Artigo de periodico

Functional role, cellular source, and tissue distribution of rat elastase-2, an angiotensin II-forming enzyme (2003)

• Authors:
  • Santos, Carlos Ferreira dos
  • Caprio, Marcos Antonio V.
  • Oliveira, Eduardo Brandt de
  • Salgado, Maria Cristina de Oliveira
  • Schippers, Daniela Nicole
  • Munzenmaier, Diane H.
  • Greene, Andrew Seth
• Autor USP: SANTOS, CARLOS FERREIRA DOS - FOB
• Unidade: FOB
• DOI: 10.1152/ajpheart.00818.2002
• Assunto: ENDOTÉLIO
• Language: Inglês
• Abstract: We recently described a chvmostatin-sensitive elastase-2 as the major angiotensin (ANC I1-forming enzyme in the perfusate of the rat mesenteric arterial bed (MAB) with the same cDNA sequence as rat pancreatic elastase-2, The role of this enzyme in generating ANG 11 was examined in the rat isolated and perfused MAB. The vasoconstrictor effect elicited by ANG I and the renin substrate tetradecapeptide was only partially inhibited by captopril but abolished by the combination of captopril and chymostatin or N-acetyl-Ala-Ala-Pro-Leu-chrloromethylketone (Ac-AAPL-CK; inhibitor originally developed for human elastase-2 ). The effect induced by ('Pro POT.11', D-'Alan POT. 12)-ANG I, an ANG I-converting enzyme (ACE)-resistant biologically inactive precursor of ANG II, was blocked by chvmostatin or Ac-AAPL-CK. It was also demonstrated that cultured rat mesenteric endothelial cells synthesize elastase-2 and that mRNA for this enzyme can be detected in differentt rat tissues such as the pancreas, MAB, lung, heart, kidney. liver, and spleen. In conclusion, the demonstration of a functional alternative pathway to ACE for ANG II generation in the rat MAR and the fact that cultured MAB endothelial cells are capable of producing and secreting elastase-2 represent strong evidence of a physiological role for this enzyme in the rat vasculature
• Imprenta:
  • Publisher place: Bethesda
  • Date published: 2003
• Source:
  • Título: American Journal Physiology Heart and Circulatory Physiology
  • ISSN: 0363-6135
  • Volume/Número/Paginação/Ano: v. 285, p. H775-H783. Aug. 2003

Informações sobre o DOI: 10.1152/ajpheart.00818.2002 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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How to cite

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• ABNT

  SANTOS, Carlos Ferreira dos et al. Functional role, cellular source, and tissue distribution of rat elastase-2, an angiotensin II-forming enzyme. American Journal Physiology Heart and Circulatory Physiology, v. 285, p. H775-H783. Aug. 2003, 2003Tradução . . Disponível em: https://doi.org/10.1152/ajpheart.00818.2002. Acesso em: 19 out. 2024.

• APA

  Santos, C. F. dos, Caprio, M. A. V., Oliveira, E. B. de, Salgado, M. C. de O., Schippers, D. N., Munzenmaier, D. H., & Greene, A. S. (2003). Functional role, cellular source, and tissue distribution of rat elastase-2, an angiotensin II-forming enzyme. American Journal Physiology Heart and Circulatory Physiology, 285, H775-H783. Aug. 2003. doi:10.1152/ajpheart.00818.2002

• NLM

  Santos CF dos, Caprio MAV, Oliveira EB de, Salgado MC de O, Schippers DN, Munzenmaier DH, Greene AS. Functional role, cellular source, and tissue distribution of rat elastase-2, an angiotensin II-forming enzyme [Internet]. American Journal Physiology Heart and Circulatory Physiology. 2003 ; 285 H775-H783. Aug. 2003.[citado 2024 out. 19 ] Available from: https://doi.org/10.1152/ajpheart.00818.2002

• Vancouver

  Santos CF dos, Caprio MAV, Oliveira EB de, Salgado MC de O, Schippers DN, Munzenmaier DH, Greene AS. Functional role, cellular source, and tissue distribution of rat elastase-2, an angiotensin II-forming enzyme [Internet]. American Journal Physiology Heart and Circulatory Physiology. 2003 ; 285 H775-H783. Aug. 2003.[citado 2024 out. 19 ] Available from: https://doi.org/10.1152/ajpheart.00818.2002

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