Trabalho de evento-resumo

Physical training alters skeletal muscle venule reservoir and local control of venous flow in SHR (2005)

• Autores:
  • França, T. R. F.
  • Michelini, Lisete Compagno
• Autor USP: MICHELINI, LISETE COMPAGNO - ICB
• Unidade: ICB
• Assunto: FISIOLOGIA
• Idioma: Português
• Resumo: We observed that training (T)-induced pressure fall and marked exercise hyperemia in SHR are correlated to unexpected skeletal muscles venule growth in addition to capillary angiogenesis (Hypertension 2003; 42:851). We sought now to investigate the functional effects of T-induced venule enlargement. Métodos e Resultados: Male SHR and WKY submitted to T (treadmill, 55% VO2 peak for 3 months) or kept sedentary (S) were instrumented for pressure (AP) and iliac venous flow (FVEN, Transonic) recordings at rest and during graded exercise (0.4 up to 1.4 km/h) on basal condition (VEH infusion) and in the presence of subpressor iv infusions of L-NMMA and HOE-140 (25 µg/kg and 10-20 µg/kg/min, respectively). MAP and FVEN (171±3 mmHg, 1.58±0.28 ml/min/g, p<0.05) were increased in SHRS (vs WKYS). T was equally effective to improve treadmill performance (~40%) in both groups but fall in AP (-8%) and resting FVEN (30% reduction in outflow) were only observed in SHRT. During steady-state exercise MAP was similarly increased in the 4 groups (+17±3 mmHg) but maximal FVEN was higher after T (+147% vs +67%, T vs S groups, p<0.05, FVEN being almost maximal since the onset of exercise only in SHRT). Exercise in the presence of B2 receptor or NOS blockade caused similar decrease of FVEN in all groups, except for L-NMMA-treated SHRT (increase of 44% over respective VEH control was observed). Volemia, measured by Evans blue dilution at the end of experiments, was decreased inSHRS (-19% vs WKYS), but normalized after T. Accommodation of larger volemia at rest and higher blood inflow at onset of exercise in the SHR skeletal muscle are functional beneficial adjustments of T-induced venule growth. In the SHRT, the larger skeletal muscle venous outflow in the presence of NOS blockade reinforces the importance of exercise to facilitate NO-mediated vasodilation and confirms functionally the presence of increased skeletal muscle venous reservoir
• Imprenta:
  • Editora: Federação de Sociedades de Biologia Experimental
  • Local: Águas de Lindóia, São Paulo
  • Data de publicação: 2005
• Fonte:
  • Título do periódico: Resumos
• Nome do evento: Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE

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• ABNT

  FRANÇA, T. R. F. e MICHELINI, Lisete Compagno. Physical training alters skeletal muscle venule reservoir and local control of venous flow in SHR. 2005, Anais.. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental, 2005. . Acesso em: 25 abr. 2024.

• APA

  França, T. R. F., & Michelini, L. C. (2005). Physical training alters skeletal muscle venule reservoir and local control of venous flow in SHR. In Resumos. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental.

• NLM

  França TRF, Michelini LC. Physical training alters skeletal muscle venule reservoir and local control of venous flow in SHR. Resumos. 2005 ;[citado 2024 abr. 25 ]

• Vancouver

  França TRF, Michelini LC. Physical training alters skeletal muscle venule reservoir and local control of venous flow in SHR. Resumos. 2005 ;[citado 2024 abr. 25 ]

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