Location of DNA repair genes in relation to gene transfer islands (2003)
- Autores:
- Autor USP: MENCK, CARLOS FREDERICO MARTINS - ICB
- Unidade: ICB
- Assunto: MICROBIOLOGIA
- Idioma: Português
- Resumo: Horizontal gene transfer (HGT) is a collective name for processes that permit the exchange of DNA among organisms of different species, even between distant evolutionary lineages; thus, the most reliable method for detection of HGT events is phylogenetic analysis and recognition of unusual patterns of evolution. HGT of a given gene is strongly correlated with its gene function: "informational genes" (those participating in transcription, translation, replication and DNA repair) are less prone to be horizontally transferred than "operational genes" (those involved in housekeeping functions). In this work, we describe the location of DNA repair genes from two sequenced Xanthomonas genomes, Xanthomonas axonopodis pv citri and Xanthomonas campestris pv campestris, in relation to potentially "gene transfer islands" found in these genomes. The search for horizontally transferred genes was made by analysis of unexpected best matches, via BlastP algorithm, and the repair genes candidates to HGT were analyzed in an evolutionary manner, via phylogenetic reconstruction.For nearly one hundred repair genes of both Xanthomonas, distributed along seven repair pathways, almost thirty percent of DNA repair genes are located in the given "gene transfer islands" or in the vicinity. From these, we focused our phylogenetic analysis in genes belonging to direct repair, nucleotide excision repair, base excision repair and mismatch repair pathways. Theproximity of Xanthomonas genes with orthologs of unrelated organisms to define possible horizontally transferred genes is a widely accepted assumption, and in this way we identified 10 repair genes potentially introduced via HGT in both Xanthomonas, including phr, ada, alkA, ogt and uvr genes
- Imprenta:
- Editora: Comissão de Pesquisa do ICB/USP
- Local: São Paulo
- Data de publicação: 2003
- Fonte:
- Título do periódico: Resumos
- Nome do evento: Congresso Instituto Ciências Biomédicas, IV
-
ABNT
LIMA, Wanessa Cristina de e MENCK, Carlos Frederico Martins e PINHEIRO, M. M. Location of DNA repair genes in relation to gene transfer islands. 2003, Anais.. São Paulo: Comissão de Pesquisa do ICB/USP, 2003. . Acesso em: 24 abr. 2024. -
APA
Lima, W. C. de, Menck, C. F. M., & Pinheiro, M. M. (2003). Location of DNA repair genes in relation to gene transfer islands. In Resumos. São Paulo: Comissão de Pesquisa do ICB/USP. -
NLM
Lima WC de, Menck CFM, Pinheiro MM. Location of DNA repair genes in relation to gene transfer islands. Resumos. 2003 ;[citado 2024 abr. 24 ] -
Vancouver
Lima WC de, Menck CFM, Pinheiro MM. Location of DNA repair genes in relation to gene transfer islands. Resumos. 2003 ;[citado 2024 abr. 24 ] - Restoring DNA repair capacity of cells from three distinct diseases by XPD gene-recombinant adenovirus
- DNA-Based biological dosimeters for the assessment of photo protection of sunscreens
- DNA repair and consequences of DNA damage: in the fight against and causing cancer!
- ATR DNA damage response after UVB in polimerase ETA deficient cells
- UV light-induced apoptosis is dependent of damaged DNA replication in mammalian cells
- Construção de um adenovírus recombinante portando o cDNA do gene PHR2 de cana-de-açúcar
- XPD transduction in human cells deficient in DNA repair by recombinant adenovirus
- Construction of an adenoviral vector carrying the cDNA of XPD gene for complementation of human cells deficient in dna repair
- Estudos da função da proteína THI1 através de ensaios bioquímicos
- Introdução do gene de fotoliase em células humanas
Como citar
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
