity in hypercholesterolemic postmenopausal women [Internet]. Menopause - The Journal of the North American Menopause Society. 2006 ; 13( 6): 942-950.[citado 2024 abr. 23 ] Available from: https://doi.org/10.1097/01.gme.0000248703.22581.8a - Nitric oxide inactivation in postmenopausal woman
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- Peroxidação lipídica e inativação do óxido nítrico na pós-menopausa
- Efeitos dos fitoestrógenos da soja e da terapia de reposição hormonal sobre a formação de 'ANTPOT. PONTO NO' homocisteína e óxidos de colesterol em mulheres pós-menopausa hipercolesterolêmicas
- Lipid peroxidation and nitric oxide inactivation in postmenopausal women
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- Lipid hydroperoxides and oxysterols in postmenopausal women
Informações sobre o DOI: 10.1097/01.gme.0000248703.22581.8a (Fonte: oaDOI API)
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