Endogenous angiotensin modulate hindlimb resistance reflex control in spontaneously hypertensive and normotensive rats (2004)
- Authors:
- Autor USP: MICHELINI, LISETE COMPAGNO - ICB
- Unidade: ICB
- Assunto: FISIOLOGIA
- Language: Português
- Abstract: Objetivo: We sought to investigate the effects of chronic AT1 receptors blockade on reflex control of hind limb resistance in hypertensive and normotensive animals. Métodos e Resultados: Male SHR and WKY, aged 3 month and treated orally with vehicle (VEH=1ml/kg/day) or losartan (LOS=10 mg/kg/day) during 5 days, were chronically instrumented (day 3) with arterial/ venous catheters and iliac flow probe (Transonic). Arterial pressure (AP), heart hate (HR) and hindlimb blood flow (HLF) were recorded (and HL resistance calculated, HLR=MAP/HLF) in conscious freely moving rats on day 5. Reflex control of HLR was determined during loading/unloading of baroreceptors (graded doses of phenylephrine/sodium nitroprusside i.v).In both groups LOS reduced MAP (~13%) by reducing basal HLR (SHRLOS=67.0+-5.0 and WKYLOS=58.8+-10.7 mmHg/ml/min/g, -35% and -32% vs. respective VEH-treated groups) without changing HR and HLF levels. LOS caused leftward and downward displacement of HLR x MAP function curves. Conclusões: Endogenous angiotensin II, besides the tonic control of HLR and pressure in hypertensive and normotensive subjects, is also important to maintain both the reflex sensitivity and the high operational range for reflex control of skeletal muscle resistance. In addition data show that angiotensin II modulates (via AT1 receptors) not only reflex-induced vasocontriction, but also reflex-induced vasodilation during baroreceptors loading.
- Imprenta:
- Publisher place: Águas de Lindóia
- Date published: 2004
- Source:
- Título do periódico: Resumos
- Conference titles: Federação de Sociedades de Biologia Experimental, FeSBE
-
ABNT
DAL-CÓL, G. L. C. e BELTRÁN, G. A. R. e MICHELINI, Lisete Compagno. Endogenous angiotensin modulate hindlimb resistance reflex control in spontaneously hypertensive and normotensive rats. 2004, Anais.. Águas de Lindóia: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2004. . Acesso em: 19 set. 2024. -
APA
Dal-Cól, G. L. C., Beltrán, G. A. R., & Michelini, L. C. (2004). Endogenous angiotensin modulate hindlimb resistance reflex control in spontaneously hypertensive and normotensive rats. In Resumos. Águas de Lindóia: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Dal-Cól GLC, Beltrán GAR, Michelini LC. Endogenous angiotensin modulate hindlimb resistance reflex control in spontaneously hypertensive and normotensive rats. Resumos. 2004 ;[citado 2024 set. 19 ] -
Vancouver
Dal-Cól GLC, Beltrán GAR, Michelini LC. Endogenous angiotensin modulate hindlimb resistance reflex control in spontaneously hypertensive and normotensive rats. Resumos. 2004 ;[citado 2024 set. 19 ] - Participação de via simpática nitrérgica na mediação da vasodilatação reflexa do trem posterior
- Oxytocinergic regulation of cardiovascular function; studies in oxytocin deficient mice
- Angiotensin II contributes to isoproterenol-induced cardiomyocyte hypertrophy in normotensive mice
- Regulação neuroendócrina do sistema cardiovascular
- Exercise training differentially affects intrinsic excitability of autonomic and neuroendocrine neurons in the hypothalamic paraventricular nucleus
- Hypertension and AT1 blockade affect AT1a and angiotensinogen mRNA messages in brain areas
- Hypertension and training affect noradrenergic and gabaergic innervation of the hypothalamic paraventricular nucleus
- Treinamento físico induz respostas adaptativas na circulação da musculatura esquelética como um potencial mecanismo anti-hipertensivo
- Efeito da hipertensão e bloqueio do receptor AT1 sobre a expressão do RNAM para AT1A e angiotensinogênio no tronco cerebral
- Reflexo pressorreceptor durante o desenvolvimento de hipertensao arterial aguda
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
