Effects of alcohol intake in the catecholaminergic neurotransmition in central cardiovascular area (2003)
- Authors:
- Autor USP: CHADI, GERSON - ICB
- Unidade: ICB
- Assunto: ANATOMIA
- Language: Português
- Abstract: Introduction: Young male Wistar rats were given a high protein liquid diet ad libitum containing 37.5% ethanol derived calories (6,7% v/v) for 12 hours, 7 days or 21 days. Control rats received isocaloric amounts of liquid diet, however with maltose-dextrin substituted for ethanol in the same periods described above. After treatment, the animals were sacrificed and their brains processed for immunohistochemistry of dopamine b-hidroxilase (DBH) and pheniletanolamine N-methyltransferase (PNMT) for the visualization of noradrenaline and adrenaline neurons. The binding parameters of a2-adrenergic receptors were also analysed. The nucleus of the solitary tract (NTS), ventrolateral medulla and hipothalamic paraventricular nucleus (PVN) were studied. Amygdala and piriform cortex were also analysed. The immunohistochemistry of DBH and PNMT was quantified by means of stereology. Quantitative receptor radioautography by means of inibition and saturation experiments and data of IC50, B0, KD and BMAX, was used for the analysis of a2-adrenoceptors.Results:The results showed that alcohol intake for 12 hours increased IC50 value in the NTS and amygdala. The alcohol exposure for 7 days increased B0 value in the PVN and amygdala, and the IC50 value in the piriform cortex. At this time DBH immunoreactivity was decreased in the A2 noradrenergic neurons of the NTS and PNMT immunoreactivity was increased in the C2 adrenergic neurons. Alcohol exposure for 21days increased the IC50 value in amygdala and piriform cortex, B0 in NPV as well as KD e BMAX values in amygdala, and KD in piriform cortex. The immunohistochemistry showed that alcohol exposure for 21 days increased adrenaline and noradrenaline immunoreactivity in catecholaminergic neurons of the NTS and ventrolateral medulla. Conclusion: These results suggest that alcohol may interfere with central control of blood pressure by changing catecholamine levels and the binding of a2-adrenergic receptors in the central cardiovascular areas
- Imprenta:
- Publisher: Comissão de Pesquisa do ICB/USP
- Publisher place: São Paulo
- Date published: 2003
- Source:
- Título: Resumos
- Conference titles: Congresso Instituto Ciências Biomédicas, IV
-
ABNT
SILVEIRA, Gilcélio Amaral e CHADI, Gerson e FIOR-CHADI, Débora Rejane. Effects of alcohol intake in the catecholaminergic neurotransmition in central cardiovascular area. 2003, Anais.. São Paulo: Comissão de Pesquisa do ICB/USP, 2003. . Acesso em: 19 out. 2024. -
APA
Silveira, G. A., Chadi, G., & Fior-Chadi, D. R. (2003). Effects of alcohol intake in the catecholaminergic neurotransmition in central cardiovascular area. In Resumos. São Paulo: Comissão de Pesquisa do ICB/USP. -
NLM
Silveira GA, Chadi G, Fior-Chadi DR. Effects of alcohol intake in the catecholaminergic neurotransmition in central cardiovascular area. Resumos. 2003 ;[citado 2024 out. 19 ] -
Vancouver
Silveira GA, Chadi G, Fior-Chadi DR. Effects of alcohol intake in the catecholaminergic neurotransmition in central cardiovascular area. Resumos. 2003 ;[citado 2024 out. 19 ] - On the presence of the bfgf immunoreactivity in the spinal cord and dorsal root ganglia of the adult rat
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