Cardiovascular, metabolic and hormonal responses to the progressive exercise performed to exhaustion in patients with type 2 diabetes treated with metformin or glyburide (2008)
- Authors:
- USP affiliated authors: SILVA, MAGDA APARECIDA RIBEIRO DA - FM ; FUKUI, ROSA TSUNECHIRO - FM ; WAJCHENBERG, BERNARDO LEO - FM ; ROCHA, DALVA MARREIRO - FM ; NEGRÃO, CARLOS EDUARDO - EEFE ; URSICH, MILENI JOSEFINA MARIA - FM
- Unidades: FM; EEFE
- DOI: 10.1111/j.1463-1326.2006.00690.x
- Subjects: SISTEMA CARDIOVASCULAR; METABOLISMO; OBESIDADE; DIABETES MELLITUS
- Language: Inglês
- Abstract: Objectives: To evaluate the effects of Metformin and Glyburide on cardiovascular, metabolic and hormonal parameters during progressive exercise performed to exhaustion in the post-prandial state in women with type 2 diabetes (T2DM). Design and Methods: Ten T2DM patients treated with Metformin (M group), 10 with Glyburide (G group) and 10 agepaired healthy subjects exercised on a bicycle ergometer up to exercise peak. Cardiovascular and blood metabolic and hormonal parameters were measured at times -60 min, 0 min, exercise end, and at 10 and 20 minutes of recovery phase. Thirty minutes before the exercise, a standard breakfast was provided to all participants. The diabetic patients took Metformin or Glyburide before or with meal. Results: Peak oxygen uptake (VO2) was lower in patients with diabetes. Plasma glucose levels remained unchanged, but were higher in both diabetic groups. Patients with diabetes also presented lower insulin levels after meals and higher glucagon levels at exercise peak than C group. Serum cortisol levels were higher in G than M group at exercise end and recovery phase. Lactate levels were higher in M than G group at fasting and in C group at exercise peak. Nor epinephrine, GH and FFA responses were similar in all 3 groups. Conclusion: Progressive exercise performed to exhaustion, in the post-prandial state did not worsen glucose control during and after exercise. The administration of the usual dose of Glyburide or Metformin toT2DM patients did not influence the cardiovascular, metabolic and hormonal response to exercise
- Imprenta:
- Source:
- Título do periódico: Diabetes, obesity & metabolism
- Volume/Número/Paginação/Ano: v. 10, n. 3, p. 238-245, mar. 2008
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
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ABNT
CUNHA, M.C. et al. Cardiovascular, metabolic and hormonal responses to the progressive exercise performed to exhaustion in patients with type 2 diabetes treated with metformin or glyburide. Diabetes, obesity & metabolism, v. 10, n. 3, p. 238-245, 2008Tradução . . Disponível em: https://doi.org/10.1111/j.1463-1326.2006.00690.x. Acesso em: 19 abr. 2024. -
APA
Cunha, M. C., Silva, M. E. R., Machado, H. A., Fukui, R. T., Correia, M. R. S., Santos, R. F., et al. (2008). Cardiovascular, metabolic and hormonal responses to the progressive exercise performed to exhaustion in patients with type 2 diabetes treated with metformin or glyburide. Diabetes, obesity & metabolism, 10( 3), 238-245. doi:10.1111/j.1463-1326.2006.00690.x -
NLM
Cunha MC, Silva MER, Machado HA, Fukui RT, Correia MRS, Santos RF, Wajchenberg BL, Rocha DM, Rondon MUPB, Negrão CE, Ursich MJM (MJM). Cardiovascular, metabolic and hormonal responses to the progressive exercise performed to exhaustion in patients with type 2 diabetes treated with metformin or glyburide [Internet]. Diabetes, obesity & metabolism. 2008 ; 10( 3): 238-245.[citado 2024 abr. 19 ] Available from: https://doi.org/10.1111/j.1463-1326.2006.00690.x -
Vancouver
Cunha MC, Silva MER, Machado HA, Fukui RT, Correia MRS, Santos RF, Wajchenberg BL, Rocha DM, Rondon MUPB, Negrão CE, Ursich MJM (MJM). Cardiovascular, metabolic and hormonal responses to the progressive exercise performed to exhaustion in patients with type 2 diabetes treated with metformin or glyburide [Internet]. Diabetes, obesity & metabolism. 2008 ; 10( 3): 238-245.[citado 2024 abr. 19 ] Available from: https://doi.org/10.1111/j.1463-1326.2006.00690.x - Avaliação da resposta metabólica durante exercício moderado em pacientes com Diabetes Tipo 2 tratadas com metformina(M) ou glibenclamida(G):: comparação com controles normais(C)
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Informações sobre o DOI: 10.1111/j.1463-1326.2006.00690.x (Fonte: oaDOI API)
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