Mandibular propulsive appliance modulates collagen- and laminin-binding integrins distribution in the rat condylar cartilage (2004)
- Authors:
- USP affiliated authors: KIMURA, EDNA TERUKO - ICB ; SANTOS, MARINILCE FAGUNDES DOS - ICB
- Unidade: ICB
- Assunto: HISTOLOGIA
- Language: Inglês
- Abstract: Objectives: we have shown that a propulsive mandibular appliance stimulates cell proliferation in the rat condylar cartilage, through an unknown mechanism. Our hypothesis is that integrins act as mechanoreceptors in this pathway, and the effects of such an appliance on the distribution of integrin subunits ?1 and ?2 in the condyle were studied. Methods and results: Wistar 28 days-old male rats used the appliance daily for 3, 5, 7, 9, 11, 15, 20, 30 and 35 days. Control (C) and experimental (E) groups were sacrificed at the matched age. Sagital sections of decalcified and Paraplast-embedded condyles were submitted to immunohistochemistry using the avidin-biotin-peroxidase technique. In control animals 'alfa'1 and 'alfa'2 were present at all ages, mostly in the hypertrophic layer. In the proliferative compartment, ?1 labeling peaked from C5 to C11, while ?2 labeling was more evident from C9 to C20. Although an increase in ?1 expression was observed at E9, this expression was much more pronounced than in control animals in the proliferative layers from E20 to E30. Similar results were observed for ?2 in the proliferative compartment, with an increase from E15 to E30. Conclusion: the modulation of 'alfa'1 and 'alfa'2-containing integrins distribution in the condyle by a propulsor appliance suggests that their function might contribute to mechanotransduction in chondrocytes
- Imprenta:
- Source:
- Título: Abstracts
- Conference titles: Congress of the Brazilian Society for Cell Biology
-
ABNT
MARQUES, Mara Rubia et al. Mandibular propulsive appliance modulates collagen- and laminin-binding integrins distribution in the rat condylar cartilage. 2004, Anais.. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2004. . Acesso em: 06 nov. 2024. -
APA
Marques, M. R., Hajjar, D., Kimura, E. T., & Santos, M. F. dos. (2004). Mandibular propulsive appliance modulates collagen- and laminin-binding integrins distribution in the rat condylar cartilage. In Abstracts. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Marques MR, Hajjar D, Kimura ET, Santos MF dos. Mandibular propulsive appliance modulates collagen- and laminin-binding integrins distribution in the rat condylar cartilage. Abstracts. 2004 ;[citado 2024 nov. 06 ] -
Vancouver
Marques MR, Hajjar D, Kimura ET, Santos MF dos. Mandibular propulsive appliance modulates collagen- and laminin-binding integrins distribution in the rat condylar cartilage. Abstracts. 2004 ;[citado 2024 nov. 06 ] - A mandibular propulsive appliance modulates collagen-binding integrins distribution in the young rat condylar cartilage
- Mandibular propulsive appliancefor rats: an experimental model for functional orthopedics
- Efeitos de um aparelho ortopédico funcional sobre a expressão de IGF-I e IGF-II na cartilagem condilar de ratos jovens
- Mandibular repositioning modulates IGFBP-3, -4, -5 and -6 expression in the mandibular condylar cartilage of young rats
- Aparelho propulsor da mandíbula aumenta a expressão de integrinas A2 e A5 na cartilagem condilar de ratos jovens
- Mudança da postura da mandíbula altera a expressão das IGFBP3, 4, 5 e 6 na cartilagem condilar de ratos
- MiRNA-146b-5p upregulates migration and invasion of different papillary thyroid carcinoma cells
- Propulsive appliance stimulates the synthesis of insulin-like growth factors I and II in the mandibular condylar cartilage of young rats
- Aparelho propulsor da mandíbula aumenta a expressão de integrinas A2 e A5 na cartilagem condilar de ratos jovens
- Aparelho propulsor mandibular para ratos: modelo experimental para ortopedia funcional
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
