Characterization of the GGIS encoding geranylgeranyl-isoprenyl synthetase responsable for the isoprenic chain biosynthesis of coenzyme Q of plasmodium falciparum (2002)
- Authors:
- USP affiliated authors: WUNDERLICH, GERHARD - ICB ; KIMURA, EDNA TERUKO - ICB ; KATZIN, ALEJANDRO MIGUEL - ICB
- Unidade: ICB
- Subjects: HISTOLOGIA; PARASITOLOGIA
- Language: Inglês
- Abstract: Plasmodium falciparum is more lethal than the other three species of human malaria. There is an urgent need to develop new therapeutic targets against malaria's parasites, because they are becoming resistant to the most of drugs currently in use in malaria therapeutics. The isoprenoid biosynthesis pathway of intraerythrocytic parasites has been studied and pointed as important target for the development of new antimalarial drugs. This pathway is responsible for the synthesis of prenylated proteins, dolichols and ubiquinones (or Coenzyme Q) in P. falciparum. All these products are derived from linear prenyl diphosphates, which are synthesized by sequential condensations of isopentenyl diphosphate (IPP) with allelic prenyl diphosphates. The condensation is catalysed by a family of enzymes known as prenyltransferases. The inhibition of these enzymes has been the focus of recent efforts to designing drugs. The gene that encodes a kind of prenyltransferases probable catalyses isoprenic chain elongation in the benzoquinone ring of Coenzyme Q - was isolated of P. falciparum. We can predict that such enzyme can be indicated as an interesting target for action of antimalarial drugs, for example, the terpenes. In this work we show the PCR amplification of the product GGIS in P. falciparum; the putative gene encondes the product of GGIS in Northern blot and RT-PCR assays in the different intraerytrocytic stages, we are been trying to express the recombinant protein and topurification they native version
- Imprenta:
- Publisher: Comissão de Cultura e Extensão Universitária do ICB/USP
- Publisher place: São Paulo
- Date published: 2002
- Source:
- Título: Resumos
- Conference titles: Congresso Instituto Ciências Biomédicas, IV
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ABNT
TONHOSOLO, R et al. Characterization of the GGIS encoding geranylgeranyl-isoprenyl synthetase responsable for the isoprenic chain biosynthesis of coenzyme Q of plasmodium falciparum. 2002, Anais.. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP, 2002. . Acesso em: 29 dez. 2025. -
APA
Tonhosolo, R., Wunderlich, G., Kimura, E. A., Peres, V. J., & Katzin, A. M. (2002). Characterization of the GGIS encoding geranylgeranyl-isoprenyl synthetase responsable for the isoprenic chain biosynthesis of coenzyme Q of plasmodium falciparum. In Resumos. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP. -
NLM
Tonhosolo R, Wunderlich G, Kimura EA, Peres VJ, Katzin AM. Characterization of the GGIS encoding geranylgeranyl-isoprenyl synthetase responsable for the isoprenic chain biosynthesis of coenzyme Q of plasmodium falciparum. Resumos. 2002 ;[citado 2025 dez. 29 ] -
Vancouver
Tonhosolo R, Wunderlich G, Kimura EA, Peres VJ, Katzin AM. Characterization of the GGIS encoding geranylgeranyl-isoprenyl synthetase responsable for the isoprenic chain biosynthesis of coenzyme Q of plasmodium falciparum. Resumos. 2002 ;[citado 2025 dez. 29 ] - Antimalarial activity terpenes
- Carotenoid biosynthesis in intraerythrocytic stages of Plasmodium falciparum
- Limonene arrests parasite development and inhibits isoprenylation of proteins in plasmodium falciparum
- Identification and characterization of the ge encoding geranylgeranyl synthesis (GGSI) responsable for the isoprenic chain biosynthesis of coenzime Q of P. falciparum
- Carotenoid biosynthesis in intraerythrocytic stages of Plasmodium
- Cloning and kinetic characterization of plasmodium falciparum polyprenyl diphosphate synthase - a possible new drug target
- Caracterização funcional da farnesil difosfato sintase e efeito de compostos bifosfonatos nos estágios intraeritrocitários de Plasmodium falciparum
- Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum
- Carotenoid biosynthesis in the intraerythrocytic stages of Plasmodium falciparum
- Inhibition of the proteolytic activity of the proteasome by terpenes in cultures of the Plasmodium falciparum
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