Morphological and proliferative analysis of the healing tissue in human alveolar sockets (2005)
- USP affiliated authors: ROMITO, GIUSEPPE ALEXANDRE - FO ; PUSTIGLIONI, FRANCISCO EMILIO - FO ; MARQUES, MARCIA MARTINS - FO
- Unidade: FO
- Subjects: REPARO ÓSSEO; REGENERAÇÃO ÓSSEA; IMUNOHISTOQUÍMICA; MICROSCOPIA ELETRÔNICA
- Language: Português
- Abstract: Healing tissues of extraction sockets have been used, as autografts, for the treatment of periodontal bony defects. These tissues have proved to be more effective in inducing bane formation than mature bane. However, there are limited data regarding the nature and proliferative activity of its cells. The aim of this pilot study was to analyze the nature and the proliferative activity of cells present in newly formed tissue from human extraction sockets, covered or not 1 by an e-PTFE membrane. The healing tissue of 6 pairs from human alveolar sockets covered or not by an e-PTFE membrane, collected 4 weeks after tooth extraction was analyzed. The specimens were observed using light and transmission electron microscopy (TEM). The immunohistochemical characterization of the tissues included type I collagen, osteonectin and bane sialoprotein detection. The proliferation rates ofthe tissues were obta1ned using PCNA labeling. Cells and extracellular matrix were labeled for type I collagen, osteonectin and bane sialoprotein, in both groups. PCNA antibodies revealed significant higher proliferation rates in the coronal areas than in the apical areas of the tis sues, independent of which group they belonged to. TEM showed cells containing a Golgi apparatus, rough endoplasmic reticulum and mitochondria indicative of secretory cells, in both groups. In the apical area ofthe test and contraI groups, the extracellular matrix exhibited more bundles of collagen fibrils than inthe coronal area. The cells of healing tissue of dental sockets are osteoblastic in nature. Additionally, they present higher proliferating rates in the coronal areas, independent of the use of the e-PTFE membrane
ABNTPENTEADO, Renata; ROMITO, Giuseppe Alexandre; PUSTIGLIONI, Francisco Emílio; MARQUES, Márcia Martins. Morphological and proliferative analysis of the healing tissue in human alveolar sockets. Brazilian Journal of Oral Sciences, Piracicaba, v. 4, n. Ja/Mar. 2005, p. 664-669, 2005.
APAPenteado, R., Romito, G. A., Pustiglioni, F. E., & Marques, M. M. (2005). Morphological and proliferative analysis of the healing tissue in human alveolar sockets. Brazilian Journal of Oral Sciences, 4( Ja/Mar. 2005), 664-669.
NLMPenteado R, Romito GA, Pustiglioni FE, Marques MM. Morphological and proliferative analysis of the healing tissue in human alveolar sockets. Brazilian Journal of Oral Sciences. 2005 ; 4( Ja/Mar. 2005): 664-669.
VancouverPenteado R, Romito GA, Pustiglioni FE, Marques MM. Morphological and proliferative analysis of the healing tissue in human alveolar sockets. Brazilian Journal of Oral Sciences. 2005 ; 4( Ja/Mar. 2005): 664-669.
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