Effect of bay 41-2272 in the pulmonary hypertension induced by hypoxia in anaesthetized beagles (2005)
- Authors:
- Autor USP: NUCCI, GILBERTO DE - ICB
- Unidade: ICB
- Assunto: FARMACOLOGIA
- Language: Português
- Abstract: Objetivo: BAY 41-2272 has been reported as a novel NO-independent activator of the soluble guanylate cyclase. BAY 41-2272 relaxes aortic rings in vitro and reduces mean arterial blood pressure in normal and hypertensive rats. In this study, we investigated whether BAY 41-2272 counteracts the pulmonary hypertension (PH) induced by hypoxia in anaesthetized dogs. Métodos e Resultados: 12 male Beagles dogs (8-14 kg) were anaesthetized with pentobarbital sodium (30 mg/kg, i.v), and supplemented with fentanyl (10 µg/kg/h) and diazepam (700 µg/kg/h). In the hypoxia group, dogs were submitted to a 12% FiO2. The following parameters were evaluated: blood pressure (BP), heart rate (HR), PH, cardiac index (CI), index of systemic and pulmonar vascular resistance (ISVR), (IPVR). Hypoxia caused a marked PH (at 5 min: from 7.7±1.8 to 21.8±3.3 mmHg; P<0.01). This was accompanied by increases in CI (from 3.3±0.4 to 4.7±0.5 mmHg) and IPVR (125±12 to 250±32 D.s/cm5/m2). BAY 41-2272 (10 µg/kg/min, i.v.) prevented PH and the increases in IPVR and IC. Conclusões: Our results suggest prolonged stimulation of sGC in a NO-independent manner by BAY-412272 counteracts the vasoconstrictor mechanisms triggered by hypoxia at the pulmonary bed
- Imprenta:
- Publisher: Federação de Sociedades de Biologia Experimental
- Publisher place: Águas de Lindóia, São Paulo
- Date published: 2005
- Source:
- Título: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE
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ABNT
FREITAS, C. F. e DE NUCCI, Gilberto e ANTUNES, E. Effect of bay 41-2272 in the pulmonary hypertension induced by hypoxia in anaesthetized beagles. 2005, Anais.. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental, 2005. . Acesso em: 18 nov. 2024. -
APA
Freitas, C. F., De Nucci, G., & Antunes, E. (2005). Effect of bay 41-2272 in the pulmonary hypertension induced by hypoxia in anaesthetized beagles. In Resumos. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental. -
NLM
Freitas CF, De Nucci G, Antunes E. Effect of bay 41-2272 in the pulmonary hypertension induced by hypoxia in anaesthetized beagles. Resumos. 2005 ;[citado 2024 nov. 18 ] -
Vancouver
Freitas CF, De Nucci G, Antunes E. Effect of bay 41-2272 in the pulmonary hypertension induced by hypoxia in anaesthetized beagles. Resumos. 2005 ;[citado 2024 nov. 18 ] - Presence of nitric oxide synthase inhibitor activity in rat pleural exsudates
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