Involvement of a1 adenosine receptors on the bradycardia induced by exercise training (2001)
- Authors:
- Autor USP: NUCCI, GILBERTO DE - ICB
- Unidade: ICB
- Assunto: FARMACOLOGIA
- Language: Inglês
- Abstract: Objetivo: Objectives: The aim of this work was to evaluate the potency of CPA, an agonist of A1 adenosine receptors, in isolated right atria from treadmill trained rats. Métodos e Resultados: Methods and Results: Male wistar rats were exercised in a treadmill, five days a week, during 60 minutes each session for two weeks. The right atria were isolated and concentration-response curves to CPA were obtained. No changes were observed in body weight after two weeks of physical activity (261±7 g vs 249±4 g for sedentary and trained animals, respectively). Heart rate was significantly reduced in trained group (366±6 beats/min) as compared to sedentary animals (396±9 beats/min) while blood pressure values were not different (104±2; 102±4 mmHg for sedentary and running rats, respectively). Exercise training for two weeks did not modify the spontaneous beating rate (305±13 vs 275±9 beats/min for sedentary and trained animals, respectively). A 10-fold rightward shift of concentration-response curves to CPA was found in trained animals (7.90±0.12) as compared to sedentary animals (8.93±0.25) at pEC50 level. Conclusões: Conclusion: Exercise training in treadmill for two weeks induced a desensitization of negative chronotropic responses mediated by A1 receptors in rat isolated right atria
- Imprenta:
- Publisher: Federação de Sociedades de Biologia Experimental
- Publisher place: Caxambu
- Date published: 2001
- Source:
- Título: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental - FeSBE
-
ABNT
BRUSCHI MARINHO PRIVIERO, F et al. Involvement of a1 adenosine receptors on the bradycardia induced by exercise training. 2001, Anais.. Caxambu: Federação de Sociedades de Biologia Experimental, 2001. . Acesso em: 28 out. 2024. -
APA
Bruschi Marinho Priviero, F., Araujo Nogueira, T. C. D., Antunes, E., Zanesco, A., & De Nucci, G. (2001). Involvement of a1 adenosine receptors on the bradycardia induced by exercise training. In Resumos. Caxambu: Federação de Sociedades de Biologia Experimental. -
NLM
Bruschi Marinho Priviero F, Araujo Nogueira TCD, Antunes E, Zanesco A, De Nucci G. Involvement of a1 adenosine receptors on the bradycardia induced by exercise training. Resumos. 2001 ;[citado 2024 out. 28 ] -
Vancouver
Bruschi Marinho Priviero F, Araujo Nogueira TCD, Antunes E, Zanesco A, De Nucci G. Involvement of a1 adenosine receptors on the bradycardia induced by exercise training. Resumos. 2001 ;[citado 2024 out. 28 ] - Presence of nitric oxide synthase inhibitor activity in rat pleural exsudates
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