Hierarchical suppression of asthma like responses by mucosal tolerance (2006)
- Autor:
- Autor USP: RUSSO, MOMTCHILO - ICB
- Unidade: ICB
- Assunto: IMUNOLOGIA
- Language: Inglês
- Abstract: Mucosal tolerance prevents exacerbated reactions against air or food borne antigens, and its failure might lead to atopic diseases such as asthma or food allergy. Here, we examined the effects of oral or nasal ovalbumin (OVA) exposure on the development of asthma like responses. Oral or nasal OVA administration before immunization suppressed airway eosinophilic inflammation and airway hyperreactivity, type-2 cytokine production, mucus formation and OVA-specific IgE production. Oral but not nasal OVA administration suppressed Ag-specific IgG1 antibodies. However, the IgG1 antibodies produced by animals exposed to nasal OVA did not induce passive cutaneous anaphylaxis reaction whereas those produced by immunized mice were anaphylactic. When the protocol for mucosal tolerance was initiated concomitantly with OVA immunization, oral or nasal OVA administration were equally effective in suppressing asthma-like responses. Interestingly; IgG1 OVA-specific antibodies were not suppressed but the production of IgE and IgG1 anaphylactic antibodies were significantly inhibited.Oral or nasal OVA exposure initiated 7 days after immunization was still effective in suppressing airway inflammation; airway hyperreactivity and mucus formation but did not suppress IgE or IgG1 anaphylactic antibodies. Finally, suppressive cytokines (TGFb and IL-10) were detected in the bronchoalveolar fluid of immunized but not in tolerized mice. Our resultsindicate that suppression of asthma like responses by mucosal tolerance is not associated with suppressive cytokines in the airways. Moreover, oral but not nasal tolerance initiated before immunization prevents the production of IgG1 antibodies. Furthermore, mucosal tolerance presents a hierarchical pattern of suppression in which airway inflammation, airway hyperreactivity and mucus production are more prone to suppression than the production of IgE and IgG1 anaphylactic antibodies.
- Imprenta:
- Source:
- Título: Abstracts
- Conference titles: Meeting of the Brazilian Society for Immunology
-
ABNT
RUSSO, Momtchilo. Hierarchical suppression of asthma like responses by mucosal tolerance. 2006, Anais.. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2006. . Acesso em: 05 jun. 2025. -
APA
Russo, M. (2006). Hierarchical suppression of asthma like responses by mucosal tolerance. In Abstracts. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Russo M. Hierarchical suppression of asthma like responses by mucosal tolerance. Abstracts. 2006 ;[citado 2025 jun. 05 ] -
Vancouver
Russo M. Hierarchical suppression of asthma like responses by mucosal tolerance. Abstracts. 2006 ;[citado 2025 jun. 05 ] - Participação de anticorpos de diferentes isotipos na alteração de preferência ao sabor induzida imunologicamente em camundongos: um estudo por meio da tolerância oral
- Induction of immune deviation on oral tolerance by leukotrienes inhibition
- Macrófago: da inflamação a imunidade
- Spontaneous and persistent release of hydrogen peroxide from peritoned macrophages during Trypanosoma cruzi infection
- Immunopathology of Trypanosoma cruzi infection in mouse selectively depleted of T helper lymphocytes
- Depletion of l3t4 + T lymphocytes during acute Trypanosoma cruzi infection abolish macrophage and B lymphocyte activation but not tissue inflammatory reaction
- Role of T lymphocytes and interferon-gama on macrophage activation and inflammatory response induced by in vivo con a lectin injection
- Indução da atividade citotóxica e produção de óxido nitrico (No) por macrófagos residentes co-cultivados com células tumorais l929
- Induction of oral tolerance to experimental asthma in BALB/c mice, a prototype to TH2-PRONE strain
- Modulation of murine experimental asthma by lipopolisaccharides
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
