Respiratory infection, exposure to mouse allergen and breastfeeding: role in recurrent wheezing in early life (2009)
- Autores:
- Autores USP: ARRUDA, LUISA KARLA DE PAULA - FMRP ; CARDOSO, MARIA REGINA ALVES - FSP
- Unidades: FMRP; FSP
- Assuntos: ASMA; ENDOTOXINAS; HIPERSENSIBILIDADE; INFECÇÕES RESPIRATÓRIAS; RESPIRAÇÃO (FISIOPATOLOGIA)
- Idioma: Inglês
- Resumo: Background: Environmental factors may influence the development of allergen sensitization and asthma. The aim of this study was to evaluate the role of endotoxin and allergen exposure in early life as a risk factor for recurrent wheezing. Methods: One hundred and four infants from low-income families, at high risk of asthma, were enrolled at birth. Dust samples were collected from the bedding and bedroom floor within 6 months after birth. Recurrent wheezing was defined as 3 or more wheezing episodes in the past year. Endotoxin was determined by Limulus amebocyte lysate assay, and major indoor allergens were quantitated by ELISA in dust extracts. IgE antibodies were measured by ImmunoCAP at 30 months of age. Results: At 30 months, 51 of the 99 infants who completed the study (51.5 per cent) had recurrent wheezing. Respiratory infection was strongly associated with recurrent wheezing (OR 6.67, 95 per cent CI 1.96-22.72), whereas exclusive breastfeeding for at least 1 month was a protective factor (OR 0.09, 95 per cent CI 0.01-0.51). Exposure to high levels of mouse allergen was more frequent among non-recurrent wheezers, approaching significance (OR 0.12, 95 per cent CI 0.01-1.13; p = 0.064). None of the children were sensitized to mouse. Sensitization to mite was found in 26/90 (28.8 per cent) children, with no association with recurrent wheezing. Conclusion: Respiratory infection was strongly associated with recurrent wheezing in the first 30 months of life, inchildren at high risk of asthma, living in a socially deprived community in Brazil
- Imprenta:
- Fonte:
- Título do periódico: International Archives of Allergy and Immunology
- ISSN: 1018-2438
- Volume/Número/Paginação/Ano: v. 150, n. 2, p. 172-178, 2009
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ABNT
RULLO, V.E.V et al. Respiratory infection, exposure to mouse allergen and breastfeeding: role in recurrent wheezing in early life. International Archives of Allergy and Immunology, v. 150, n. 2, p. 172-178, 2009Tradução . . Acesso em: 19 abr. 2024. -
APA
Rullo, V. E. V., Arruda, L. K., Cardoso, M. R. A., Valente, V., Zampolo, A. S., Nobrega, F., et al. (2009). Respiratory infection, exposure to mouse allergen and breastfeeding: role in recurrent wheezing in early life. International Archives of Allergy and Immunology, 150( 2), 172-178. -
NLM
Rullo VEV, Arruda LK, Cardoso MRA, Valente V, Zampolo AS, Nobrega F, Naspitz CK, Solé D. Respiratory infection, exposure to mouse allergen and breastfeeding: role in recurrent wheezing in early life. International Archives of Allergy and Immunology. 2009 ; 150( 2): 172-178.[citado 2024 abr. 19 ] -
Vancouver
Rullo VEV, Arruda LK, Cardoso MRA, Valente V, Zampolo AS, Nobrega F, Naspitz CK, Solé D. Respiratory infection, exposure to mouse allergen and breastfeeding: role in recurrent wheezing in early life. International Archives of Allergy and Immunology. 2009 ; 150( 2): 172-178.[citado 2024 abr. 19 ] - Allergen and endotoxin exposure, infection, and breastfeeding in early life, and recurrent wheezing in children: 30-month follow-up of a cohort study
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