Expression of transforming growth factor 'alfa' in gastric epithelium of sialoadenectomized suckling rats submitted to fasting (2004)
- Authors:
- USP affiliated authors: GAMA, PATRICIA - ICB ; ALVARES, ELIANA PARISI - ICB
- Unidade: ICB
- Assunto: HISTOLOGIA
- Language: Inglês
- Abstract: Transforming growth factor ? (TGF ?), a member of the epidermal growth factor (EGF) family of peptides, induces a wide variety of biological responses, from mitotical stimulus to regulation of differentiation. The gastrointestinal tract of suckling rats receives EGF mainly from milk and TGF ? from saliva. We demonstrated that fasting enhances cell proliferation in the gastric epithelium of suckling rats. Sialoadenectomy was performed in this model to determine the expression of growth factors in the absence of stimulus from saliva, as well as from milk (in fasting rats). 14-day-old suckling rats had its salivary glands ablated or were sham operated. Fed or fasted rats were sacrificed at 18 days. Immunohistochemical analysis of TGF 'alfa' expression was made and positive cells in the gastric epithelium (surface mucous cells and glandular cells) were counted. Fasting caused significant increase in the TGF ? expression in surface mucous cells and glandular cells (parietal and chief cells also). Sialoadenectomy caused a significant decrease in this expression in fasting animals. We suggest that TGF 'alfa' from saliva may have a stimulatory function over the expression of TGF ? in gastric epithelium more important than EGF or other factors in milk. Higher expression of TGF ? was correlated with enhanced cell proliferation in gastric epithelium
- Imprenta:
- Source:
- Título do periódico: Abstracts
- Conference titles: Congress of the Brazilian Society for Cell Biology
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ABNT
LESTINGI, Jean F. P. et al. Expression of transforming growth factor 'alfa' in gastric epithelium of sialoadenectomized suckling rats submitted to fasting. 2004, Anais.. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2004. . Acesso em: 19 set. 2024. -
APA
Lestingi, J. F. P., Nishitokukado, Y., Gama, P., & Alvares, E. P. (2004). Expression of transforming growth factor 'alfa' in gastric epithelium of sialoadenectomized suckling rats submitted to fasting. In Abstracts. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Lestingi JFP, Nishitokukado Y, Gama P, Alvares EP. Expression of transforming growth factor 'alfa' in gastric epithelium of sialoadenectomized suckling rats submitted to fasting. Abstracts. 2004 ;[citado 2024 set. 19 ] -
Vancouver
Lestingi JFP, Nishitokukado Y, Gama P, Alvares EP. Expression of transforming growth factor 'alfa' in gastric epithelium of sialoadenectomized suckling rats submitted to fasting. Abstracts. 2004 ;[citado 2024 set. 19 ] - Expression of the transforming growth factor beta isoforms and receptors in gastric mucosa of suckling rats: effects of hydrocortisone
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- Differential effects of fasting on corticosterone levels in suckling and adult rats: consequences to the gastric epithelium
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