Suppressive effect of Ascaris suum extract on immune response to ovalbumil is independent of IFN-G and IL-12 (2002)
- Authors:
- Autor USP: MACEDO, MAHASTI SAHIHI DE - ICB
- Unidade: ICB
- Assunto: IMUNOLOGIA
- Language: Inglês
- Abstract: Ascaris suum extract (Asc) down-regulates the immune response to ovalbumin (OA) as well as preferentially stimulates a Th2 response to its own components, which is responsible for the suppression of the OA-specific Th1 response. IL-4 plus IL-10-specific monoclonal antibody treatment of mice before immunization with OA + Asc abolishes this suppression. The immunosuppressive activity of Asc is due to high MW proteins (PI) that are obtained by gel filtration chromatography. Although PI stimulates IL-4 and IL-10 secretion, IgE and anaphylactic IgG1 antibodies against PI are only obtained in IL-12 or IFN-g-/-deprived mice. In this work, we investigated the role of IL-12 and IFN-g in the suppression exerted by PI on an unrelated immune response. IFN-g- or IL-12-deficient (IL-12-/- / IFN-g-/-) or wild-type mice were immunized with OA or OA + PI in complete Freund's adjuvant and challenged in the hind footpad with aggregated OA after 8 days. Immediate and delayed-type-hypersensitivity (DTH) reactions and antibody were compared in these mice. Hypersensitivity reactions and OA-specific IgE, IgG1 and IgG2a remained dampened in IL-12-/- or IFN-g-/- OA + PI-immunized mice. In agreement with previous results obtained in our lab, a diminished DTH reaction was obtained in IL-12-/-, OA-immunized mice, in contrast to an increased reaction in IFN-g-/- mice. These results suggest that IL-12 and IFN-g do not participate in the down-regulation of anti-OAresponse induced by PI, ever though they act differently in OA-specific DHT
- Imprenta:
- Publisher: Comissão de Cultura e Extensão Universitária do ICB/USP
- Publisher place: São Paulo
- Date published: 2002
- Source:
- Título: Resumos
- Conference titles: Congresso Instituto Ciências Biomédicas, IV
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ABNT
SOUZA, V M O e JACYSY, J F e MACEDO, Mahasti Sahihi de. Suppressive effect of Ascaris suum extract on immune response to ovalbumil is independent of IFN-G and IL-12. 2002, Anais.. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP, 2002. . Acesso em: 11 mar. 2026. -
APA
Souza, V. M. O., Jacysy, J. F., & Macedo, M. S. de. (2002). Suppressive effect of Ascaris suum extract on immune response to ovalbumil is independent of IFN-G and IL-12. In Resumos. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP. -
NLM
Souza VMO, Jacysy JF, Macedo MS de. Suppressive effect of Ascaris suum extract on immune response to ovalbumil is independent of IFN-G and IL-12. Resumos. 2002 ;[citado 2026 mar. 11 ] -
Vancouver
Souza VMO, Jacysy JF, Macedo MS de. Suppressive effect of Ascaris suum extract on immune response to ovalbumil is independent of IFN-G and IL-12. Resumos. 2002 ;[citado 2026 mar. 11 ] - Supressao da resposta imune celular de camundongos pela fracao pi do extrato de ascaris suum
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