Artigo de periodico

Exercise training improves the net balance of cardiac Ca'EXP2+' handling protein expression in heart failure (2007)

• Autores:
  • Rolim, Natale Pinheiro Lage
  • Medeiros, Alessandra
  • Rosa, Kaleizu T.
  • Mattos, Katt Coelho
  • Irigoyen, Maria Cláudia
  • Krieger, Eduardo Moacyr
  • Krieger, José Eduardo
  • Negrão, C. E.
  • Brum, Patrícia Chakur
• Autores USP: KRIEGER, EDUARDO MOACYR - FM ; KRIEGER, JOSE EDUARDO - FM ; NEGRÃO, CARLOS EDUARDO - EEFE ; BRUM, PATRICIA CHAKUR - EEFE
• Unidades: FM; EEFE
• DOI: 10.1152/physiolgenomics.00188.2006
• Assunto: FISIOLOGIA DO EXERCÍCIO
• Idioma: Inglês
• Resumo: ET in ('alfa''2 IND.A' /'alfa''2 IND.C'ARKO) mice improved exercise tolerance and systolic function. ET slightly reduced cardiac myocyte width, but unchanged ventricular fibrosis in ('alfa''2 IND.A' /'alfa''2 IND.C'ARKO) mice. ET significantly increased the expression of SERCA2 (20%) and phospho-Ser'EXP16`-PLN (63%), phospho-Thr'EXP17'-PLN (211%) in congenic ('alfa''2 IND.A' /'alfa''2 IND.C'ARKO) mice. Furthermore, ET restored NCX and PP1 expression in ('alfa''2 IND.A' /'alfa''2 IND.C'ARKO) to untrained WT mice levels. Thus, we provide evidence that Ca'EXP2+' handling is impaired in this HF model and that overall VF improved upon ET, which was associated to changes in the net balance of cardiac Ca'EXP2+' handling proteinsThe molecular basis of the beneficial effects associated with exercise training (ET) on overall ventricular function (VF) in heart failure (HF) remains unclear. We investigated potential Ca'EXP2+' handling abnormalities and whether ET would improve VF of mice lacking 'alfa''2 IND.A' and 'alfa''2 IND.C'-adrenoceptors ('alfa''2 IND.A' /'alfa''2 IND.C'ARKO) that have sympathetic hyperactivity-induced HF. A cohort of male wild-type (WT) and congenic ('alfa''2 IND.A' /'alfa''2 IND.C'ARKO) mice in a C57BL/J genetic background (5-7 mo of age) was randomly assigned into untrained and trained groups. VF was assessed by two-dimensional guided M-mode echocardiography. Cardiac myocyte width and ventricular fibrosis were evaluated with a computer-assisted morphometric system. Sarcoplasmic reticulum Ca'EXP2+' ATPase (SERCA2), phospholamban (PLN), phospho-Ser'EXP16`-PLN, phospho-Thr'EXP17'-PLN, phosphatase 1 (PP1), and Na+-Ca'EXP2+' exchanger (NCX) were analyzed by Western blotting. ET consisted of 8-wk running sessions of 60 min, 5 days/wk. ('alfa''2 IND.A' /'alfa''2 IND.C'ARKO) mice displayed exercise intolerance, systolic dysfunction, increased cardiac myocyte width, and ventricular fibrosis paralleled by decreased SERCA2 and increased NCX expression levels
• Imprenta:
  • Local: Bethesda
  • Data de publicação: 2007
• Fonte:
  • Título do periódico: Physiological genomics
  • Volume/Número/Paginação/Ano: v. 29, n. 3, p. 246-252, mai. 2007

Informações sobre o DOI: 10.1152/physiolgenomics.00188.2006 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

---

Como citar

A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas

• ABNT

  ROLIM, Natale Pinheiro Lage et al. Exercise training improves the net balance of cardiac Ca'EXP2+' handling protein expression in heart failure. Physiological genomics, v. 29, n. 3, p. 246-252, 2007Tradução . . Disponível em: https://doi.org/10.1152/physiolgenomics.00188.2006. Acesso em: 18 set. 2024.

• APA

  Rolim, N. P. L., Medeiros, A., Rosa, K. T., Mattos, K. C., Irigoyen, M. C., Krieger, E. M., et al. (2007). Exercise training improves the net balance of cardiac Ca'EXP2+' handling protein expression in heart failure. Physiological genomics, 29( 3), 246-252. doi:10.1152/physiolgenomics.00188.2006

• NLM

  Rolim NPL, Medeiros A, Rosa KT, Mattos KC, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Brum PC. Exercise training improves the net balance of cardiac Ca'EXP2+' handling protein expression in heart failure [Internet]. Physiological genomics. 2007 ; 29( 3): 246-252.[citado 2024 set. 18 ] Available from: https://doi.org/10.1152/physiolgenomics.00188.2006

• Vancouver

  Rolim NPL, Medeiros A, Rosa KT, Mattos KC, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Brum PC. Exercise training improves the net balance of cardiac Ca'EXP2+' handling protein expression in heart failure [Internet]. Physiological genomics. 2007 ; 29( 3): 246-252.[citado 2024 set. 18 ] Available from: https://doi.org/10.1152/physiolgenomics.00188.2006

Últimas obras dos mesmos autores vinculados com a USP cadastradas na BDPI:

• O treinamento físico previne a disfunção cardíaca e altera a recaptação de cálcio em um modelo genético de cardiomiopatia induzida por hiperatividade simpática
• Exercise training prevents cardiac dysfunction and altered sarcoplasmic calcium reuptake in a genetic model of cardiomyopathy induced by sympathetic hyperactivity
• Sensibilidade do reflexo pressorreceptor no periodo pos-exercicio fisico em ratos
• O polimorfismo GLU298ASP da Enos está associado à reduzida vasodilatação muscular induzida pelo exercício
• Sensibilidade dos aferentes pressorreceptores em ratos treinados espontaneamente hipertensos
• Exercise training increases the baroreflex control of renal sympathetic nerve activity in spontaneously hypertensive rats
• Efeito do treinamento físico sobre a sensibilidade dos reflexos pressorreceptor e cardiopulmonar em ratos espontaneamente hipertensos
• Effects of acute baroreceptor denervation on arterial pressure and heart rate responses at onset of dynamic exercise in rats
• Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats
• O treinamento físico de baixa intensidade aumenta a sensibilidade dos reflexos pressorreceptor e cardiopulmonar em ratos espontaneamente hipertensos