Effect of physical preconditioning on the reactivity of mesenteric artery from rats submitted to pulmonary ischaemia-reperfusion (2005)
- Authors:
- Autor USP: NUCCI, GILBERTO DE - ICB
- Unidade: ICB
- Assunto: FARMACOLOGIA
- Language: Português
- Abstract: Objetivo: The aim of this study was to evaluate the effect of physical preconditioning on the reactivity of mesenteric artery from rats submitted to a pulmonary ischaemia-reperfusion (IR). Métodos e Resultados: Wistar male rats were divided into sham operated (SHAM); IR sedentary (IRSD) and IR trained (IRTR) groups. Run training (RT) was performed for 5 days/week, each session of 60 min during 8 weeks at intensity of 66% of VO2max. After RT, the animals were submitted to pulmonary IR for 90 min and reperfusion for 2 hours. Rats were sacrificed and the mesenteric artery ring was isolated. Concentration-response curves to acetylcholine (ACh), histamine (HIST), and phenylephrine (PHE) were obtained. IR reduced the potency for ACh (SHAM: 7.65±0.12; IRSD: 7.00±0.05; IRTR: 6.88±0.06) and for HIST (SHAM: 5.26±0.05; IRSD: 5.05±0.08; IRTR: 5.52±0.02). Neither potency nor Emax were altered for PHE. RT did not modify the potency for ACh, but produced a significantly increase of potency for HIST, about 3-fold. No changes in Emax were observed for ACh and HIST. Conclusões: Physical preconditioning for 8 weeks did not prevent the impairment of sensitivity of mesentery artery ring for ACh. In contrast, a super sensitivity of relaxing response for HIST was observed in mesenteric ring from trained groups
- Imprenta:
- Publisher: Federação de Sociedades de Biologia Experimental
- Publisher place: Águas de Lindóia, São Paulo
- Date published: 2005
- Source:
- Título: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE
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ABNT
MORAES, C. et al. Effect of physical preconditioning on the reactivity of mesenteric artery from rats submitted to pulmonary ischaemia-reperfusion. 2005, Anais.. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental, 2005. . Acesso em: 08 out. 2024. -
APA
Moraes, C., Camargo, E. A., Ferreira, T., Landucci, E. C. T., Kalaf, R., Antunes, E., et al. (2005). Effect of physical preconditioning on the reactivity of mesenteric artery from rats submitted to pulmonary ischaemia-reperfusion. In Resumos. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental. -
NLM
Moraes C, Camargo EA, Ferreira T, Landucci ECT, Kalaf R, Antunes E, De Nucci G, Zanesco A. Effect of physical preconditioning on the reactivity of mesenteric artery from rats submitted to pulmonary ischaemia-reperfusion. Resumos. 2005 ;[citado 2024 out. 08 ] -
Vancouver
Moraes C, Camargo EA, Ferreira T, Landucci ECT, Kalaf R, Antunes E, De Nucci G, Zanesco A. Effect of physical preconditioning on the reactivity of mesenteric artery from rats submitted to pulmonary ischaemia-reperfusion. Resumos. 2005 ;[citado 2024 out. 08 ] - Presence of nitric oxide synthase inhibitor activity in rat pleural exsudates
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