Expression of TGF'beta' and receptors in gastric mucosa of suckling rats: effects of hydrocortisone and dietary manipulation (2004)
- Authors:
- USP affiliated authors: ALVARES, ELIANA PARISI - ICB ; GAMA, PATRICIA - ICB
- Unidade: ICB
- Assunto: HISTOLOGIA
- Language: Inglês
- Abstract: Cell proliferation in gastric epithelium may be inhibited during postnatal development under different conditions as dietary manipulation and glucocorticoid treatment. The transforming growth factor beta (TGF?) can mediate these inhibitory responses, our aim was to evaluate the immunistaining for TGF?1, 2, 3 and recptors T?RI and T?RII in the gastric mucosa of 18-day-old pups using the early weaning model for diet manipulation and hydrocortisone treatment for hormonal induction. Rats were subjected to early weaning on the 15th day, to fasting on the 17th and sacrificed at 18 days. For hormonal treatment 18-day-old pups were injected i.p. with hydrocortisone (Sigma, 50 mg/kg) and sacrificed after 0, 1 and 3 hours. The stomachs were collected and processed for immunohistochemistry. Early weaning followed by fasting increased the number of TGF?3 and T?RI immunolabelled cells (p<0,05). After 3 hs of hydrocortisone treatment there was an increase in TGF?1 immunostaining (p<0,05) and a decrease of TGF?2 labelled cells (p<0,05). We can suggest that the upregulation of specific TGF? isoforms in the gastric epithelium after abrupt dietary change or hydrocortisone treatment, may be correlated to the inhibition of cell proliferation in the stomach during development
- Imprenta:
- Source:
- Título: Abstracts
- Conference titles: Congress of the Brazilian Society for Cell Biology
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ABNT
OGIAS, Daniela et al. Expression of TGF'beta' and receptors in gastric mucosa of suckling rats: effects of hydrocortisone and dietary manipulation. 2004, Anais.. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2004. . Acesso em: 09 jan. 2026. -
APA
Ogias, D., Bittencourt, B., Sá, E. R. A., Osaki, L. H., Nishitokukado, I., Alvares, E. P., & Gama, P. (2004). Expression of TGF'beta' and receptors in gastric mucosa of suckling rats: effects of hydrocortisone and dietary manipulation. In Abstracts. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Ogias D, Bittencourt B, Sá ERA, Osaki LH, Nishitokukado I, Alvares EP, Gama P. Expression of TGF'beta' and receptors in gastric mucosa of suckling rats: effects of hydrocortisone and dietary manipulation. Abstracts. 2004 ;[citado 2026 jan. 09 ] -
Vancouver
Ogias D, Bittencourt B, Sá ERA, Osaki LH, Nishitokukado I, Alvares EP, Gama P. Expression of TGF'beta' and receptors in gastric mucosa of suckling rats: effects of hydrocortisone and dietary manipulation. Abstracts. 2004 ;[citado 2026 jan. 09 ] - Efeito diferencial do jejum dos níveis de corticosterona em filhotes e ratos adultos:: consequências para o eptélio gástrico
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- Efeitos da desnutrição protéica materna na proliferação celular e expressão de fatores de crescimento no epitélio gatrintestinal de ratos
- Cell proliferation in the gastric epithelium under long-term corticosterone treatment
- Differential expression of transforming growth factor beta in the stomach of rats during development
- Cell proliferation and differentiation in the intestinal epithelium of weanling rats submitted to protein restriction during development
- TGFß role on the gastric epithelium: from sigmaling to cell cycle control
- Differential effects of fasting on corticosterone levels in suckling and adult rats: consequences to the gastric epithelium
- Influence of fasting on cell cycle proteins behavior in the gastric epithelium of pups and adult rats
- TGFalpha and EGFR are involved in gastric cell proliferation stimulated by early weaning through the activation of MAPK and SRC signaling pathways
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