Role of nitric oxide on the cardiovascular responses produced by moxonidine in doca-salt hypertensive rats (2005)
- Authors:
- Autor USP: PASSAGLIA, RITA DE CASSIA ALEIXO TOSTES - ICB
- Unidade: ICB
- Assunto: FARMACOLOGIA
- Language: Português
- Abstract: Objetivo: Moxonidine is an alpha2-adrenergic/imidazoline receptor agonist. The anti-hypertensive effect of moxonidine is suggested to depend on a decrease in sympathetic nerve activity due to moxonidine action in the rostroventrolateral medulla. In normotensive Wistar rats, the reduction in mean arterial pressure (MAP) produced by central moxonidine is attenuated by blockade of central nitric oxide synthesis. In this study we evaluated the effects of the pretreatment with L-NAME (NO synthesis inhibitor) injected centrally on the cardiovascular responses produced by central moxonidine in conscious DOCA-salt hypertensive rats. Métodos e Resultados: Male Wistar rats (300-320 g at the time of the experiment) were previously nephrectomized unilaterally, treated with DOCA (50 mg/kg/wk) or vehicle over 8 weeks, and maintened with 0.9% NaCl + 1% KCl drink solution. Control rats were maintained with drinking water. A stainless steel cannula was implanted into the 4th brain ventricle (4th V) 5 days prior to the experiments. MAP and heart rate (HR) were recorded in conscious DOCA-salt rats that had an arterial cannula inserted into the femoral artery one day before the experiments. Moxonidine (20 nmol/1 uL) injected into 4th V elicited a greater fall in MAP (-59±3 mm Hg) and HR (-73±5 bpm) in DOCA-salt rats (N=7) compared to control normotensive rats (-27±2 mmHg and -34±2 bpm, N=8). Pretreatment with LNAME (20 nmol/1 uL) into the 4th V significantly attenuated thehypotension (-14±3 mmHg), but not the bradycardia (-73±12 bpm) evoked by moxonidine into the 4th V in DOCA-salt rats or in control normotensive rats (-19±7 mmHg and -55±16 bpm). Conclusões: Central nitric oxide is involved in the greater hypotension, but not in the bradycardic response evoked by moxonidine into the 4th V in DOCA-salt hypertensive rats
- Imprenta:
- Publisher: Federação de Sociedades de Biologia Experimental
- Publisher place: Águas de Lindóia, São Paulo
- Date published: 2005
- Source:
- Título: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE
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ABNT
COSTA, B. M. et al. Role of nitric oxide on the cardiovascular responses produced by moxonidine in doca-salt hypertensive rats. 2005, Anais.. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental, 2005. . Acesso em: 30 dez. 2025. -
APA
Costa, B. M., Moreira, T. dos S., Passaglia, R. de C. A. T., Menani, J. V., Colombari, E., & Sato, M. A. (2005). Role of nitric oxide on the cardiovascular responses produced by moxonidine in doca-salt hypertensive rats. In Resumos. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental. -
NLM
Costa BM, Moreira T dos S, Passaglia R de CAT, Menani JV, Colombari E, Sato MA. Role of nitric oxide on the cardiovascular responses produced by moxonidine in doca-salt hypertensive rats. Resumos. 2005 ;[citado 2025 dez. 30 ] -
Vancouver
Costa BM, Moreira T dos S, Passaglia R de CAT, Menani JV, Colombari E, Sato MA. Role of nitric oxide on the cardiovascular responses produced by moxonidine in doca-salt hypertensive rats. Resumos. 2005 ;[citado 2025 dez. 30 ] - ET-1-induced oxidative stress in doca-salt hypertension involves NAD(P)H oxidase-independent mechanisms
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