Regulation of insulin-induced Tyrosine-Phosphorylation of IRS-1, IR-2, and IRS-3, in adipose tissue of two distinct animal models of insulin resistance: aging and glucocorticoid excess in vivo (2002)
- Authors:
- Autor USP: CARVALHO, CARLA ROBERTA DE OLIVEIRA - ICB
- Unidade: ICB
- Assunto: FISIOLOGIA
- Language: Inglês
- Abstract: The insulin receptor substrates molecules, IRS-1, IRS-2, and IRS-3 are key mediators in insulin signaling in the adipose tissue. IRS-1 and IRS-2 are wide expressed and located mainly in the low density microsome fraction while IRS-3, specific of adipose tissue, is located mainly in the plasma membrane fraction. These tree substrates are mediators of insulin-induced PI3-kinase activation. Although the IRS-3-null mice showed no difference from wild-type in body weight, in blood glucose level, and in fasted and fed insulin levels, the regulation of IRS-3 in conditions that show insulin resistance are not known. In the present study, we examined the phosphorylation state of insulin receptor (IR), IRS-1/2 and IRS-3 in adipose tissue of aging rats as well as dexamethasone treated rats. In adipose tissue from 12-month-old rats, insulin-induced tyrosine phosphorylation in anti-phosphotyrosine immunoprecipitates were reduced to 65±9% for IR, to 50±8% for both IRS-1 and IRS-2, and to 78±2% for IRS-3 compared to 2-month-old controls rats. In a same fashion way, the 2-month-old dexamethasone treated rats had a reduction to 47±3% for IR, to 52±3% for both IRS-1 and IRS-2, and to 68±9% for IRS-3. These pattern of reduced insulin-induced tyrosine phosphorylation of IRS proteins in the adipose tissue of two models that exhibit hyperinsulinemia and obesity may have a role in the insulin resistance observed in these models
- Imprenta:
- Publisher: Comissão de Cultura e Extensão Universitária do ICB/USP
- Publisher place: São Paulo
- Date published: 2002
- Source:
- Título do periódico: Resumos
- Conference titles: Congresso Instituto Ciências Biomédicas, IV
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ABNT
CAPERUTO, Luciana C et al. Regulation of insulin-induced Tyrosine-Phosphorylation of IRS-1, IR-2, and IRS-3, in adipose tissue of two distinct animal models of insulin resistance: aging and glucocorticoid excess in vivo. 2002, Anais.. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP, 2002. . Acesso em: 24 abr. 2024. -
APA
Caperuto, L. C., Souza, L. C., Anhê, G. F., Ribeiro, L. M., Amanso, A. M., Campbell, C. S. G., et al. (2002). Regulation of insulin-induced Tyrosine-Phosphorylation of IRS-1, IR-2, and IRS-3, in adipose tissue of two distinct animal models of insulin resistance: aging and glucocorticoid excess in vivo. In Resumos. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP. -
NLM
Caperuto LC, Souza LC, Anhê GF, Ribeiro LM, Amanso AM, Campbell CSG, Medina M, Carvalho CR de O. Regulation of insulin-induced Tyrosine-Phosphorylation of IRS-1, IR-2, and IRS-3, in adipose tissue of two distinct animal models of insulin resistance: aging and glucocorticoid excess in vivo. Resumos. 2002 ;[citado 2024 abr. 24 ] -
Vancouver
Caperuto LC, Souza LC, Anhê GF, Ribeiro LM, Amanso AM, Campbell CSG, Medina M, Carvalho CR de O. Regulation of insulin-induced Tyrosine-Phosphorylation of IRS-1, IR-2, and IRS-3, in adipose tissue of two distinct animal models of insulin resistance: aging and glucocorticoid excess in vivo. Resumos. 2002 ;[citado 2024 abr. 24 ] - Evidence for a direct effect of captopril on early steps of insulin action in BC3H-1 myocytes
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