Characterization of the inflammatory response in syngeneic and allogeneic skin transplantation in BALB/C mice (2006)
- Authors:
- Autor USP: RIZZO, LUIZ VICENTE - ICB
- Unidade: ICB
- Assunto: IMUNOLOGIA
- Language: Inglês
- Abstract: Introduction and Objectives: The process of graft rejection is complex and involves a diversity of populations and mechanisms. The response is triggered by signals due to damage caused by surgery, afterwards the recognition of alloantigens leads to effector mechanisms which increase the inflammatory response and affects the allograft. The role of inflammation in transplantation is still not entirely understood. In this study, we characterize the inflammatory cells that migrate to allogeneic or syngeneic skin grafts after transplantation and investigate if there is an increase of allograft survival when transplanted simultaneously with the syngeneic graft. Methods and Results: BALB/c mice (H-2d) were transplanted with the tail skin from syngeneic or allogeneic donors (NZW;H-2z). Grafts were removed at 24, 72 hours, 7 or 9 days after transplantation and cultured in 500 µL of complete medium for 24 hours. Cells that emigrated from the grafts were characterized by cytospin and flow cytometry. IL-10 and NO production were evaluated in the supernatants.Syngeneic and allogeneic skin grafts were also transplanted simultaneously into recipients and graft survival was evaluated. Results show an increase of total number of emigrant cells during the evaluation period both in syngeneic and allogeneic grafts. The majority of the population was composed of neutrophils at all time-points although an increase of mononuclear cells was observed from day 1 untilday 7. A higher production of nitric oxide in allogeneic skin was observed in all time-points when compared to syngeneic grafts; IL-10 production was higher in syngeneic graft in the first 24 hours. In receptors of simultaneous transplantation, allograft survival was increased when compared to mice that received allografts only. Conclusion: These data suggest differential regulatory mechanism in allogeneic and syngeneic grafts and that increased allograft survival may be a consequence of the bystander suppression due to syngeneic graft.
- Imprenta:
- Source:
- Título: Abstracts
- Conference titles: Meeting of the Brazilian Society for Immunology
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ABNT
TAKIISHI, T e RIZZO, Luiz Vicente e MORAES, L V. Characterization of the inflammatory response in syngeneic and allogeneic skin transplantation in BALB/C mice. 2006, Anais.. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2006. . Acesso em: 22 jan. 2026. -
APA
Takiishi, T., Rizzo, L. V., & Moraes, L. V. (2006). Characterization of the inflammatory response in syngeneic and allogeneic skin transplantation in BALB/C mice. In Abstracts. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Takiishi T, Rizzo LV, Moraes LV. Characterization of the inflammatory response in syngeneic and allogeneic skin transplantation in BALB/C mice. Abstracts. 2006 ;[citado 2026 jan. 22 ] -
Vancouver
Takiishi T, Rizzo LV, Moraes LV. Characterization of the inflammatory response in syngeneic and allogeneic skin transplantation in BALB/C mice. Abstracts. 2006 ;[citado 2026 jan. 22 ] - Combined immunodeficiency in a chilhood with Cd3 deficiency: case report
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