Moderate treadmill running does not change the size of 6-ohda induced striatal dopamine nerve terminal disappearance but counteracts the local astroglial scars (2003)
- Authors:
- Autor USP: CHADI, GERSON - ICB
- Unidade: ICB
- Assunto: ANATOMIA
- Language: Português
- Abstract: Objetivo: Physical exercise influences brain trophism and plasticity. Moderate treadmill running triggers changes on the apomorphine-induced circling behaviour in the 6-hydroxydopamine (6-OHDA) model of Parkinsonism as well as on motor parameters detected by infrared motion sensor. In the present work we have investigated the effects of moderate treadmill running on degenerative events in the nigrostriatal system after striatal injection of 6-OHDA. Métodos e Resultados: Rats were submitted to 5 days per week session in the treadmill: 6m/min for 20 min (first week) and 12m/min for 30 min (second week); rats trained 12m/min for 45 min in the third week, a regime that was maintained after surgery. After 6 weeks, trained and sedentary rats were submitted to unilateral striatal injection of 6-OHDA or solvent. The rats were sacrificed at 21 days and 50 days after dopamine lesion.) After sacrifice, rat brains were processed for tyrosine hydroxylase, glial fibrillary acidic protein, OX-42 immunohistochemistry, markers for dopamine cells, astrocytes and microglia, respectively, and quantified using stereology. The volume of the striatal lesion and the microglia activation was not changed in the trained rats compared to the sedentary rats in the two time-points. However, the volume of the astroglial reaction was decreased by 39% (p<0.01, t test) in the striatum of the trained rats. Conclusões: The results indicate that moderate treadmill running does not protectstriatum from 6-OHDA induced dopamine nerve terminal disappearance but may regulate later changes in astroglial reaction
- Imprenta:
- Publisher: Federação de Sociedades de Biologia Experimental
- Publisher place: Curitiba, Paraná
- Date published: 2003
- Source:
- Título do periódico: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE
-
ABNT
HEINZ, G. et al. Moderate treadmill running does not change the size of 6-ohda induced striatal dopamine nerve terminal disappearance but counteracts the local astroglial scars. 2003, Anais.. Curitiba, Paraná: Federação de Sociedades de Biologia Experimental, 2003. . Acesso em: 29 mar. 2024. -
APA
Heinz, G., Saavedra, M., Canterucci Gomide, V., & Chadi, G. (2003). Moderate treadmill running does not change the size of 6-ohda induced striatal dopamine nerve terminal disappearance but counteracts the local astroglial scars. In Resumos. Curitiba, Paraná: Federação de Sociedades de Biologia Experimental. -
NLM
Heinz G, Saavedra M, Canterucci Gomide V, Chadi G. Moderate treadmill running does not change the size of 6-ohda induced striatal dopamine nerve terminal disappearance but counteracts the local astroglial scars. Resumos. 2003 ;[citado 2024 mar. 29 ] -
Vancouver
Heinz G, Saavedra M, Canterucci Gomide V, Chadi G. Moderate treadmill running does not change the size of 6-ohda induced striatal dopamine nerve terminal disappearance but counteracts the local astroglial scars. Resumos. 2003 ;[citado 2024 mar. 29 ] - On the presence of the bfgf immunoreactivity in the spinal cord and dorsal root ganglia of the adult rat
- Distribution of the bfgf immunoreactivity in the spinal cord and dorsal root ganglia of the adult rat
- Spontaneous wheel running protects nigral striatal dopamine system from 6-hydroxydopamine neurotoxicity
- Maior crescimento de fibras nervosas na região da lesão medular completa tratada com enxerto de fragmentos de nervo ciático em presença do fator neurotrófico derivado de células gliais (gdnf). Estudo imunohistoquímico em ratos
- Efeitos da atividade física espontânea na arborização dendrítica de ratos submetidos à lesão estriatal isquêmica pela endotelina-1
- Immunohistochemistry combined to image analysis in the evaluation of the expression of glial and extracellular basic fibroblast growth factor in the corticospinal tract of the adult rat following a cervical mechanical lesion of the bulbar pyramid
- Stereological analysis of the astroglial and microglial reaction in the axotomized hypoglossal nucleus of the rat
- Neurochemical changes in the afferent and efferent auditory pathways ofthe adult rat following unilateral cochleotomy
- Evidence for a nuclear translocation of the basic fibroblast growth factor in vivo
- Basic fibroblast growth factor immunoreactivity is present in the reactive astrocytes but not reactive microglia in the rat forebrain after the kainate-induced seizures
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas