A novel effect for annexin 1-derived peptide AC2-26: reduction of allergic inflammation in the rat (2005)
- Authors:
- Autor USP: NUCCI, GILBERTO DE - ICB
- Unidade: ICB
- Assunto: FARMACOLOGIA
- Language: Português
- Abstract: Previous investigations have provided evidence that the N-terminal peptide of annexin 1 (peptide Ac2-26) has the capacity of reproducing the antiinflammatory actions of the full-length protein in many systems. In the current study, we report the effectiveness of the peptide Ac2-26 as an antiallergic tool in a model of rat pleurisy, and provide indication for some of the mechanisms involved. Methods and Results: In rats inflamed by injection of ovalbumin into the pleural cavity 14 days post-sensitization, peptide Ac2-26 (50-200 _g/cavity) inhibited mast cell desgranulation, plasma protein leakage, and the accumulation of both neutrophils and eosinophils. Treatment with either peptide Ac2-26 (200 _g/cavity) or dexamethasone (1 mg/kg, i.p.) inhibited ovalbumin-induced eotaxin release in the pleural effluents (545.1±162.6 to 18.2±18.2 and 5.0±5.0 fmol/cavity, respectively). In vitro, peptide Ac2-26 inhibited ovalbumin-evoked histamine release (62%) from subcutaneous tissue fragments obtained from sensitized rats (33-66 _M) and IL-13-evoked eotaxin generation (52%) from cultured rat mesothelial cells (16-33 _M) but not eosinophil chemotaxis evoked by either eotaxin or PAF. Conclusões: This work demonstrates that the annexin 1 mimetic peptide Ac2-26 prevents allergen-evoked eosinophilic inflammatory response in rats. Combined analysis of the in vivo and in vitro experiments here presented suggests that the blockade of secretion of pivotal mediators for theallergic response, such as histamine and eotaxin, could be responsible for the inhibitory actions displayed by peptide Ac2-26.
- Imprenta:
- Publisher: Federação de Sociedades de Biologia Experimental
- Publisher place: Águas de Lindóia, São Paulo
- Date published: 2005
- Source:
- Título do periódico: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE
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ABNT
CARDOSO, M. H. M. et al. A novel effect for annexin 1-derived peptide AC2-26: reduction of allergic inflammation in the rat. 2005, Anais.. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental, 2005. . Acesso em: 19 abr. 2024. -
APA
Cardoso, M. H. M., Marcondes, S., Lila, S., De Nucci, G., Turko, I. V., Murad, F., & Antunes, E. (2005). A novel effect for annexin 1-derived peptide AC2-26: reduction of allergic inflammation in the rat. In Resumos. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental. -
NLM
Cardoso MHM, Marcondes S, Lila S, De Nucci G, Turko IV, Murad F, Antunes E. A novel effect for annexin 1-derived peptide AC2-26: reduction of allergic inflammation in the rat. Resumos. 2005 ;[citado 2024 abr. 19 ] -
Vancouver
Cardoso MHM, Marcondes S, Lila S, De Nucci G, Turko IV, Murad F, Antunes E. A novel effect for annexin 1-derived peptide AC2-26: reduction of allergic inflammation in the rat. Resumos. 2005 ;[citado 2024 abr. 19 ] - Presence of nitric oxide synthase inhibitor activity in rat pleural exsudates
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