Type-1 interferons and innate resistance to Trypanosoma cruzi infection (2001)
- Authors:
- Autor USP: ABRAHAMSOHN, ISES DE ALMEIDA - ICB
- Unidade: ICB
- Assunto: IMUNOLOGIA
- Language: Inglês
- Abstract: Type I interferons are known for their antiviral activity and their production in viral infections. Objectives: We investigated type I IFN in murine Trypanosoma cruzi infection and their potential role in controlling parasitism, nitric oxide and cytokine production. Methods: Type I IFN production was measured by viral neutralization assay in the presence of anti-IFN-g ?mAb. Results: IFN-I production by infected mice was already detected 24 h after infection in peritoneal macrophages and at later times in the spleen. Resistant C57 BL/6 mice produced 4-10 fold higher levels of type I IFN than susceptible BALB/c or A/J strains. We next investigated the effect of treatment with neutralizing anti- IFN-I Ab or with purified IFN I on NO production by SC from infected mice. Neutralization of endogenously produced IFN-??? in SC cultures (days 3 and 8 of infection) and in infected peritoneal macrophage cultures reduced NO production by 40-50 %. Infection with T.cruzi of 129/Sv mice deprived of the genes coding for the IFN-??? receptor (IFN-??? R KO) resulted in 3-fold increased parasitemia levels in the acute phase as compared to infected wild type matched control mice; no differences in mortality rates were observed.In comparison with wild type controls, the production of NO by T.cruzi-infected peritoneal cell cultures from IFN-??? R KO mice was markedly reduced (80%). Conclusions: Taken together, the results indicate that endogenously produced IFN-I costimulatesNO synthesis by macrophages and contributes to the initial control of parasitism by innate immunity
- Imprenta:
- Publisher: Comissão de Cultura e Extensão Universitária do ICB/USP
- Publisher place: São Paulo
- Date published: 2001
- Source:
- Título do periódico: Resumos
- Conference titles: Congresso do Instituto de Ciências Biomédicas
-
ABNT
COSTA, V M A et al. Type-1 interferons and innate resistance to Trypanosoma cruzi infection. 2001, Anais.. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP, 2001. . Acesso em: 30 set. 2024. -
APA
Costa, V. M. A., Mendonça, R. Z., Gresser, I., & Abrahamsohn, I. de A. (2001). Type-1 interferons and innate resistance to Trypanosoma cruzi infection. In Resumos. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP. -
NLM
Costa VMA, Mendonça RZ, Gresser I, Abrahamsohn I de A. Type-1 interferons and innate resistance to Trypanosoma cruzi infection. Resumos. 2001 ;[citado 2024 set. 30 ] -
Vancouver
Costa VMA, Mendonça RZ, Gresser I, Abrahamsohn I de A. Type-1 interferons and innate resistance to Trypanosoma cruzi infection. Resumos. 2001 ;[citado 2024 set. 30 ] - Endogenously produced IL-10 and prostaglandins regulate peripheral blood mononuclear cells proliferation to Trypanosoma cruzi antigens
- Nitric oxide produced by macrophages and regulation of resistance to "Trypanosoma cruzi" at the initial phase of infection
- Egulation of Trypanosoma cruzi infection by type interferons
- Il-12 regulation of ifn-gama synthesis in the acute phase of trypanosoma cruzi infection
- IL-12 regulation of IFN-'gama' synthesis in the acute phase of Trypanosoma cruzi infection
- Prostaglandins mediate suppression of lymphoproliferation and cytokine synthesis during the early phase of Trypanosoma cruzi infection
- Il-12 enhances proliferation of peripheral blood mononuclear cells from chagasic patients to trypanosoma cruzi antigen
- Il-10 and ifn-gamma production by spleen cells in trypanosoma cruzi infected mice
- Bordetella pertussis and innate immune response: inhibition of NO production by murine BMDMO through TGF-ß arginase and TLR4
- Immature macrophages derived from mouse bone marrow produce large amounts of IL-12p40 after LPS stimulation
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