Artigo de periodico

Relationship of subgingival and salivary microbiota to gingival overgrowth in heart transplant patients following cyclosporin a therapy (2004)

• Autores:
  • Romito, Giuseppe Alexandre
  • Saraiva, Luciana
  • Pustiglioni, Alessandro Nautili
  • Stolf, Noedir Antônio Groppo
  • Pustiglioni, Francisco Emílio
  • Lotufo, Roberto Fraga Moreira
• Autores USP: ROMITO, GIUSEPPE ALEXANDRE - FO ; PUSTIGLIONI, FRANCISCO EMILIO - FO ; LOTUFO, ROBERTO FRAGA MOREIRA - FO
• Unidade: FO
• Assuntos: CICLOSPORINAS; TRANSPLANTE DE CORAÇÃO; PERIODONTITE; HIPERPLASIA GENGIVAL
• Idioma: Inglês
• Resumo: BACKGROUND: Severe gingival overgrowth (GO) is induced in patients taking cyclosporin A (CsA) following organ transplantation. Determining which patient will develop GO is still not possible. The purpose of this study was to establish an association between CsA and gingival overgrowth in heart transplant patients taking into account periodontal and microbiological conditions. METHODS: Thirty patients (10 female, 20 male; range: 13 to 67 years; mean age: 44.89) undergoing CsA treatment were evaluated using the gingival index (GI), plaque index (PI), probing depth (PD), and clinical attachment level (CAL). Subgingival samples collected from the deepest site of each quadrant and saliva samples were submitted to microbial analysis. All patients had at least 12 teeth. Exclusion criteria were the use of antibiotics and/or having undergone periodontal treatment 6 months prior to the study. Patients were divided in two groups: with gingival (GO+) and without gingival overgrowth (GO-). RESULTS: There were no statistically significant differences between the GO+ and GO- groups when CsA dosage, time since transplant, GI, PI, PD, and CAL were compared. Microbiological examination of the subgingival samples detected the following microorganisms: Actinobacillus actinomycetemcomitans (23%), Porphyromonas gingivalis (36%), Prevotella intermedia (93%), Fusobacterium sp. (66%), Campylobacter rectus (30%), Micromonas micros (66%), enteric rods (0%), and yeasts (30%).A positive association between M. micros and the GO+ group was found (P < 0.001). Yeasts were detected in 30% of the subgingival and saliva samples. CONCLUSIONS: Clinical parameters were not sufficient to determine which patients would develop GO. However, colonization by M. micros might play a role in the etiology of GO
• Imprenta:
  • Local: Chicago
  • Data de publicação: 2004
• Fonte:
  • Título do periódico: Journal of Periodontology
  • ISSN: 0022-3492
  • Volume/Número/Paginação/Ano: v. 75, n. 7, p.918-924, July 2004

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• ABNT

  ROMITO, Giuseppe Alexandre et al. Relationship of subgingival and salivary microbiota to gingival overgrowth in heart transplant patients following cyclosporin a therapy. Journal of Periodontology, v. 75, n. 7, p. 918-924, 2004Tradução . . Acesso em: 16 abr. 2024.

• APA

  Romito, G. A., Saraiva, L., Pustiglioni, A. N., Stolf, N. A. G., Pustiglioni, F. E., & Lotufo, R. F. M. (2004). Relationship of subgingival and salivary microbiota to gingival overgrowth in heart transplant patients following cyclosporin a therapy. Journal of Periodontology, 75( 7), 918-924.

• NLM

  Romito GA, Saraiva L, Pustiglioni AN, Stolf NAG, Pustiglioni FE, Lotufo RFM. Relationship of subgingival and salivary microbiota to gingival overgrowth in heart transplant patients following cyclosporin a therapy. Journal of Periodontology. 2004 ; 75( 7): 918-924.[citado 2024 abr. 16 ]

• Vancouver

  Romito GA, Saraiva L, Pustiglioni AN, Stolf NAG, Pustiglioni FE, Lotufo RFM. Relationship of subgingival and salivary microbiota to gingival overgrowth in heart transplant patients following cyclosporin a therapy. Journal of Periodontology. 2004 ; 75( 7): 918-924.[citado 2024 abr. 16 ]

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