5'-Nucleotidase activity is altered by hypo-and hyperthyroidism in platelets from adult rats (2004)
- Authors:
- Autor USP: CHAVES, MARIA LUIZA MORAIS BARRETO DE - ICB
- Unidade: ICB
- Assunto: ANATOMIA
- Language: Português
- Abstract: Objetivo: Thyroid disorders are associated to a number of vascular diseases that involve processes such as platelet aggregation and vascular tone control. Since these processes can also be affected by ATP, ADP and adenosine levels, we investigated the hydrolysis of these nucleotides in platelets from hyper-, hypo-, and hypothyroid with hormonal replacement rats. Métodos e Resultados: Methods and results: Hyperthyroidism was induced in adult male Wistar rats by daily injections of L-thyroxine (T4) 25 µg/ 100 g body weight, for 14 days. Hypothyroidism was induced by thyroidectomy and methimazole (0.05%) added to their drinking water for 14 days. In the hormonal replacement, hypothyroid rats were injected with T4 (5 µg/ 100 g body weight, i.p) for 5 days. The Pi released was measured by method of Chan et al (Anal. Biochem., 157: 375-80, 1986) and the protein concentration was determined using the Bradford (Anal. Biochem., 72: 218-254, 1976). The AMP hydrolysis was increased 49% in hyperthyroid rats and decreased 50% in response to hypothyroidism, but the ATP and ADP hydrolysis was not altered in this preparation. Besides, the T4 replacement reverted the inhibition of the AMP hydrolysis observed in hypothyroid rats.Conclusões: Conclusion: Our findings indicate that the thyroid disorders affects the 5'-nucleotidase activity and consequently the adenosine levels of a reversible manner in platelet fraction. Since, adenosine is able to inhibit the platelet aggregation and actsas a potent vasodilator, these results can contribute to a better comprehension of the vascular symptoms described in thyroid disorders
- Imprenta:
- Publisher: Federação de Sociedades de Biologia Experimental
- Publisher place: Águas de Lindóia, São Paulo
- Date published: 2004
- Source:
- Título do periódico: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE
-
ABNT
BÖHMER, A. E. et al. 5'-Nucleotidase activity is altered by hypo-and hyperthyroidism in platelets from adult rats. 2004, Anais.. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental, 2004. . Acesso em: 24 abr. 2024. -
APA
Böhmer, A. E., Nejar Bruno, A., Klein Ricachenevsky, F., Pochmann, D., Barreto-Chaves, M. L. M., & Sarkis, J. J. F. (2004). 5'-Nucleotidase activity is altered by hypo-and hyperthyroidism in platelets from adult rats. In Resumos. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental. -
NLM
Böhmer AE, Nejar Bruno A, Klein Ricachenevsky F, Pochmann D, Barreto-Chaves MLM, Sarkis JJF. 5'-Nucleotidase activity is altered by hypo-and hyperthyroidism in platelets from adult rats. Resumos. 2004 ;[citado 2024 abr. 24 ] -
Vancouver
Böhmer AE, Nejar Bruno A, Klein Ricachenevsky F, Pochmann D, Barreto-Chaves MLM, Sarkis JJF. 5'-Nucleotidase activity is altered by hypo-and hyperthyroidism in platelets from adult rats. Resumos. 2004 ;[citado 2024 abr. 24 ] - Influence of thyroid hormone on the adenosine production in the cardiac tissue evaluated in subcellular fractions
- Cardiac angiotensin II type I and type II receptors are increased in rats submitted to experimental hypothyroidism
- A influência da disfunção barorreflexa e da variabilidade da pressão arterial no remodelamento cardíaco em ratos normotensos
- Modulação da via da AMPK pelo hormônio tiroideano em culturas de cardiomiócitos
- Effects of chronic treatment with L-thyroxin on learning and memory: a behavioral approach to animal models of hyperthyroidism
- Ativação dos receptores A1 de adenosina induz analgesia e reduz ansiedade em ratos adultos hipertireoideos
- Efeito in vitro da angiotensina II sobre a hidrólise extracelular dos nucleotídeos ATP, ADP e AMP por plaquetas de ratos
- The hyperthyroidism and the renin-angiotensin system on cardiac microcirculation
- Hormônio tiroideano é capaz de modular rapidamente a proteína quinase ativada por AMP (AMPK) em culturas de cardiomiócitos
- Influência do sistema renina-angiotensina no desenvolvimento da hipertrofia cardíaca induzida pelo Hormônio Tireoideano
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
