Abnormal slow potential generators in schizophrenia (2003)
- Authors:
- Autor USP: BALDO, MARCUS VINICIUS CHRYSOSTOMO - ICB
- Unidade: ICB
- Assunto: FISIOLOGIA
- Language: Português
- Abstract: Objetivo: The purpose of this study was to compare slow cortical electrical activity between healthy and schizophrenic individuals using 123-channel EEG and Current Density Reconstruction. Métodos e Resultados: 29 healthy subjects and 14 drug-free patients performed three visual paired-associate tasks (verbal, pictorial and spatial), in which first and second stimuli had onsets separated by a delay of 2.5 seconds. All subjects signed consent forms approved by the University Ethics Committee. We modeled the generators of the Slow Potentials (SPs) at their peak amplitude by Lp-norm minimization using individual MRIs to model the volume conductor and source. Activity in each architectonic area of Brodmann was scored with respect to individual maximum current by a percentile method. Resulting scores (in absolute numbers) by cortical area were treated as dependent variables and analyzed by multivariate analysis of variance with planned comparisons, to search for differences among levels.) Results showed a multifocal pattern of current density foci comprising the SP generators, including frontal and posterior cortices in all subjects. A few cortical areas, not exclusively frontal, were observed to significantly differ between groups. Moreover, changes in patients' frontal activity were not exclusively to lower scores or 'hipofrontality': overall effects (all tasks collapsed) included increased electrical activity in right area 10, left 38 and 47 bilaterally, anddecreased activity in right area 6 and left areas 39, 21 and 19. Some of those changes could be attributed to given task(s), whereas a few additional areas showed significantly altered activity only in particular tasks. Conclusões: We conclude that the present method, by preserving individual anatomical and functional information, indicates bidirectional patterns of altered electrical activity in specific cortical association areas in schizophrenia, which are not compatible with the exclusive 'hipofrontality' hypothesis. Our results are in agreement with the hypothesis of schizophrenia as a syndrome resulting from abnormalities in multiple encephalic foci
- Imprenta:
- Publisher: Federação de Sociedades de Biologia Experimental
- Publisher place: Curitiba, Paraná
- Date published: 2003
- Source:
- Título do periódico: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE
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ABNT
BASILE, L. F. H.; BALDO, Marcus Vinicius Chrysostomo; YACUBIAN, J.; CAMPI DE CASTRO, C.; GATTAZ, W. F. Abnormal slow potential generators in schizophrenia. Anais.. Curitiba, Paraná: Federação de Sociedades de Biologia Experimental, 2003. -
APA
Basile, L. F. H., Baldo, M. V. C., Yacubian, J., Campi de Castro, C., & Gattaz, W. F. (2003). Abnormal slow potential generators in schizophrenia. In Resumos. Curitiba, Paraná: Federação de Sociedades de Biologia Experimental. -
NLM
Basile LFH, Baldo MVC, Yacubian J, Campi de Castro C, Gattaz WF. Abnormal slow potential generators in schizophrenia. Resumos. 2003 ; -
Vancouver
Basile LFH, Baldo MVC, Yacubian J, Campi de Castro C, Gattaz WF. Abnormal slow potential generators in schizophrenia. Resumos. 2003 ; - A contribuição relativa de mecanismos atencionais e pré-atencionais na percepção de ordem temporal
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