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Sex differences in the contribution of no and EDHF to endothelium-dependent vascular relaxation in doca-salt rats (2001)

• Authors:
  • Cobra, A L
  • Montezano, A C I
  • Leite, S M R
  • Carvalho, M H C
  • Passaglia, Rita de Cássia Aleixo Tostes
• USP affiliated authors: CARVALHO, MARIA HELENA CATELLI DE - ICB ; PASSAGLIA, RITA DE CASSIA ALEIXO TOSTES - ICB
• Unidade: ICB
• Assunto: FARMACOLOGIA
• Language: Inglês
• Abstract: INTRODUCTION: The endothelium plays a major role in vascular tone control by releasing relaxing factors (EDRFs), such as arachidonic acid metabolites (PGs), nitric oxide (NO) and the endothelium-derived hyperpolarizing factor (EDHF). DOCA-salt arteries exhibit impaired endothelium-dependent relaxation and sex differences in the endothelium modulation of vascular tone have been described. We tested whether the contribution of PGs, NO and EDHF to acetylcholine (ACh) vasodilatation is different in male and female DOCA-salt rats. METHODS: ACh (10-8M-10-3M) relaxation was evaluated in norepinephrine (NE 1-5x10-6M)-constricted mesenteric beds from DOCA-salt and control rats. RESULTS: 1)ACh vasodilatation was similarly impaired in male (63%±4) and female (62%±5, n=14) DOCA-salt vs. control (male 88%±1; female 85%±2, n=10). 2)ACh responses in vessels constricted with NE+KCl (25mM, to inhibit EDHF-mediated vasodilatation) were similarly decreased in control (male 45±5%; female 39±5%, n=9) and male DOCA-salt (43±8%, n=6) arteries, but to a less extent in female DOCA-salt (16±2%, n=12). 3)ACh responses in the presence of L-NAME (10-4M, a NOS inhibitor) were less inhibited in DOCA-salt (male 24±6%; female 17±3%, n=8) vs. control (male 56±8%; female 44±8%, n=8) arteries. 4)Indometacin (3?M, a cyclooxigenase inhibitor) reduced ACh vasodilatation in control (male 35±5%; female 42±5%, n=8) but not in DOCA-salt (male 7±9%; female 5±5%, n=5). CONCLUSION: 1)The NO componentin ACh response is greater in female compared to male DOCA-salt arteries, but similar in male and female control arteries 2)EDHF contribution to ACh vasodilatation is similar in male and female DOCA-salt and greater than in control rats. 3)PGs play a role in ACh vasodilatation in control, but not in DOCA-salt rats
• Imprenta:
  • Publisher: Comissão de Cultura e Extensão Universitária do ICB/USP
  • Publisher place: São Paulo
  • Date published: 2001
• Source:
  • Título do periódico: Resumos
• Conference titles: Congresso do Instituto de Ciências Biomédicas

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How to cite

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• ABNT

  COBRA, A L et al. Sex differences in the contribution of no and EDHF to endothelium-dependent vascular relaxation in doca-salt rats. 2001, Anais.. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP, 2001. . Acesso em: 23 abr. 2024.

• APA

  Cobra, A. L., Montezano, A. C. I., Leite, S. M. R., Carvalho, M. H. C., & Passaglia, R. de C. A. T. (2001). Sex differences in the contribution of no and EDHF to endothelium-dependent vascular relaxation in doca-salt rats. In Resumos. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP.

• NLM

  Cobra AL, Montezano ACI, Leite SMR, Carvalho MHC, Passaglia R de CAT. Sex differences in the contribution of no and EDHF to endothelium-dependent vascular relaxation in doca-salt rats. Resumos. 2001 ;[citado 2024 abr. 23 ]

• Vancouver

  Cobra AL, Montezano ACI, Leite SMR, Carvalho MHC, Passaglia R de CAT. Sex differences in the contribution of no and EDHF to endothelium-dependent vascular relaxation in doca-salt rats. Resumos. 2001 ;[citado 2024 abr. 23 ]

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