Effects of mercury intoxication on the response of horizontal cells of the retina of thraira fish (Hopilas malabaricus) (2006)
- Authors:
- Tanan, C. L
- Ventura, Dora Selma Fix
- Souza, John Manuel de
- Grotzner, S. R - Universidade Federal do Paraná (UFPR)
- Mela, M. - Universidade Federal do Paraná (UFPR)
- Gouveia Júnior, Amauri - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
- Oliveira Ribeiro, C. A - Universidade Federal do Paraná (UFPR)
- USP affiliated authors: VENTURA, DORA SELMA FIX - IP ; SOUZA, JOHN MANUEL DE - IP
- Unidade: IP
- DOI: 10.1590/s0100-879x2006000700017
- Subjects: PEIXES; RETINA; TRAÍRA; NEUROCIÊNCIAS; BIOLOGIA CELULAR; PSICOLOGIA EXPERIMENTAL
- Language: Inglês
- Abstract: Methyl mercury (MeHg) is highly neurotoxic, affecting visual function in addition to other central nervous system functions. The effect of mercury intoxication on the amplitude of horizontal cell responses to light was studied in the retina of the fish Hoplias malabaricus. Intracellular responses were recorded from horizontal cells of fish previously intoxicated with MeHg by intraperitoneal injection (IP group) or by trophic exposure (T group). Only one retina per fish was used. The doses of MeHg chloride administered to the IP group were 0.01, 0.05, 0.1, 1.0, 2.0, and 6.0 mg/kg. The amplitudes of the horizontal cell responses were lower than control in individuals exposed to 0.01 (N = 4 retinas), 0.05 (N = 2 retinas) and 0.1 mg/kg (N = 1 retina), whereas no responses were recorded in the 1.0, 2.0, and 6.0 mg/kg groups. T group individuals were fed young specimens of Astyanax sp previously injected with MeHg corresponding to 0.75 (N = 1 retina), 0.075 (N = 8 retinas) or 0.0075 (N = 4 retinas) mg/kg fish body weight. After 14 doses, one every 5 days, the amplitude of the horizontal cell response was higher than control in individuals exposed to 0.075 and 0.0075 mg/kg, and lower in individuals exposed to 0.75 mg/kg. We conclude that intoxication with MeHg affects the electrophysiological response of the horizontal cells in the retina, either reducing or increasing its amplitude compared to control, and that these effects are related to the dose and/or to the mode ofadministration.
- Imprenta:
- Publisher place: Ribeirão Preto, SP
- Date published: 2006
- Source:
- Título: Brazilian Journal of Medical and Biological Research
- Volume/Número/Paginação/Ano: v. 39, n. 7, p. 987-995, 2006
- Este artigo possui versão em acesso aberto
- URL de acesso aberto
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- Versão do Documento: Versão publicada (Published version)
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Status: Artigo publicado em periódico de acesso aberto (Gold Open Access) -
ABNT
TANAN, C. L et al. Effects of mercury intoxication on the response of horizontal cells of the retina of thraira fish (Hopilas malabaricus). Brazilian Journal of Medical and Biological Research, v. 39, n. 7, p. 987-995, 2006Tradução . . Disponível em: https://doi.org/10.1590/s0100-879x2006000700017. Acesso em: 14 mar. 2026. -
APA
Tanan, C. L., Ventura, D. S. F., Souza, J. M. de, Grotzner, S. R., Mela, M., Gouveia Júnior, A., & Oliveira Ribeiro, C. A. (2006). Effects of mercury intoxication on the response of horizontal cells of the retina of thraira fish (Hopilas malabaricus). Brazilian Journal of Medical and Biological Research, 39( 7), 987-995. doi:10.1590/s0100-879x2006000700017 -
NLM
Tanan CL, Ventura DSF, Souza JM de, Grotzner SR, Mela M, Gouveia Júnior A, Oliveira Ribeiro CA. Effects of mercury intoxication on the response of horizontal cells of the retina of thraira fish (Hopilas malabaricus) [Internet]. Brazilian Journal of Medical and Biological Research. 2006 ; 39( 7): 987-995.[citado 2026 mar. 14 ] Available from: https://doi.org/10.1590/s0100-879x2006000700017 -
Vancouver
Tanan CL, Ventura DSF, Souza JM de, Grotzner SR, Mela M, Gouveia Júnior A, Oliveira Ribeiro CA. Effects of mercury intoxication on the response of horizontal cells of the retina of thraira fish (Hopilas malabaricus) [Internet]. Brazilian Journal of Medical and Biological Research. 2006 ; 39( 7): 987-995.[citado 2026 mar. 14 ] Available from: https://doi.org/10.1590/s0100-879x2006000700017 - Assessment of andapted version of the Cambridge Colour Test and preliminary study of colour vision in infants and children
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