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Ordered mesoporous silica SBA-15:: an attractice nanoparticle for modulation of immune responses (2006)

  • Authors:
  • USP affiliated author: SCIVOLETTO, REGINA - ICB
  • School: ICB
  • Subject: FARMACOLOGIA
  • Language: Inglês
  • Abstract: Introduction and Objectives: The ordered mesoporous silica SBA-15 has been synthesized under acidic conditions by self-assembly of silica species with the tri-block copolymer as a structure-directing agent. The SBA-15 possesses hexagonal porous uniformity, thermal and hydrothermal stability and exhibits potential applications ranging from adsorption and catalysis. Based in its physical and structural properties the aim of this work is evaluate its efficiency to act as vehicle for immunogens and its capacity on modulation of immuneresponsiveness. Methods and Results: Mice genetically selected for high or low antibody response (HIVA or LIVA) with 2-3 month old were immunized with different concentrations (0.1, 1, 10 or 100µg/animal in final volume of 0,2ml) of Serum Bovine Albumin (BSA) in SBA-15, or Al(OH)3, or in Incomplete of Freund Adjuvant (IFA) by the intramuscular or oral route. Blood was collected at different period after immunizations and ELISA was used for IgG titration.The silica SBA-15 was capable to improve and positively modulated the immune response of the low LIVA mice, which produced antibodies title similar to the HIVA. The IgG antibody titration obtained by at 14 days after immunization were: 10,0 ± 1,4 BSA:SBA-15 and 7,0 ± 0,8 BSA:Al(OH)3 for oral route; by intramuscular route were: 12,1 ± 0,9 BSA:SBA-15 and 11,1 ± 0,9 BSA:IFA; while the mice HIVA immunized by the oral via the titles were: 9,5 ± 1,3 BSA:SBA-15and 10,7 ± 0,6 BSA:Al(OH)3 and by intramuscular route were: 11,2 ± 0,3 BSA:SBA-15 and 12,5 ± 0,5 BSA:IFA. Other in vitro experiments show the increase induction of yeasts phagocytosis after macrophage stimulation with these nanoparticules. Conclusion: The results demonstrated the ability the SBA-15 to increase the immunogenicity of antigens and positively modulate the immune response of the LIVA mice. Thus, SBA-15 seems to be a nanostructured particle useful for vaccine delivery, being capable to improve responsiveness which is safer and more effective.
  • Imprenta:
  • Source:
  • Conference title: Meeting of the Brazilian Society for Immunology

  • How to cite
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    • ABNT

      CARVALHO, L V et al. Ordered mesoporous silica SBA-15:: an attractice nanoparticle for modulation of immune responses. 2006, Anais.. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2006. . Acesso em: 08 ago. 2022.
    • APA

      Carvalho, L. V., Commodaro, A. G., Mercuri, L. P., Fantini, M. C. de A., Matos, J. R., Cabrera, W. H., et al. (2006). Ordered mesoporous silica SBA-15:: an attractice nanoparticle for modulation of immune responses. In Abstracts. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo.
    • NLM

      Carvalho LV, Commodaro AG, Mercuri LP, Fantini MC de A, Matos JR, Cabrera WH, Pagani E, Scivoletto R, Ribeiro OG, Tambourgi DV, Sant'Anna OA. Ordered mesoporous silica SBA-15:: an attractice nanoparticle for modulation of immune responses. Abstracts. 2006 ;[citado 2022 ago. 08 ]
    • Vancouver

      Carvalho LV, Commodaro AG, Mercuri LP, Fantini MC de A, Matos JR, Cabrera WH, Pagani E, Scivoletto R, Ribeiro OG, Tambourgi DV, Sant'Anna OA. Ordered mesoporous silica SBA-15:: an attractice nanoparticle for modulation of immune responses. Abstracts. 2006 ;[citado 2022 ago. 08 ]


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