Decidualization in rodents. the role of the small leucin-rich proteoglycans in the collagen fibrillogenesis (2004)
- Authors:
- Autor USP: ZORN, TELMA MARIA TENORIO - ICB
- Unidade: ICB
- Assunto: HISTOLOGIA
- Language: Inglês
- Abstract: Embryo implantation and development demands a complex sequence of cellular and molecular modifications in the uterus. Preceding the implantation, a wave of cell proliferation occurs in the endometrium followed by a transdifferentiation of endometrial fibroblasts into decidual cells. These new cells form a new temporary uterine structure called decidua, which plays essential role in maintaining normal pregnancies and proper embryo development. Decidualization is characterized by an extensive remodeling of the endometrial stroma including synthesis and degradation of extracellular molecules and a surge of very thick collagen fibrils in the decidualized areas of the endometrium. Studies performed in our laboratory and in another have shown differences between the preimplantation and post-implantation molecular profiles of the endometrial extracellular matrix. This finding suggests that remodeling is probably necessary for embryo implantation and development. Our immunocytochemical studies showed that the expression and distribution of SLRPs in the uterus of pregnant mice varies in different regions of theuterus and along the pregnancy. Before the embryo implantation the proteoglycans decorin and lumican where abundant in the endometrium. Curiously, following embryo implantation, the quantities of these molecules in the endometrium decrease currently with the appearance of very thick collagen fibrils. Contrary, biglican was highly expressed in thedecidualized endometrium and was associated with thick collagen fibrills. These results strongly indicate that biglycan plays a role in collagen fibrilogenesis and probably participate in the determination of collagen fibril thickness in the mouse decidua confirming the role of small richleucin proteoglycans (SRLPs) as important regulators of collagen fibril growth. ) They also indicate that morphological and molecular changes observed during the pre-implantation period, together with the redifferentiation of endometrial fibroblasts into decidual cells, comprise a new selective genetic program characterized by sequential and coordinate down and up regulation of various proteoglycans and glycosaminoglycans
- Imprenta:
- Source:
- Título: Abstracts
- Conference titles: Congress of the Brazilian Society for Cell Biology
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ABNT
SAN MARTIN, S. e ZORN, Telma Maria Tenório. Decidualization in rodents. the role of the small leucin-rich proteoglycans in the collagen fibrillogenesis. 2004, Anais.. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2004. . Acesso em: 03 mar. 2026. -
APA
San Martin, S., & Zorn, T. M. T. (2004). Decidualization in rodents. the role of the small leucin-rich proteoglycans in the collagen fibrillogenesis. In Abstracts. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
San Martin S, Zorn TMT. Decidualization in rodents. the role of the small leucin-rich proteoglycans in the collagen fibrillogenesis. Abstracts. 2004 ;[citado 2026 mar. 03 ] -
Vancouver
San Martin S, Zorn TMT. Decidualization in rodents. the role of the small leucin-rich proteoglycans in the collagen fibrillogenesis. Abstracts. 2004 ;[citado 2026 mar. 03 ] - Mapping of estradiol binding sites through receptor micro-autoradiography in the endometrial stroma of early pregnant mice
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