The thyroid hormone receptor betaspecific agonist GC-1 selectively affects the bone development of hypothyroid rats independently of the GH/IGF-I axis (2004)
- Authors:
- USP affiliated authors: MORISCOT, ANSELMO SIGARI - ICB ; ZORN, TELMA MARIA TENORIO - ICB
- Unidade: ICB
- Assunto: HISTOLOGIA
- Language: Inglês
- Abstract: We studied the effects of the TR?-selective thyromimetic GC-1 on bone development. 21 day-old hypothyroid rats (Hypo) were treated for five weeks with 0.3µg/100g BW/day of T3 (1xT3), 5xT3, or equimolar doses of GC-1. Hypothyroidism impaired growth and BMD gain, delayed ossification, decreased bone metabolism, reduced the number of hypertrophic chondrocytes [HC; 72% vs. euthyroid, p<0.001] and resulted in disorganized of growth plate (GP) chondrocytes. Serum IGF-I was 67% reduced vs. euthyroid (p<0.001) and the expression of IGF-I protein and collagen II and X mRNAs were undetectable in the GP of Hypo. T3 completely or partially normalized these parameters. GC-1 did not influence serum concentrations or GP expression of IGF-I, failed to organize the GP, and barely affected growth. Nevertheless, GC-1 induced ossification, HC differentiation and collagen II and X mRNA expression and increased GP thickness to euthyroid values. GC-1 group had higher BMD gain than Hypo (p<0.05). These changes were associated with increased trabecular volume (48%, p<0.01), mineralization rate (2.3-fold, p<0.05), mineralizing surface (4.3-fold, p<0.01) and bone formation rate (10-fold, p<0.01). These findings suggest that TR? mediates some essential actions of T3 on bone development independently of GH/IGF-I signaling
- Imprenta:
- Source:
- Título: Abstracts
- Conference titles: Congress of the Brazilian Society for Cell Biology
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ABNT
FREITAS, F. R. S. et al. The thyroid hormone receptor betaspecific agonist GC-1 selectively affects the bone development of hypothyroid rats independently of the GH/IGF-I axis. 2004, Anais.. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2004. . Acesso em: 31 dez. 2025. -
APA
Freitas, F. R. S., Capelo, L. P., O'Shea, P. J., Jorgetti, V., Moriscot, A. S., Scanlan, T. S., et al. (2004). The thyroid hormone receptor betaspecific agonist GC-1 selectively affects the bone development of hypothyroid rats independently of the GH/IGF-I axis. In Abstracts. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Freitas FRS, Capelo LP, O'Shea PJ, Jorgetti V, Moriscot AS, Scanlan TS, Williams GR, Zorn TMT, Gouveia CH. The thyroid hormone receptor betaspecific agonist GC-1 selectively affects the bone development of hypothyroid rats independently of the GH/IGF-I axis. Abstracts. 2004 ;[citado 2025 dez. 31 ] -
Vancouver
Freitas FRS, Capelo LP, O'Shea PJ, Jorgetti V, Moriscot AS, Scanlan TS, Williams GR, Zorn TMT, Gouveia CH. The thyroid hormone receptor betaspecific agonist GC-1 selectively affects the bone development of hypothyroid rats independently of the GH/IGF-I axis. Abstracts. 2004 ;[citado 2025 dez. 31 ] - The thyroid hormone receptor 'beta'-specific agonist GC-1 selectively affects the bone development of hypothyroid rats
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