Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma (2002)
- Autores:
- Autores USP: SOUSA, SUZANA CANTANHEDE ORSINI MACHADO DE - FO ; PINTO JUNIOR, DECIO DOS SANTOS - FO
- Unidade: FO
- DOI: 10.1046/j.0904-2512.2001.10012.x
- Assuntos: PROTEÍNAS; CARCINOMA DE CÉLULAS ESCAMOSAS
- Idioma: Inglês
- Resumo: BACKGROUND: Studies have addressed the relevance of c-Jun and c-Fos proteins in cancer development. In the present study, the expression of c-Jun and c-Fos, the major components of transcription factor activator protein (AP1), were evaluated to determine possible alterations to these factors in oral squamous cell carcinoma (OSCC). METHODS: Fifteen cases of normal oral mucosa and 20 cases of OSCC were retrieved from the Archives of the Surgical Pathology Service at the University of Sao Paulo. The samples of normal oral mucosa or OSCC originated from different oral mucosal sites. Tissues were submitted for immunohistochemical analysis to detect c-Jun and c-Fos proteins. The OSCC was classified as well, intermediate or poorly differentiated. RESULTS: The results showed that both c-Jun and c-Fos are expressed in normal oral mucosa and in OSCC. In normal mucosa, immunoreactivity for c-Jun was detected in the cytoplasm of the upper basal layers, while in OSCC, c-Jun was detected in the nuclei of the cells. C-Fos expression was observed in the nuclei of cells, both in normal mucosa and in OSCC, but its expression varied according to the cell layer in normal mucosa, and the differentiation of OSCC. CONCLUSIONS: The nuclear expression of c-Jun in OSCC, in contrast to its cytoplasmic expression in normal oral mucosa, indicates that c-Jun may have a role in the development of oral cancer. In contrast, the absence of both c-Jun and c-Fos in poorly differentiatedcarcinoma might be useful in understanding the cell cycle events important in uncontrolled cell growth
- Imprenta:
- Fonte:
- Título do periódico: Journal of Oral Pathology & Medicine
- ISSN: 0904-2512
- Volume/Número/Paginação/Ano: v. 31, n. 2, p.78-81, February 2002
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
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ABNT
SOUSA, Suzana Cantanhede Orsini Machado de et al. Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma. Journal of Oral Pathology & Medicine, v. 31, n. 2, p. 78-81, 2002Tradução . . Disponível em: https://doi.org/10.1046/j.0904-2512.2001.10012.x. Acesso em: 20 abr. 2024. -
APA
Sousa, S. C. O. M. de, Mesquita, R. A., Gutkind, S., & Pinto Júnior, D. dos S. (2002). Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma. Journal of Oral Pathology & Medicine, 31( 2), 78-81. doi:10.1046/j.0904-2512.2001.10012.x -
NLM
Sousa SCOM de, Mesquita RA, Gutkind S, Pinto Júnior D dos S. Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma [Internet]. Journal of Oral Pathology & Medicine. 2002 ; 31( 2): 78-81.[citado 2024 abr. 20 ] Available from: https://doi.org/10.1046/j.0904-2512.2001.10012.x -
Vancouver
Sousa SCOM de, Mesquita RA, Gutkind S, Pinto Júnior D dos S. Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma [Internet]. Journal of Oral Pathology & Medicine. 2002 ; 31( 2): 78-81.[citado 2024 abr. 20 ] Available from: https://doi.org/10.1046/j.0904-2512.2001.10012.x - Estudo das fibras oxitalanicas em hiperplasias gengivais, induzidas por drogas
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Informações sobre o DOI: 10.1046/j.0904-2512.2001.10012.x (Fonte: oaDOI API)
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