The frequent rupture of the outer mitochondrial membrane seen in apoptotic cells results of the loss of the selective permeability of the inner mitochondrial membrane wich covers a swollen mitochondrial matrix herniating, through yhe rupture, to the cytoplasm. This is the morphology of the mitochondrial permeability transition (MPT) (2004)
- Autores:
- Autores USP: COLQUHOUN, ALISON - ICB ; BELIZARIO, JOSE ERNESTO - ICB
- Unidade: ICB
- Assuntos: HISTOLOGIA; FARMACOLOGIA
- Idioma: Inglês
- Resumo: The information conveyed in the above title represents a novel contribution to the study of apoptosis. The MPT is a state of the organelle in which in addition to the changes cited in the title there is collapse of the mitochondrial transmembrane potential ('delta' 'psi' m). It occurs in apoptotic and possibly also in necrotic cells. We observed, with the TEM, MPT in 5 different types of rat tissue cells in apoptosis and in the apoptotic cells of six different lines of cultured cells. From the following cell lines HL-60, HeLa, WEHI-164 and a special batch of PC-12 cells, eight samples subjected to various apoptogenic agents were studied morphometrically to evaluate the mitochondrial volumes in µm3 and the volume fraction of the cytoplasm occupied by mitochondria with ruptured outer membrane in cells at early stages of apoptosis and also in mitochondria with no ruptured outer membrane from companion non apoptotic cells. A considerable fraction, some 65% (47-86%), of the total mitochondrial volume of the apoptotic cells is occupied by mitochondria expressing permeability transition
- Imprenta:
- Fonte:
- Título do periódico: Abstracts
- Nome do evento: Congress of the Brazilian Society for Cell Biology
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ABNT
SESSO, Antonio et al. The frequent rupture of the outer mitochondrial membrane seen in apoptotic cells results of the loss of the selective permeability of the inner mitochondrial membrane wich covers a swollen mitochondrial matrix herniating, through yhe rupture, to the cytoplasm. This is the morphology of the mitochondrial permeability transition (MPT). 2004, Anais.. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2004. . Acesso em: 16 abr. 2024. -
APA
Sesso, A., Marques, M. M., Monteiro, M. M. T., Schumacher, R. I., Colquhoun, A., Belizário, J. E., et al. (2004). The frequent rupture of the outer mitochondrial membrane seen in apoptotic cells results of the loss of the selective permeability of the inner mitochondrial membrane wich covers a swollen mitochondrial matrix herniating, through yhe rupture, to the cytoplasm. This is the morphology of the mitochondrial permeability transition (MPT). In Abstracts. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Sesso A, Marques MM, Monteiro MMT, Schumacher RI, Colquhoun A, Belizário JE, Konno SN, Felix TB, Botelho LAA, Santos VZC, Silva GR da, Higuchi M de L, Kawakami JT. The frequent rupture of the outer mitochondrial membrane seen in apoptotic cells results of the loss of the selective permeability of the inner mitochondrial membrane wich covers a swollen mitochondrial matrix herniating, through yhe rupture, to the cytoplasm. This is the morphology of the mitochondrial permeability transition (MPT). Abstracts. 2004 ;[citado 2024 abr. 16 ] -
Vancouver
Sesso A, Marques MM, Monteiro MMT, Schumacher RI, Colquhoun A, Belizário JE, Konno SN, Felix TB, Botelho LAA, Santos VZC, Silva GR da, Higuchi M de L, Kawakami JT. The frequent rupture of the outer mitochondrial membrane seen in apoptotic cells results of the loss of the selective permeability of the inner mitochondrial membrane wich covers a swollen mitochondrial matrix herniating, through yhe rupture, to the cytoplasm. This is the morphology of the mitochondrial permeability transition (MPT). Abstracts. 2004 ;[citado 2024 abr. 16 ] - The frequent rupture of the outer mitochondrial membrane seen in apoptotic cells results of the loss of the selective permeability of the inner mitochondrial membrane wich covers a swollen mitochondrial matrix herniating, through yhe rupture, to the cytoplasm. This is the morphology of the mitochondrial permeability transition (MPT)
- In the early stages of the mitochondrial permeability transition (MPT) the rupture of outer membrane is small sized. Correlation between apoptotic indices and MPT
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