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Artigo de periodico
Exploring Nirmatrelvir derivatives through P2 substituent modifications and warhead innovations targeting the main protease of SARS-CoV-2 (2025)
Martins, Felipe Cardoso Prado ; Lang, Johannes; Rocho, Fernanda dos Reis ; Wang, Xianxian; Bonatto, Vinícius ; Lameira, Jerônimo ; Klein, Christian ; Montanari, Carlos Alberto
Source: Archiv der Pharmazie. Unidade: IQSC
Subjects: ENZIMAS, COVID-19
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ABNT
MARTINS, Felipe Cardoso Prado et al. Exploring Nirmatrelvir derivatives through P2 substituent modifications and warhead innovations targeting the main protease of SARS-CoV-2. Archiv der Pharmazie, v. 358, p. e70158, 2025Tradução . . Disponível em: https://doi.org/10.1002/ardp.70158. Acesso em: 03 dez. 2025.
APA
Martins, F. C. P., Lang, J., Rocho, F. dos R., Wang, X., Bonatto, V., Lameira, J., et al. (2025). Exploring Nirmatrelvir derivatives through P2 substituent modifications and warhead innovations targeting the main protease of SARS-CoV-2. Archiv der Pharmazie, 358, e70158. doi:10.1002/ardp.70158
NLM
Martins FCP, Lang J, Rocho F dos R, Wang X, Bonatto V, Lameira J, Klein C, Montanari CA. Exploring Nirmatrelvir derivatives through P2 substituent modifications and warhead innovations targeting the main protease of SARS-CoV-2 [Internet]. Archiv der Pharmazie. 2025 ; 358 e70158.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1002/ardp.70158
Vancouver
Martins FCP, Lang J, Rocho F dos R, Wang X, Bonatto V, Lameira J, Klein C, Montanari CA. Exploring Nirmatrelvir derivatives through P2 substituent modifications and warhead innovations targeting the main protease of SARS-CoV-2 [Internet]. Archiv der Pharmazie. 2025 ; 358 e70158.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1002/ardp.70158
Artigo de periodico
Fat or flat?: The impact of dipole moment vectors on non-covalent interactions between aromatic tags and macromolecules (2025)
Holub, Josef; Jílková, Adéla; Lemke, Carina; Cianni, Lorenzo ; Spiwoková, Petra; Horn, Martin; Breuer, Christian; Leontovyc, Adrian; Brynda, Jiří; Mertlíková-Kaiserová, Helena; Chanová, Marta; Rocho, Fernanda dos Reis ; Montanari, Carlos Alberto ; El-Sakkary, Nelly; Caffrey, Conor R.; Gütschow, Michael ; Hnyk, Drahomír; Mares, Michael; Fanfrlík, Jindřich
Source: Inorganic Chemistry Frontiers. Unidade: IQSC
Subjects: CARBONO, FÁRMACOS
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HOLUB, Josef et al. Fat or flat?: The impact of dipole moment vectors on non-covalent interactions between aromatic tags and macromolecules. Inorganic Chemistry Frontiers, 2025Tradução . . Disponível em: https://doi.org/10.1039/d5qi01546d. Acesso em: 03 dez. 2025.
APA
Holub, J., Jílková, A., Lemke, C., Cianni, L., Spiwoková, P., Horn, M., et al. (2025). Fat or flat?: The impact of dipole moment vectors on non-covalent interactions between aromatic tags and macromolecules. Inorganic Chemistry Frontiers. doi:10.1039/d5qi01546d
NLM
Holub J, Jílková A, Lemke C, Cianni L, Spiwoková P, Horn M, Breuer C, Leontovyc A, Brynda J, Mertlíková-Kaiserová H, Chanová M, Rocho F dos R, Montanari CA, El-Sakkary N, Caffrey CR, Gütschow M, Hnyk D, Mares M, Fanfrlík J. Fat or flat?: The impact of dipole moment vectors on non-covalent interactions between aromatic tags and macromolecules [Internet]. Inorganic Chemistry Frontiers. 2025 ;[citado 2025 dez. 03 ] Available from: https://doi.org/10.1039/d5qi01546d
Vancouver
Holub J, Jílková A, Lemke C, Cianni L, Spiwoková P, Horn M, Breuer C, Leontovyc A, Brynda J, Mertlíková-Kaiserová H, Chanová M, Rocho F dos R, Montanari CA, El-Sakkary N, Caffrey CR, Gütschow M, Hnyk D, Mares M, Fanfrlík J. Fat or flat?: The impact of dipole moment vectors on non-covalent interactions between aromatic tags and macromolecules [Internet]. Inorganic Chemistry Frontiers. 2025 ;[citado 2025 dez. 03 ] Available from: https://doi.org/10.1039/d5qi01546d
Artigo de periodico
Differential specificity of SARS-CoV-2 main protease variants on peptide versus protein-based substrates (2024)
Rocho, Fernanda dos Reis ; Snipas, Scott J.; Shamim, Anwar ; Rut, Wioletta; Drag, Marcin; Montanari, Carlos Alberto
Source: The FEBS Journal. Unidade: IQSC
Subjects: COVID-19, PEPTÍDEOS, PROTEÍNAS
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ABNT
ROCHO, Fernanda dos Reis et al. Differential specificity of SARS-CoV-2 main protease variants on peptide versus protein-based substrates. The FEBS Journal, v. 291, n. 1, p. 61–69, 2024Tradução . . Disponível em: https://doi.org/10.1111/febs.16970. Acesso em: 03 dez. 2025.
APA
Rocho, F. dos R., Snipas, S. J., Shamim, A., Rut, W., Drag, M., & Montanari, C. A. (2024). Differential specificity of SARS-CoV-2 main protease variants on peptide versus protein-based substrates. The FEBS Journal, 291( 1), 61–69. doi:10.1111/febs.16970
NLM
Rocho F dos R, Snipas SJ, Shamim A, Rut W, Drag M, Montanari CA. Differential specificity of SARS-CoV-2 main protease variants on peptide versus protein-based substrates [Internet]. The FEBS Journal. 2024 ; 291( 1): 61–69.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1111/febs.16970
Vancouver
Rocho F dos R, Snipas SJ, Shamim A, Rut W, Drag M, Montanari CA. Differential specificity of SARS-CoV-2 main protease variants on peptide versus protein-based substrates [Internet]. The FEBS Journal. 2024 ; 291( 1): 61–69.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1111/febs.16970
Artigo de periodico
Novel selective proline-based peptidomimetics for human cathepsin K inhibition (2024)
Martins, Felipe Cardoso Prado ; Rocho, Fernanda dos Reis ; Bonatto, Vinícius ; Batista, Pedro Henrique Jatai ; Lameira, Jerônimo ; Leitão, Andrei ; Montanari, Carlos Alberto
Source: Bioorganic & Medicinal Chemistry Letters. Unidade: IQSC
Subjects: INIBIDORES QUÍMICOS, OSTEOPOROSE
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ABNT
MARTINS, Felipe Cardoso Prado et al. Novel selective proline-based peptidomimetics for human cathepsin K inhibition. Bioorganic & Medicinal Chemistry Letters, v. 110, p. 129887, 2024Tradução . . Disponível em: https://doi.org/10.1016/j.bmcl.2024.129887. Acesso em: 03 dez. 2025.
APA
Martins, F. C. P., Rocho, F. dos R., Bonatto, V., Batista, P. H. J., Lameira, J., Leitão, A., & Montanari, C. A. (2024). Novel selective proline-based peptidomimetics for human cathepsin K inhibition. Bioorganic & Medicinal Chemistry Letters, 110, 129887. doi:10.1016/j.bmcl.2024.129887
NLM
Martins FCP, Rocho F dos R, Bonatto V, Batista PHJ, Lameira J, Leitão A, Montanari CA. Novel selective proline-based peptidomimetics for human cathepsin K inhibition [Internet]. Bioorganic & Medicinal Chemistry Letters. 2024 ;110 129887.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmcl.2024.129887
Vancouver
Martins FCP, Rocho F dos R, Bonatto V, Batista PHJ, Lameira J, Leitão A, Montanari CA. Novel selective proline-based peptidomimetics for human cathepsin K inhibition [Internet]. Bioorganic & Medicinal Chemistry Letters. 2024 ;110 129887.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmcl.2024.129887
Tese (Doutorado)
Investigando a especificidade e inibição da principal protease do SARS-CoV-2 e suas variantes (2023)
Rocho, Fernanda dos Reis ; Montanari, Carlos Alberto (Orientador)
Unidade: IQSC
Subjects: ENZIMAS, ENZIMAS PROTEOLÍTICAS
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ABNT
ROCHO, Fernanda dos Reis. Investigando a especificidade e inibição da principal protease do SARS-CoV-2 e suas variantes. 2023. Tese (Doutorado) – Universidade de São Paulo, São Carlos, 2023. Disponível em: https://www.teses.usp.br/teses/disponiveis/75/75133/tde-29012024-111014/. Acesso em: 03 dez. 2025.
APA
Rocho, F. dos R. (2023). Investigando a especificidade e inibição da principal protease do SARS-CoV-2 e suas variantes (Tese (Doutorado). Universidade de São Paulo, São Carlos. Recuperado de https://www.teses.usp.br/teses/disponiveis/75/75133/tde-29012024-111014/
NLM
Rocho F dos R. Investigando a especificidade e inibição da principal protease do SARS-CoV-2 e suas variantes [Internet]. 2023 ;[citado 2025 dez. 03 ] Available from: https://www.teses.usp.br/teses/disponiveis/75/75133/tde-29012024-111014/
Vancouver
Rocho F dos R. Investigando a especificidade e inibição da principal protease do SARS-CoV-2 e suas variantes [Internet]. 2023 ;[citado 2025 dez. 03 ] Available from: https://www.teses.usp.br/teses/disponiveis/75/75133/tde-29012024-111014/
Artigo de periodico
Nitriles: an attractive approach to the development of covalent inhibitors (2023)
Bonatto, Vinícius ; Lameiro, Rafael da Fonseca ; Rocho, Fernanda dos Reis ; Lameira, Jerônimo ; Leitão, Andrei ; Montanari, Carlos Alberto
Source: RSC Medicinal Chemistry. Unidade: IQSC
Subjects: QUÍMICA MÉDICA, NITRILAS, MEDICAMENTO, LIGANTES
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ABNT
BONATTO, Vinícius et al. Nitriles: an attractive approach to the development of covalent inhibitors. RSC Medicinal Chemistry, v. 14, p. 201-217, 2023Tradução . . Disponível em: https://doi.org/10.1039/D2MD00204C. Acesso em: 03 dez. 2025.
APA
Bonatto, V., Lameiro, R. da F., Rocho, F. dos R., Lameira, J., Leitão, A., & Montanari, C. A. (2023). Nitriles: an attractive approach to the development of covalent inhibitors. RSC Medicinal Chemistry, 14, 201-217. doi:10.1039/D2MD00204C
NLM
Bonatto V, Lameiro R da F, Rocho F dos R, Lameira J, Leitão A, Montanari CA. Nitriles: an attractive approach to the development of covalent inhibitors [Internet]. RSC Medicinal Chemistry. 2023 ; 14 201-217.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1039/D2MD00204C
Vancouver
Bonatto V, Lameiro R da F, Rocho F dos R, Lameira J, Leitão A, Montanari CA. Nitriles: an attractive approach to the development of covalent inhibitors [Internet]. RSC Medicinal Chemistry. 2023 ; 14 201-217.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1039/D2MD00204C
Trabalho de evento-resumo
Putative in silico binding modes of nitrile-based peptoids as cysteine protease inhibitors (2022)
Matos, Thiago Kelvin Brito ; Alves, Luana; Santos, Deborah Araujo dos; Cendron, Rodrigo; Rocho, Fernanda dos Reis ; Montanari, Carlos Alberto ; Leitão, Andrei
Source: Pôster. Conference titles: Reunião Anual da Sociedade Brasileira de Quimica - RASBQ. Unidades: IQSC, FZEA
Subjects: INIBIÇÃO, ACOPLAGEM
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ABNT
MATOS, Thiago Kelvin Brito et al. Putative in silico binding modes of nitrile-based peptoids as cysteine protease inhibitors. 2022, Anais.. São Paulo: Instituto de Química de São Carlos, Universidade de São Paulo, 2022. Disponível em: https://www.eventweb.com.br/45rasbq/specific-files/manuscripts/45rasbq/806_1647372714.pdf. Acesso em: 03 dez. 2025.
APA
Matos, T. K. B., Alves, L., Santos, D. A. dos, Cendron, R., Rocho, F. dos R., Montanari, C. A., & Leitão, A. (2022). Putative in silico binding modes of nitrile-based peptoids as cysteine protease inhibitors. In Pôster. São Paulo: Instituto de Química de São Carlos, Universidade de São Paulo. Recuperado de https://www.eventweb.com.br/45rasbq/specific-files/manuscripts/45rasbq/806_1647372714.pdf
NLM
Matos TKB, Alves L, Santos DA dos, Cendron R, Rocho F dos R, Montanari CA, Leitão A. Putative in silico binding modes of nitrile-based peptoids as cysteine protease inhibitors [Internet]. Pôster. 2022 ;[citado 2025 dez. 03 ] Available from: https://www.eventweb.com.br/45rasbq/specific-files/manuscripts/45rasbq/806_1647372714.pdf
Vancouver
Matos TKB, Alves L, Santos DA dos, Cendron R, Rocho F dos R, Montanari CA, Leitão A. Putative in silico binding modes of nitrile-based peptoids as cysteine protease inhibitors [Internet]. Pôster. 2022 ;[citado 2025 dez. 03 ] Available from: https://www.eventweb.com.br/45rasbq/specific-files/manuscripts/45rasbq/806_1647372714.pdf
Artigo de periodico
A patent review on cathepsin K inhibitors to treat osteoporosis (2011 – 2021) (2022)
Rocho, Fernanda dos Reis ; Bonatto, Vinícius ; Lameiro, Rafael da Fonseca ; Lameira, Jerônimo ; Leitão, Andrei ; Montanari, Carlos Alberto
Source: Expert Opinion on Therapeutic Patents. Unidade: IQSC
Subjects: BIOQUÍMICA, OSTEOPOROSE, NITRILAS
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ABNT
ROCHO, Fernanda dos Reis et al. A patent review on cathepsin K inhibitors to treat osteoporosis (2011 – 2021). Expert Opinion on Therapeutic Patents, v. 32, n. 5, p. 561-573, 2022Tradução . . Disponível em: https://doi.org/10.1080/13543776.2022.2040480. Acesso em: 03 dez. 2025.
APA
Rocho, F. dos R., Bonatto, V., Lameiro, R. da F., Lameira, J., Leitão, A., & Montanari, C. A. (2022). A patent review on cathepsin K inhibitors to treat osteoporosis (2011 – 2021). Expert Opinion on Therapeutic Patents, 32( 5), 561-573. doi:10.1080/13543776.2022.2040480
NLM
Rocho F dos R, Bonatto V, Lameiro R da F, Lameira J, Leitão A, Montanari CA. A patent review on cathepsin K inhibitors to treat osteoporosis (2011 – 2021) [Internet]. Expert Opinion on Therapeutic Patents. 2022 ; 32( 5): 561-573.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1080/13543776.2022.2040480
Vancouver
Rocho F dos R, Bonatto V, Lameiro R da F, Lameira J, Leitão A, Montanari CA. A patent review on cathepsin K inhibitors to treat osteoporosis (2011 – 2021) [Internet]. Expert Opinion on Therapeutic Patents. 2022 ; 32( 5): 561-573.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1080/13543776.2022.2040480
Artigo de periodico
Nitrile-based peptoids as cysteine protease inhibitors (2021)
Souza, Luana Alves Galvão de; Santos, Deborah Araujo dos; Cendron, Rodrigo; Rocho, Fernanda dos Reis ; Matos, Thiago Kelvin Brito ; Leitão, Andrei ; Montanari, Carlos Alberto
Source: Bioorganic & Medicinal Chemistry: the tetrahedron journal for research at the interface of chemistry and biology. Unidade: IQSC
Subjects: BIOQUÍMICA, NITRILAS
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ABNT
SOUZA, Luana Alves Galvão de et al. Nitrile-based peptoids as cysteine protease inhibitors. Bioorganic & Medicinal Chemistry: the tetrahedron journal for research at the interface of chemistry and biology, p. 116211, 2021Tradução . . Disponível em: https://doi.org/10.1016/j.bmc.2021.116211. Acesso em: 03 dez. 2025.
APA
Souza, L. A. G. de, Santos, D. A. dos, Cendron, R., Rocho, F. dos R., Matos, T. K. B., Leitão, A., & Montanari, C. A. (2021). Nitrile-based peptoids as cysteine protease inhibitors. Bioorganic & Medicinal Chemistry: the tetrahedron journal for research at the interface of chemistry and biology, 116211. doi:10.1016/j.bmc.2021.116211
NLM
Souza LAG de, Santos DA dos, Cendron R, Rocho F dos R, Matos TKB, Leitão A, Montanari CA. Nitrile-based peptoids as cysteine protease inhibitors [Internet]. Bioorganic & Medicinal Chemistry: the tetrahedron journal for research at the interface of chemistry and biology. 2021 ;116211.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmc.2021.116211
Vancouver
Souza LAG de, Santos DA dos, Cendron R, Rocho F dos R, Matos TKB, Leitão A, Montanari CA. Nitrile-based peptoids as cysteine protease inhibitors [Internet]. Bioorganic & Medicinal Chemistry: the tetrahedron journal for research at the interface of chemistry and biology. 2021 ;116211.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmc.2021.116211
Artigo de periodico
Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L (2021)
Cianni, Lorenzo ; Rocho, Fernanda dos Reis ; Bonatto, Vinícius ; Martins, Felipe Cardoso Prado ; Lameira, Jerônimo ; Leitão, Andrei ; Montanari, Carlos Alberto ; Shamim, Anwar
Source: Bioorganic and Medicinal Chemistry. Unidade: IQSC
Subjects: QUÍMICA MÉDICA, NEOPLASIAS, INIBIDORES DE ENZIMAS
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ABNT
CIANNI, Lorenzo et al. Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L. Bioorganic and Medicinal Chemistry, v. 29, p. 115827, 2021Tradução . . Disponível em: https://doi.org/10.1016/j.bmc.2020.115827. Acesso em: 03 dez. 2025.
APA
Cianni, L., Rocho, F. dos R., Bonatto, V., Martins, F. C. P., Lameira, J., Leitão, A., et al. (2021). Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L. Bioorganic and Medicinal Chemistry, 29, 115827. doi:10.1016/j.bmc.2020.115827
NLM
Cianni L, Rocho F dos R, Bonatto V, Martins FCP, Lameira J, Leitão A, Montanari CA, Shamim A. Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L [Internet]. Bioorganic and Medicinal Chemistry. 2021 ; 29 115827.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmc.2020.115827
Vancouver
Cianni L, Rocho F dos R, Bonatto V, Martins FCP, Lameira J, Leitão A, Montanari CA, Shamim A. Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L [Internet]. Bioorganic and Medicinal Chemistry. 2021 ; 29 115827.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmc.2020.115827
Artigo de periodico
The Effect of Dipeptidyl Nitrile Derivatives on Pancreatic Ductal Adenocarcinoma Cells In Vitro (2021)
Botelho, Sabrina Mendes ; Rocho, Fernanda dos Reis ; Cianni, Lorenzo ; Montanari, Carlos Alberto ; Leitão, Andrei
Source: Current Chemical Biology. Unidade: IQSC
Subjects: CÉLULAS, ANTINEOPLÁSICOS, TERAPIA COMBINADA
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ABNT
BOTELHO, Sabrina Mendes et al. The Effect of Dipeptidyl Nitrile Derivatives on Pancreatic Ductal Adenocarcinoma Cells In Vitro. Current Chemical Biology, v. 15, n. 4, p. 278 - 286, 2021Tradução . . Disponível em: https://doi.org/10.2174/2212796815666211214111243. Acesso em: 03 dez. 2025.
APA
Botelho, S. M., Rocho, F. dos R., Cianni, L., Montanari, C. A., & Leitão, A. (2021). The Effect of Dipeptidyl Nitrile Derivatives on Pancreatic Ductal Adenocarcinoma Cells In Vitro. Current Chemical Biology, 15( 4), 278 - 286. doi:10.2174/2212796815666211214111243
NLM
Botelho SM, Rocho F dos R, Cianni L, Montanari CA, Leitão A. The Effect of Dipeptidyl Nitrile Derivatives on Pancreatic Ductal Adenocarcinoma Cells In Vitro [Internet]. Current Chemical Biology. 2021 ;15( 4): 278 - 286.[citado 2025 dez. 03 ] Available from: https://doi.org/10.2174/2212796815666211214111243
Vancouver
Botelho SM, Rocho F dos R, Cianni L, Montanari CA, Leitão A. The Effect of Dipeptidyl Nitrile Derivatives on Pancreatic Ductal Adenocarcinoma Cells In Vitro [Internet]. Current Chemical Biology. 2021 ;15( 4): 278 - 286.[citado 2025 dez. 03 ] Available from: https://doi.org/10.2174/2212796815666211214111243
Artigo de periodico
Predicting the Relative Binding Affinity for Reversible Covalent Inhibitors by Free Energy Perturbation Calculations (2021)
Bonatto, Vinícius ; Shamim, Anwar ; Rocho, Fernanda dos Reis ; Leitão, Andrei ; Luque, F. Javier; Montanari, Carlos Alberto
Source: Journal of Chemical Information and Modeling. Unidade: IQSC
Subjects: MEDICAMENTO, ENZIMAS
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ABNT
BONATTO, Vinícius et al. Predicting the Relative Binding Affinity for Reversible Covalent Inhibitors by Free Energy Perturbation Calculations. Journal of Chemical Information and Modeling, v. 61, p. 4733−4744, 2021Tradução . . Disponível em: https://doi.org/10.1021/acs.jcim.1c00515. Acesso em: 03 dez. 2025.
APA
Bonatto, V., Shamim, A., Rocho, F. dos R., Leitão, A., Luque, F. J., & Montanari, C. A. (2021). Predicting the Relative Binding Affinity for Reversible Covalent Inhibitors by Free Energy Perturbation Calculations. Journal of Chemical Information and Modeling, 61, 4733−4744. doi:10.1021/acs.jcim.1c00515
NLM
Bonatto V, Shamim A, Rocho F dos R, Leitão A, Luque FJ, Montanari CA. Predicting the Relative Binding Affinity for Reversible Covalent Inhibitors by Free Energy Perturbation Calculations [Internet]. Journal of Chemical Information and Modeling. 2021 ; 61 4733−4744.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1021/acs.jcim.1c00515
Vancouver
Bonatto V, Shamim A, Rocho F dos R, Leitão A, Luque FJ, Montanari CA. Predicting the Relative Binding Affinity for Reversible Covalent Inhibitors by Free Energy Perturbation Calculations [Internet]. Journal of Chemical Information and Modeling. 2021 ; 61 4733−4744.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1021/acs.jcim.1c00515
Artigo de periodico
Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB (2020)
Matos, Thiago Kelvin Brito ; Batista, Pedro Henrique Jatai ; Rocho, Fernanda dos Reis ; Vita, Daniela de ; Pearce, Nicholas; Kellam, Barrie ; Montanari, Carlos Alberto ; Leitão, Andrei
Source: Bioorganic & Medicinal Chemistry Letters. Unidade: IQSC
Subjects: QUÍMICA ORGÂNICA, MEDICAMENTO, INIBIDORES DE ENZIMAS
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ABNT
MATOS, Thiago Kelvin Brito et al. Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB. Bioorganic & Medicinal Chemistry Letters, v. 30, n. 18, p. 127439, 2020Tradução . . Disponível em: https://doi.org/10.1016/j.bmcl.2020.127439. Acesso em: 03 dez. 2025.
APA
Matos, T. K. B., Batista, P. H. J., Rocho, F. dos R., Vita, D. de, Pearce, N., Kellam, B., et al. (2020). Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB. Bioorganic & Medicinal Chemistry Letters, 30( 18), 127439. doi:10.1016/j.bmcl.2020.127439
NLM
Matos TKB, Batista PHJ, Rocho F dos R, Vita D de, Pearce N, Kellam B, Montanari CA, Leitão A. Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB [Internet]. Bioorganic & Medicinal Chemistry Letters. 2020 ; 30( 18): 127439.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmcl.2020.127439
Vancouver
Matos TKB, Batista PHJ, Rocho F dos R, Vita D de, Pearce N, Kellam B, Montanari CA, Leitão A. Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB [Internet]. Bioorganic & Medicinal Chemistry Letters. 2020 ; 30( 18): 127439.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmcl.2020.127439
Artigo de periodico
Mapping the S1 and S1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents (2020)
Cianni, Lorenzo ; Lemke, Carina; Gilberg, Erik; Feldmann, Christian; Rosini, Fabiana; Rocho, Fernanda dos Reis ; Ribeiro, Jean Francisco Rosa; Tezuka, Daiane Yukie; Lopes, Carla Duque ; Albuquerque, Sérgio de ; Bajorath, Jürgen; Laufer, Stefan; Leitão, Andrei ; Gütschow Michaell; Montanari, Carlos Alberto
Source: PLoS Neglected Tropical Diseases. Unidades: IQSC, FCFRP, FMRP
Assunto: QUÍMICA MÉDICA
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ABNT
CIANNI, Lorenzo et al. Mapping the S1 and S1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents. PLoS Neglected Tropical Diseases, v. 14, n. 3, p. 1-36, 2020Tradução . . Disponível em: https://doi.org/10.1371/journal.pntd.0007755. Acesso em: 03 dez. 2025.
APA
Cianni, L., Lemke, C., Gilberg, E., Feldmann, C., Rosini, F., Rocho, F. dos R., et al. (2020). Mapping the S1 and S1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents. PLoS Neglected Tropical Diseases, 14( 3), 1-36. doi:10.1371/journal.pntd.0007755
NLM
Cianni L, Lemke C, Gilberg E, Feldmann C, Rosini F, Rocho F dos R, Ribeiro JFR, Tezuka DY, Lopes CD, Albuquerque S de, Bajorath J, Laufer S, Leitão A, Gütschow Michaell, Montanari CA. Mapping the S1 and S1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents [Internet]. PLoS Neglected Tropical Diseases. 2020 ; 14( 3): 1-36.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1371/journal.pntd.0007755
Vancouver
Cianni L, Lemke C, Gilberg E, Feldmann C, Rosini F, Rocho F dos R, Ribeiro JFR, Tezuka DY, Lopes CD, Albuquerque S de, Bajorath J, Laufer S, Leitão A, Gütschow Michaell, Montanari CA. Mapping the S1 and S1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents [Internet]. PLoS Neglected Tropical Diseases. 2020 ; 14( 3): 1-36.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1371/journal.pntd.0007755
Artigo de periodico
Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor (2020)
Ribeiro, Jean Francisco Rosa ; Cianni, Lorenzo ; Li, Chan; Warwick, Thomas G.; Vita, Daniela de ; Rosini, Fabiana; Rocho, Fernanda dos Reis ; Martins, Felipe Cardoso Prado ; Kenny, Peter W; Lameira, Jerônimo ; Leitão, Andrei ; Emsley, Jonas ; Montanari, Carlos Alberto
Source: Bioorganic and Medicinal Chemistry. Unidade: IQSC
Subjects: LEISHMANIA MEXICANA, MEDICAMENTO
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
ABNT
RIBEIRO, Jean Francisco Rosa et al. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor. Bioorganic and Medicinal Chemistry, v. 22, n. 22, p. 115743, 2020Tradução . . Disponível em: https://doi.org/10.1016/j.bmc.2020.115743. Acesso em: 03 dez. 2025.
APA
Ribeiro, J. F. R., Cianni, L., Li, C., Warwick, T. G., Vita, D. de, Rosini, F., et al. (2020). Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor. Bioorganic and Medicinal Chemistry, 22( 22), 115743. doi:10.1016/j.bmc.2020.115743
NLM
Ribeiro JFR, Cianni L, Li C, Warwick TG, Vita D de, Rosini F, Rocho F dos R, Martins FCP, Kenny PW, Lameira J, Leitão A, Emsley J, Montanari CA. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor [Internet]. Bioorganic and Medicinal Chemistry. 2020 ; 22( 22): 115743.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmc.2020.115743
Vancouver
Ribeiro JFR, Cianni L, Li C, Warwick TG, Vita D de, Rosini F, Rocho F dos R, Martins FCP, Kenny PW, Lameira J, Leitão A, Emsley J, Montanari CA. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor [Internet]. Bioorganic and Medicinal Chemistry. 2020 ; 22( 22): 115743.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmc.2020.115743
Artigo de periodico
Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases (2020)
Cianni, Lorenzo ; Rocho, Fernanda dos Reis ; Rosini, Fabiana; Bonatto, Vinícius ; Ribeiro, Jean Francisco Rosa ; Lameira, Jerônimo ; Leitão, Andrei ; Shamim, Anwar ; Montanari, Carlos Alberto
Source: Bioorganic Chemistry. Unidade: IQSC
Subjects: FÁRMACOS, BIOMARCADORES, PROTEÍNAS
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
ABNT
CIANNI, Lorenzo et al. Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases. Bioorganic Chemistry, v. 101, 2020Tradução . . Disponível em: https://doi.org/10.1016/j.bioorg.2020.104039. Acesso em: 03 dez. 2025.
APA
Cianni, L., Rocho, F. dos R., Rosini, F., Bonatto, V., Ribeiro, J. F. R., Lameira, J., et al. (2020). Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases. Bioorganic Chemistry, 101. doi:10.1016/j.bioorg.2020.104039
NLM
Cianni L, Rocho F dos R, Rosini F, Bonatto V, Ribeiro JFR, Lameira J, Leitão A, Shamim A, Montanari CA. Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases [Internet]. Bioorganic Chemistry. 2020 ; 101[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bioorg.2020.104039
Vancouver
Cianni L, Rocho F dos R, Rosini F, Bonatto V, Ribeiro JFR, Lameira J, Leitão A, Shamim A, Montanari CA. Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases [Internet]. Bioorganic Chemistry. 2020 ; 101[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bioorg.2020.104039
Artigo de periodico
N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization (2020)
Lemke, Carina; Cianni, Lorenzo ; Feldmann, Christian; Gilberg, Erik; Yin, Jiafei; Rocho, Fernanda dos Reis ; Vita, Daniela de ; Bartz, Ulrike; Bajorath, Jürgen ; Montanari, Carlos Alberto ; Gütschow, Michael
Source: Bioorganic & Medicinal Chemistry Letters. Unidade: IQSC
Subjects: BIOQUÍMICA, PEPTÍDEOS, NITRILAS
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
ABNT
LEMKE, Carina et al. N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization. Bioorganic & Medicinal Chemistry Letters, v. 30, 2020Tradução . . Disponível em: https://doi.org/10.1016/j.bmcl.2020.127420. Acesso em: 03 dez. 2025.
APA
Lemke, C., Cianni, L., Feldmann, C., Gilberg, E., Yin, J., Rocho, F. dos R., et al. (2020). N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization. Bioorganic & Medicinal Chemistry Letters, 30. doi:10.1016/j.bmcl.2020.127420
NLM
Lemke C, Cianni L, Feldmann C, Gilberg E, Yin J, Rocho F dos R, Vita D de, Bartz U, Bajorath J, Montanari CA, Gütschow M. N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization [Internet]. Bioorganic & Medicinal Chemistry Letters. 2020 ; 30[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmcl.2020.127420
Vancouver
Lemke C, Cianni L, Feldmann C, Gilberg E, Yin J, Rocho F dos R, Vita D de, Bartz U, Bajorath J, Montanari CA, Gütschow M. N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization [Internet]. Bioorganic & Medicinal Chemistry Letters. 2020 ; 30[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmcl.2020.127420
Artigo de periodico
Organometallic Gold(III) complex [Au(Hdamp)(L14)]+ (L1 = SNSDonating Thiosemicarbazone) as a candidate to new formulations against Chagas disease (2019)
Lopes, Carla Duque ; Possato, Bruna ; Gaspari, Ana Paula Segantin ; Oliveira, Ronaldo Junio ; Abram, Ulrich ; Almeida, José P. A; Rocho, Fernanda dos Reis ; Leitão, Andrei ; Montanari, Carlos Alberto ; Maia, Pedro Ivo da Silva ; Silva, João Santana da ; Albuquerque, Sérgio de ; Carneiro, Zumira Aparecida
Source: ACS Infectious Diseases. Unidades: IQSC, FMRP, FCFRP
Subjects: BIOQUÍMICA, DOENÇA DE CHAGAS
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ABNT
LOPES, Carla Duque et al. Organometallic Gold(III) complex [Au(Hdamp)(L14)]+ (L1 = SNSDonating Thiosemicarbazone) as a candidate to new formulations against Chagas disease. ACS Infectious Diseases, v. 5, n. 10, p. 1698-1707, 2019Tradução . . Disponível em: https://doi.org/10.1021/acsinfecdis.8b00284. Acesso em: 03 dez. 2025.
APA
Lopes, C. D., Possato, B., Gaspari, A. P. S., Oliveira, R. J., Abram, U., Almeida, J. P. A., et al. (2019). Organometallic Gold(III) complex [Au(Hdamp)(L14)]+ (L1 = SNSDonating Thiosemicarbazone) as a candidate to new formulations against Chagas disease. ACS Infectious Diseases, 5( 10), 1698-1707. doi:10.1021/acsinfecdis.8b00284
NLM
Lopes CD, Possato B, Gaspari APS, Oliveira RJ, Abram U, Almeida JPA, Rocho F dos R, Leitão A, Montanari CA, Maia PI da S, Silva JS da, Albuquerque S de, Carneiro ZA. Organometallic Gold(III) complex [Au(Hdamp)(L14)]+ (L1 = SNSDonating Thiosemicarbazone) as a candidate to new formulations against Chagas disease [Internet]. ACS Infectious Diseases. 2019 ; 5( 10): 1698-1707.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1021/acsinfecdis.8b00284
Vancouver
Lopes CD, Possato B, Gaspari APS, Oliveira RJ, Abram U, Almeida JPA, Rocho F dos R, Leitão A, Montanari CA, Maia PI da S, Silva JS da, Albuquerque S de, Carneiro ZA. Organometallic Gold(III) complex [Au(Hdamp)(L14)]+ (L1 = SNSDonating Thiosemicarbazone) as a candidate to new formulations against Chagas disease [Internet]. ACS Infectious Diseases. 2019 ; 5( 10): 1698-1707.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1021/acsinfecdis.8b00284
Artigo de periodico
Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells (2019)
Quilles Junior, José Carlos ; Rocho, Fernanda dos Reis ; Montanari, Carlos Alberto ; Leitão, Andrei ; Mignone, Viviane W.; Arruda, Maria Augusta; Turyanska, Lyudmila ; Bradshaw, Tracey D.
Source: RSC Advances. Unidade: IQSC
Subjects: QUÍMICA MÉDICA, NEOPLASIAS, PÂNCREAS
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ABNT
QUILLES JUNIOR, José Carlos et al. Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells. RSC Advances, v. 9, n. 45, p. 36699-36706, 2019Tradução . . Disponível em: https://doi.org/10.1039/c9ra07161j. Acesso em: 03 dez. 2025.
APA
Quilles Junior, J. C., Rocho, F. dos R., Montanari, C. A., Leitão, A., Mignone, V. W., Arruda, M. A., et al. (2019). Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells. RSC Advances, 9( 45), 36699-36706. doi:10.1039/c9ra07161j
NLM
Quilles Junior JC, Rocho F dos R, Montanari CA, Leitão A, Mignone VW, Arruda MA, Turyanska L, Bradshaw TD. Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells [Internet]. RSC Advances. 2019 ; 9( 45): 36699-36706.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1039/c9ra07161j
Vancouver
Quilles Junior JC, Rocho F dos R, Montanari CA, Leitão A, Mignone VW, Arruda MA, Turyanska L, Bradshaw TD. Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells [Internet]. RSC Advances. 2019 ; 9( 45): 36699-36706.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1039/c9ra07161j
Artigo de periodico
Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement (2019)
Gomes, Juliana C; Cianni, Lorenzo ; Ribeiro, Jean; Rocho, Fernanda dos Reis ; Silva, Samelyn da Costa Martins ; Batista, Pedro Henrique J; Moraes, Carolina Borsoi ; Franco, Caio Haddad ; Freitas Junior, Lúcio H G ; Kenny, Peter W; Leitão, Andrei ; Burtoloso, Antonio Carlos Bender ; Vita, Daniela de; Montanari, Carlos Alberto
Source: Bioorganic and Medicinal Chemistry. Unidades: IQSC, ICB
Assunto: QUÍMICA
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
ABNT
GOMES, Juliana C et al. Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement. Bioorganic and Medicinal Chemistry, v. 27, n. 22, p. x 115083, 2019Tradução . . Disponível em: https://doi.org/10.1016/j.bmc.2019.115083. Acesso em: 03 dez. 2025.
APA
Gomes, J. C., Cianni, L., Ribeiro, J., Rocho, F. dos R., Silva, S. da C. M., Batista, P. H. J., et al. (2019). Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement. Bioorganic and Medicinal Chemistry, 27( 22), x 115083. doi:10.1016/j.bmc.2019.115083
NLM
Gomes JC, Cianni L, Ribeiro J, Rocho F dos R, Silva S da CM, Batista PHJ, Moraes CB, Franco CH, Freitas Junior LHG, Kenny PW, Leitão A, Burtoloso ACB, Vita D de, Montanari CA. Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement [Internet]. Bioorganic and Medicinal Chemistry. 2019 ; 27( 22): x 115083.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmc.2019.115083
Vancouver
Gomes JC, Cianni L, Ribeiro J, Rocho F dos R, Silva S da CM, Batista PHJ, Moraes CB, Franco CH, Freitas Junior LHG, Kenny PW, Leitão A, Burtoloso ACB, Vita D de, Montanari CA. Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement [Internet]. Bioorganic and Medicinal Chemistry. 2019 ; 27( 22): x 115083.[citado 2025 dez. 03 ] Available from: https://doi.org/10.1016/j.bmc.2019.115083

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