Angiotensin II contributes to isoproterenol-induced cardiomyocyte hypertrophy in normotensive mice (2005)
- Authors:
- Autor USP: MICHELINI, LISETE COMPAGNO - ICB
- Unidade: ICB
- Assunto: FISIOLOGIA
- Language: Português
- Abstract: Objetivo: The objective of this study was to test the hypothesis that angiotensin II (Ang II) contributes to left ventricular ( LV ) hypertrophy in mice chronically administered isoproterenol (ISO). Métodos e Resultados: Male C57BL/6J mice (20-25g) received tap water (VEH) with or without the AT1 receptor blocker losartan (LOS, ~30 mg/kg/day) to drink. Three days later, the mice were injected with ISO (12 mg/kg/day, sc. for 7 days) or VEH (50 µl olive oil). On the 5th day of ISO treatment, mice were instrumented for direct measurement of arterial pressure (AP). After recording AP in the conscious state, the mice were euthanized with sodium pentobarbital (80 mg/kg, ip). Hearts were removed, weighed, and prepared for histological analysis. The width of cardiomyocytes was measured from 20 randomly selected fields from 6-8 transmural slices/heart using a computer-based morphometric system. LOS and ISO treatments did not significantly change AP. ISO increased cardiomyocyte size by 27% in VEH-treated mice (n=7, P<.05), but failed to change myocyte size in LOS-treated mice (+8%, n=6, NS). In contrast, ISO increased LV mass to a similar extent in LOS-treated (+23%, P<.05) and VEH-treated (+29%, P<.05) mice. Conclusões: We conclude that blockade of AT1 receptors with LOS prevents ISO-induced cardiomyocyte hypertrophy in normotensive mice, implicating Ang II as a mediator of hypertrophy in this model. The dissociation between myocyte and LV hypertrophywith LOS treatment suggests additional changes in the composition of the heart in this model
- Imprenta:
- Publisher: Federação de Sociedades de Biologia Experimental
- Publisher place: Águas de Lindóia, São Paulo
- Date published: 2005
- Source:
- Título: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE
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ABNT
SANTOS, C. M. e CHAPLEAU, M. W. e MICHELINI, Lisete Compagno. Angiotensin II contributes to isoproterenol-induced cardiomyocyte hypertrophy in normotensive mice. 2005, Anais.. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental, 2005. . Acesso em: 14 mar. 2026. -
APA
Santos, C. M., Chapleau, M. W., & Michelini, L. C. (2005). Angiotensin II contributes to isoproterenol-induced cardiomyocyte hypertrophy in normotensive mice. In Resumos. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental. -
NLM
Santos CM, Chapleau MW, Michelini LC. Angiotensin II contributes to isoproterenol-induced cardiomyocyte hypertrophy in normotensive mice. Resumos. 2005 ;[citado 2026 mar. 14 ] -
Vancouver
Santos CM, Chapleau MW, Michelini LC. Angiotensin II contributes to isoproterenol-induced cardiomyocyte hypertrophy in normotensive mice. Resumos. 2005 ;[citado 2026 mar. 14 ] - Exercise normalizes enhanced neuronal excitability of hypothalamic preautonomic neurons of hypertensive rats
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